• 1. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 2. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 3. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 4. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 5. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Pyrrolidinecarboxamides
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Pyrrolidine carboxylic acids and derivatives Pyrrolidinecarboxamides

Comprehensive Overview of rac-(2R,3R)-1-tert-butyl-2-(1-methyl-1H-pyrazol-4-yl)-5-oxopyrrolidine-3-carboxamide, trans (CAS No. 1807884-98-5)

The compound rac-(2R,3R)-1-tert-butyl-2-(1-methyl-1H-pyrazol-4-yl)-5-oxopyrrolidine-3-carboxamide, trans (CAS No. 1807884-98-5) is a highly specialized chiral molecule with significant potential in pharmaceutical research and development. Its unique structural features, including a pyrrolidine core and a 1-methyl-1H-pyrazol-4-yl substituent, make it a valuable intermediate for drug discovery. The tert-butyl group enhances its stability, while the trans configuration ensures stereochemical precision, a critical factor in modern medicinal chemistry.

In recent years, the demand for chiral compounds like rac-(2R,3R)-1-tert-butyl-2-(1-methyl-1H-pyrazol-4-yl)-5-oxopyrrolidine-3-carboxamide, trans has surged due to their applications in asymmetric synthesis and targeted drug design. Researchers are particularly interested in its potential as a protease inhibitor or kinase modulator, given the growing focus on precision medicine. The compound's CAS No. 1807884-98-5 is frequently searched in academic databases, reflecting its relevance in cutting-edge therapeutic areas such as oncology and neurology.

One of the most compelling aspects of this compound is its role in addressing drug resistance, a hot topic in pharmaceutical science. By incorporating the 1-methyl-1H-pyrazol-4-yl moiety, scientists can explore novel mechanisms to overcome resistance pathways in diseases like cancer. Additionally, the pyrrolidine-3-carboxamide scaffold is known for its bioavailability, making it a preferred choice for oral drug formulations. These attributes align with the industry's shift toward small-molecule therapeutics with improved pharmacokinetic profiles.

From a synthetic perspective, the preparation of rac-(2R,3R)-1-tert-butyl-2-(1-methyl-1H-pyrazol-4-yl)-5-oxopyrrolidine-3-carboxamide, trans involves advanced techniques such as enantioselective catalysis and chiral resolution. These methods are critical for achieving the desired trans configuration, which directly impacts the compound's biological activity. The tert-butyl group also plays a strategic role in protecting reactive sites during multi-step syntheses, a common challenge in complex molecule construction.

In the context of AI-driven drug discovery, compounds like rac-(2R,3R)-1-tert-butyl-2-(1-methyl-1H-pyrazol-4-yl)-5-oxopyrrolidine-3-carboxamide, trans are increasingly analyzed using machine learning models to predict their binding affinities and toxicity profiles. This intersection of chemistry and technology is revolutionizing how researchers prioritize candidates for preclinical studies. The compound's CAS No. 1807884-98-5 often appears in datasets used to train these algorithms, underscoring its importance in computational chemistry.

Environmental and regulatory considerations are also shaping the discourse around such compounds. The pyrrolidine and pyrazole motifs are generally regarded as environmentally benign, aligning with the pharmaceutical industry's push toward green chemistry. This focus on sustainability is driving innovation in solvent-free synthesis and catalytic methods, further enhancing the appeal of rac-(2R,3R)-1-tert-butyl-2-(1-methyl-1H-pyrazol-4-yl)-5-oxopyrrolidine-3-carboxamide, trans as a model substrate.

In summary, rac-(2R,3R)-1-tert-butyl-2-(1-methyl-1H-pyrazol-4-yl)-5-oxopyrrolidine-3-carboxamide, trans (CAS No. 1807884-98-5) represents a convergence of structural ingenuity and therapeutic potential. Its applications span from drug resistance research to AI-aided molecular design, making it a cornerstone of modern pharmaceutical science. As the field evolves, this compound will likely remain at the forefront of discussions on innovation and efficiency in drug development.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)