• 1. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 2. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 3. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 4. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 5. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020

Comprehensive Overview of 3-Methyl-5-nitropyridin-4-amine (CAS No. 18227-67-3): Properties, Applications, and Market Insights

3-Methyl-5-nitropyridin-4-amine (CAS No. 18227-67-3) is a specialized nitropyridine derivative that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its unique molecular structure featuring a methyl group at the 3-position and a nitro group at the 5-position of the pyridine ring, serves as a versatile intermediate in organic synthesis. Researchers and industry professionals frequently search for terms like "3-Methyl-5-nitropyridin-4-amine synthesis", "CAS 18227-67-3 applications", and "nitropyridine derivatives in drug discovery", reflecting its growing relevance in modern chemistry.

The physicochemical properties of 3-Methyl-5-nitropyridin-4-amine make it particularly valuable in heterocyclic chemistry. With a molecular formula of C₆H₇N₃O₂ and a molecular weight of 153.14 g/mol, this yellow to light brown crystalline powder exhibits moderate solubility in polar organic solvents. Its melting point typically ranges between 145-150°C, and it demonstrates stability under standard laboratory conditions. Recent studies have explored its potential as a precursor for biologically active compounds, aligning with current trends in fragment-based drug design and medicinal chemistry optimization.

In pharmaceutical applications, 3-Methyl-5-nitropyridin-4-amine has shown promise as a building block for various therapeutic agents. The compound's structural features allow for diverse chemical modifications, making it valuable in developing kinase inhibitors and antimicrobial agents. Recent patent literature reveals its incorporation into novel compounds targeting inflammatory pathways and metabolic disorders, addressing pressing healthcare challenges. The surge in searches for "nitropyridine-based pharmaceuticals" and "small molecule drug development" underscores the industry's interest in such specialized intermediates.

The agrochemical sector has also recognized the potential of 3-Methyl-5-nitropyridin-4-amine, particularly in developing crop protection agents. Its nitro and amino functional groups provide sites for creating derivatives with herbicidal or fungicidal activity. This application aligns with the growing demand for sustainable agriculture solutions and precision farming technologies, topics frequently searched in conjunction with "novel agrochemical intermediates". Researchers are particularly interested in how such compounds can contribute to environmentally friendly pest management systems.

From a synthetic chemistry perspective, 3-Methyl-5-nitropyridin-4-amine offers multiple advantages. Its preparation typically involves nitration reactions of appropriately substituted pyridine precursors, followed by selective reduction. The compound's reactivity allows for various transformations, including cross-coupling reactions and nucleophilic substitutions, making it valuable for constructing complex molecular architectures. Laboratory professionals often search for "optimized synthesis of 3-Methyl-5-nitropyridin-4-amine" and "purification methods for nitropyridine derivatives", indicating the practical challenges in working with this compound.

The market for 3-Methyl-5-nitropyridin-4-amine reflects broader trends in fine chemicals and specialty intermediates. With increasing demand from both pharmaceutical and agrochemical sectors, suppliers have developed improved production processes to ensure consistent quality and scalability. Current market analyses show growing interest in "CAS 18227-67-3 suppliers" and "custom synthesis of nitropyridine compounds", particularly from regions with strong research and manufacturing capabilities in life sciences.

Quality control and analytical characterization represent critical aspects of working with 3-Methyl-5-nitropyridin-4-amine. Standard analytical techniques include HPLC for purity assessment, mass spectrometry for structural confirmation, and X-ray crystallography for definitive characterization. The compound's stability profile requires proper storage conditions, typically recommending protection from light and moisture. These technical considerations frequently appear in searches for "handling guidelines for nitropyridine derivatives" and "analytical methods for amine-containing heterocycles".

Recent scientific literature highlights innovative applications of 3-Methyl-5-nitropyridin-4-amine in materials science. Researchers have explored its potential as a precursor for functionalized polymers and coordination complexes, particularly in developing advanced materials with tailored electronic properties. This expansion into materials chemistry aligns with searches for "nitrogen-containing heterocycles in material design" and "pyridine derivatives for electronic applications", reflecting interdisciplinary interest in such compounds.

Environmental and regulatory considerations surrounding 3-Methyl-5-nitropyridin-4-amine remain important discussion points. While not classified as hazardous under current regulations, proper laboratory practices should be followed when handling this compound. The scientific community continues to investigate its environmental fate and biodegradation pathways, responding to searches for "green chemistry approaches to nitropyridine synthesis" and "sustainability in heterocyclic chemistry".

Future research directions for 3-Methyl-5-nitropyridin-4-amine may focus on expanding its utility in catalysis and asymmetric synthesis. The compound's structural features suggest potential as a ligand in transition metal catalysis or as a chiral auxiliary in stereoselective transformations. Such developments would address growing interest in "nitropyridine-based catalysts" and "heterocyclic scaffolds in asymmetric synthesis", positioning this compound at the forefront of modern synthetic methodology development.

• 1681-37-4(3-nitropyridin-4-amine)
• 31793-29-0(4-Amino-3,5-dinitropyridine)
• 5832-44-0(4-methyl-3-nitro-pyridine)
• 65169-36-0(3,4-Dimethyl-5-nitropyridine)
• 6960-20-9(3-Methyl-5-nitropyridine)
• 57927-98-7(4-Methyl-3,5-dinitropyridine)
• 4318-68-7(5-Nitropyridine-3,4-diamine (>90%))
• 14916-69-9(Pyridine, 3,4-dinitro-)
• 7598-26-7(5-Methyl-3-nitropyridin-2-amine)
• 131941-33-8(3-Isopropyl-5-nitropyridine)