Cas no 1810-13-5 (3,3,4,4-Tetrafluoropyrrolidine Hydrochloride)

3,3,4,4-Tetrafluoropyrrolidine Hydrochloride is a fluorinated pyrrolidine derivative commonly employed as a versatile building block in organic synthesis and pharmaceutical research. The incorporation of fluorine atoms enhances its reactivity and stability, making it valuable for the development of bioactive compounds, particularly in medicinal chemistry. Its hydrochloride salt form improves solubility and handling, facilitating its use in nucleophilic substitution and other reactions. This compound is particularly useful in the synthesis of fluorinated heterocycles, which are increasingly important in drug discovery due to their improved metabolic stability and binding affinity. Its well-defined structure and high purity ensure consistent performance in synthetic applications.
3,3,4,4-Tetrafluoropyrrolidine Hydrochloride structure
1810-13-5 structure
Product Name:3,3,4,4-Tetrafluoropyrrolidine Hydrochloride
CAS No:1810-13-5
MF:C4H6ClF4N
MW:179.5437541008
MDL:MFCD06200835
CID:118102
PubChem ID:22645920
Update Time:2025-06-08

3,3,4,4-Tetrafluoropyrrolidine Hydrochloride Chemical and Physical Properties

Names and Identifiers

    • 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride
    • Pyrrolidine,3,3,4,4-tetrafluoro-, hydrochloride (1:1)
    • 3,3,4,4,-tetrafluoropyrrolidine-HCl
    • 3,3,4,4-tetrafluoro-pyrrolidine hydrochloride
    • Pyrrolidine,3,3,4,4-tetrafluoro-,hydrochloride
    • C4H6ClF4N
    • 3,3,4,4-Tetrafluoropyrrolidine HCl
    • Pyrrolidine, 3,3,4,4-tetrafluoro-, hydrochloride
    • 3,4-Tetrafluoropyrrolidine HCl
    • KPTMFLKIYHWQPB-UHFFFAOYSA-N
    • VP60223
    • SB20485
    • AB1010894
    • ST2404563
    • W3987
    • 3.3.4.4-Tetrafluo
    • FT-0758230
    • Pyrrolidine, 3,3,4,4-tetrafluoro-, hydrochloride (1:1)
    • EN300-250731
    • 3,4-Tetrafluoropyrrolidine hydrochloride
    • SCHEMBL519207
    • PYRROLIDINE,3,3,4,4-TETRAFLUORO-
    • AKOS015849211
    • NS00018829
    • 3,3,4,4-tetrafluoropyrrolidine;hydrochloride
    • T2342
    • MFCD06200835
    • AS-34641
    • SY039508
    • Z2284386313
    • 1841-00-5
    • A881032
    • 3,3,4,4-Tetrafluoropyrrolidine hydrochloride, AldrichCPR
    • 1810-13-5
    • 3.3.4.4-Tetrafluoro-pyrrolidine Hydrochloride
    • DTXSID10880173
    • AMY14686
    • CS-0051639
    • J-011554
    • FT-0600122
    • DB-006260
    • DA-17816
    • 3,3,4,4-Tetrafluoropyrrolidinehydrochloride
    • MDL： MFCD06200835
    • Inchi： 1S/C4H5F4N.ClH/c5-3(6)1-9-2-4(3,7)8;/h9H,1-2H2;1H
    • InChI Key： KPTMFLKIYHWQPB-UHFFFAOYSA-N
    • SMILES： Cl.FC1(CNCC1(F)F)F

Computed Properties

  • Exact Mass: 179.01200
  • Monoisotopic Mass: 179.0124895g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 0
  • Complexity: 108
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 2
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 12
  • Surface Charge: 0
  • XLogP3: 3.8

Experimental Properties

  • PSA: 12.03000
  • LogP: 1.99100

3,3,4,4-Tetrafluoropyrrolidine Hydrochloride Security Information

3,3,4,4-Tetrafluoropyrrolidine Hydrochloride Customs Data

  • HS CODE：2933990090
  • Customs Data：

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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3,3,4,4-Tetrafluoropyrrolidine Hydrochloride Suppliers

Amadis Chemical Company Limited
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(CAS:1810-13-5)3,3,4,4-Tetrafluoropyrrolidine Hydrochloride
Order Number:A881032
Stock Status:in Stock
Quantity:25g/10g/5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 11:02
Price ($):1709.0/684.0/372.0

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Additional information on 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride

3,3,4,4-Tetrafluoropyrrolidine Hydrochloride (CAS No. 1810-13-5): An Overview of Its Properties and Applications

3,3,4,4-Tetrafluoropyrrolidine Hydrochloride (CAS No. 1810-13-5) is a highly versatile compound with a unique chemical structure that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its four fluorine atoms and a pyrrolidine ring, which confer it with distinct physicochemical properties and biological activities. In this article, we will delve into the key aspects of 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride, including its synthesis, properties, and potential applications in drug development.

The synthesis of 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride typically involves several steps that ensure the introduction of fluorine atoms into the pyrrolidine ring. One common approach is the fluorination of a pyrrolidine derivative using selective fluorinating agents such as Selectfluor or N-fluorobenzenesulfonimide (NFSI). These methods have been optimized to achieve high yields and regioselectivity, making the synthesis process efficient and scalable for industrial applications.

The physicochemical properties of 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride are of particular interest due to the presence of fluorine atoms. Fluorine is known for its strong electron-withdrawing effect and ability to modulate the electronic properties of organic molecules. This results in enhanced lipophilicity and metabolic stability, which are crucial for drug candidates. Additionally, the hydrochloride salt form improves solubility in aqueous media, facilitating its use in various biological assays and formulations.

In terms of biological activity, 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride has shown promise in several areas of medicinal chemistry. Recent studies have demonstrated its potential as a scaffold for the development of novel therapeutic agents. For instance, derivatives of this compound have been explored as inhibitors of specific enzymes involved in various disease pathways. One notable example is its use as a potent inhibitor of histone deacetylases (HDACs), which are implicated in cancer and neurodegenerative disorders.

The pharmacological profile of 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride has been extensively studied through in vitro and in vivo experiments. In cell-based assays, it has exhibited significant antiproliferative effects against various cancer cell lines. Furthermore, preclinical studies have shown that it can effectively cross the blood-brain barrier (BBB), making it a promising candidate for treating central nervous system (CNS) disorders.

The safety and toxicity profile of 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride have also been evaluated. Animal studies have indicated that it is well-tolerated at therapeutic doses with minimal adverse effects. However, further research is needed to fully understand its long-term safety and potential side effects in humans.

In conclusion, 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride (CAS No. 1810-13-5) represents a valuable chemical entity with a wide range of potential applications in drug discovery and development. Its unique chemical structure and favorable physicochemical properties make it an attractive scaffold for the design of novel therapeutic agents. Ongoing research continues to uncover new avenues for its use in treating various diseases, highlighting its significance in the field of medicinal chemistry.

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Amadis Chemical Company Limited
(CAS:1810-13-5)3,3,4,4-Tetrafluoropyrrolidine Hydrochloride
A881032
Purity:99%/99%/99%
Quantity:25g/10g/5g
Price ($):1709.0/684.0/372.0
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