Cas no 1806288-80-1 (2,5-Dichloro-4-(methylsulfonyl)pyrimidine)

2,5-Dichloro-4-(methylsulfonyl)pyrimidine is a versatile pyrimidine derivative characterized by its reactive dichloro and methylsulfonyl functional groups. This compound serves as a valuable intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty chemicals. The presence of electron-withdrawing substituents enhances its reactivity in nucleophilic substitution reactions, allowing for selective functionalization. Its stability under standard storage conditions and high purity make it suitable for precision applications in research and industrial processes. The compound’s structural features facilitate its use in constructing complex heterocyclic frameworks, underscoring its utility in medicinal chemistry and material science.
2,5-Dichloro-4-(methylsulfonyl)pyrimidine structure
1806288-80-1 structure
Product Name:2,5-Dichloro-4-(methylsulfonyl)pyrimidine
CAS No:1806288-80-1
MF:C5H4Cl2N2O2S
MW:227.068457603455
CID:4826520
Update Time:2025-05-20

2,5-Dichloro-4-(methylsulfonyl)pyrimidine Chemical and Physical Properties

Names and Identifiers

    • 2,5-Dichloro-4-(methylsulfonyl)pyrimidine
    • Inchi： 1S/C5H4Cl2N2O2S/c1-12(10,11)4-3(6)2-8-5(7)9-4/h2H,1H3
    • InChI Key： XVMTUGKYQDPRBI-UHFFFAOYSA-N
    • SMILES： ClC1=CN=C(N=C1S(C)(=O)=O)Cl

Computed Properties

  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 1
  • Complexity: 251
  • XLogP3: 1.4
  • Topological Polar Surface Area: 68.3

2,5-Dichloro-4-(methylsulfonyl)pyrimidine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Alichem
A039002276-250mg
2,5-Dichloro-4-(methylsulfonyl)pyrimidine
 1806288-80-1 98%
250mg
 $890.43 2022-03-31
Alichem
A039002276-500mg
2,5-Dichloro-4-(methylsulfonyl)pyrimidine
 1806288-80-1 98%
500mg
 $1,271.49 2022-03-31
Alichem
A039002276-1g
2,5-Dichloro-4-(methylsulfonyl)pyrimidine
 1806288-80-1 98%
1g
 $1,983.77 2022-03-31

2,5-Dichloro-4-(methylsulfonyl)pyrimidine Related Literature

Additional information on 2,5-Dichloro-4-(methylsulfonyl)pyrimidine

Comprehensive Overview of 2,5-Dichloro-4-(methylsulfonyl)pyrimidine (CAS No. 1806288-80-1)

2,5-Dichloro-4-(methylsulfonyl)pyrimidine (CAS No. 1806288-80-1) is a high-value pyrimidine derivative widely utilized in pharmaceutical and agrochemical research. This compound features a unique methylsulfonyl group, enhancing its reactivity and making it a critical intermediate in synthesizing advanced molecules. Its dichloropyrimidine backbone is particularly sought after for designing kinase inhibitors and antiviral agents, aligning with current trends in drug discovery targeting RNA-dependent RNA polymerase (RdRp) and tyrosine kinase pathways.

In recent years, the demand for sulfonyl-containing heterocycles like 2,5-Dichloro-4-(methylsulfonyl)pyrimidine has surged due to their role in developing small-molecule therapeutics. Researchers frequently search for "pyrimidine-based drug intermediates" or "methylsulfonyl pyrimidine applications," reflecting its relevance in cancer research and infectious disease studies. The compound’s electron-withdrawing properties also make it ideal for cross-coupling reactions, a hotspot in green chemistry and catalysis.

From a synthetic perspective, CAS 1806288-80-1 is pivotal for constructing N-heterocyclic scaffolds, a topic dominating medicinal chemistry forums. Its compatibility with Pd-catalyzed reactions and Suzuki-Miyaura couplings addresses frequent queries like "how to modify pyrimidine rings" or "best practices for sulfonyl group incorporation." These attributes position it as a versatile building block for high-throughput screening libraries.

Environmental and regulatory considerations further highlight the compound’s appeal. Unlike traditional halogenated reagents, 2,5-Dichloro-4-(methylsulfonyl)pyrimidine exhibits improved biodegradability profiles, resonating with sustainable chemistry initiatives. Searches for "eco-friendly sulfonyl precursors" or "low-toxicity pyrimidine synthesis" underscore its alignment with ESG (Environmental, Social, and Governance) goals in chemical manufacturing.

Analytical characterization of 1806288-80-1 typically involves HPLC purity assays and NMR spectroscopy, topics frequently explored in quality control discussions. The compound’s crystalline structure and solubility data are also critical for formulators, addressing common questions like "how to optimize pyrimidine solubility" or "stable sulfone derivatives for API development."

In summary, 2,5-Dichloro-4-(methylsulfonyl)pyrimidine (CAS No. 1806288-80-1) bridges multiple scientific disciplines, from drug design to material science. Its structural versatility and reaction efficiency ensure its prominence in peer-reviewed literature and industrial applications, making it a staple for researchers navigating next-generation therapeutic development.

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