Cas no 1806531-03-2 (2,5-Bis(trifluoromethyl)-3-(difluoromethyl)pyridine)
2,5-Bis(trifluoromethyl)-3-(difluoromethyl)pyridine is a fluorinated pyridine derivative characterized by its high electron-withdrawing properties due to the presence of multiple fluorine substituents. This compound is particularly valuable in pharmaceutical and agrochemical research, where its trifluoromethyl and difluoromethyl groups enhance metabolic stability and lipophilicity. Its structural features make it a versatile intermediate for synthesizing bioactive molecules, including potential enzyme inhibitors or receptor modulators. The strong inductive effects of the fluorine substituents also contribute to improved binding affinity in target interactions. Additionally, the compound's stability under various reaction conditions allows for further functionalization, making it a useful building block in medicinal chemistry and material science applications.
1806531-03-2 structure
Product Name:2,5-Bis(trifluoromethyl)-3-(difluoromethyl)pyridine
CAS No:1806531-03-2
MF:C8H3F8N
MW:265.103349924088
CID:4801967
Update Time:2025-10-13
2,5-Bis(trifluoromethyl)-3-(difluoromethyl)pyridine Chemical and Physical Properties
Names and Identifiers
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- 2,5-Bis(trifluoromethyl)-3-(difluoromethyl)pyridine
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- Inchi: 1S/C8H3F8N/c9-6(10)4-1-3(7(11,12)13)2-17-5(4)8(14,15)16/h1-2,6H
- InChI Key: HEFYYIYXOVEGSW-UHFFFAOYSA-N
- SMILES: FC(C1=CC(C(F)(F)F)=CN=C1C(F)(F)F)F
Computed Properties
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 9
- Heavy Atom Count: 17
- Rotatable Bond Count: 1
- Complexity: 257
- XLogP3: 3.3
- Topological Polar Surface Area: 12.9
2,5-Bis(trifluoromethyl)-3-(difluoromethyl)pyridine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Alichem | A029002444-250mg |
2,5-Bis(trifluoromethyl)-3-(difluoromethyl)pyridine |
1806531-03-2 | 95% | 250mg |
$1,038.80 | 2022-03-31 | |
| Alichem | A029002444-500mg |
2,5-Bis(trifluoromethyl)-3-(difluoromethyl)pyridine |
1806531-03-2 | 95% | 500mg |
$1,685.00 | 2022-03-31 | |
| Alichem | A029002444-1g |
2,5-Bis(trifluoromethyl)-3-(difluoromethyl)pyridine |
1806531-03-2 | 95% | 1g |
$2,923.95 | 2022-03-31 |
2,5-Bis(trifluoromethyl)-3-(difluoromethyl)pyridine Related Literature
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Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
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Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
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Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
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Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
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Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
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