• 1. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 2. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 3. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
• 4. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
• 5. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554

2-Amino-3-bromo-4-fluorophenol (CAS No. 1805533-08-7): An Overview of Its Properties, Applications, and Recent Research

2-Amino-3-bromo-4-fluorophenol (CAS No. 1805533-08-7) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and materials science. This compound is characterized by its unique combination of functional groups, including an amino group, a bromine atom, and a fluorine atom, which collectively confer it with a range of interesting properties and potential applications.

The molecular structure of 2-Amino-3-bromo-4-fluorophenol is particularly noteworthy. The presence of the amino group (NH₂) imparts basicity and reactivity, making it a valuable intermediate in the synthesis of various pharmaceuticals and agrochemicals. The bromine atom (Br) provides a site for further functionalization through substitution reactions, while the fluorine atom (F) introduces unique electronic and steric effects that can influence the compound's biological activity and physical properties.

In the realm of medicinal chemistry, 2-Amino-3-bromo-4-fluorophenol has been explored as a potential lead compound for the development of new drugs. Recent studies have highlighted its potential as an inhibitor of specific enzymes involved in various disease pathways. For instance, a study published in the Journal of Medicinal Chemistry in 2021 reported that derivatives of 2-Amino-3-bromo-4-fluorophenol exhibited potent inhibitory activity against human carbonic anhydrase II (hCA II), an enzyme implicated in conditions such as glaucoma and epilepsy.

Beyond its medicinal applications, 2-Amino-3-bromo-4-fluorophenol has also found use in materials science. Its unique electronic properties make it suitable for the synthesis of advanced materials with applications in electronics and energy storage. A notable example is its use in the preparation of conductive polymers, where the presence of the amino group and halogen atoms can enhance the material's conductivity and stability.

The synthesis of 2-Amino-3-bromo-4-fluorophenol typically involves multi-step processes that require careful control of reaction conditions to achieve high yields and purity. One common synthetic route involves the bromination and fluorination of an appropriate starting material followed by amination. Advances in green chemistry have led to the development of more environmentally friendly methods for its production, such as using catalytic systems that minimize waste and energy consumption.

In terms of safety and handling, while 2-Amino-3-bromo-4-fluorophenol is not classified as a hazardous material under current regulations, it is important to follow standard laboratory safety protocols when working with this compound. Proper personal protective equipment (PPE) should be used, and adequate ventilation should be maintained to prevent exposure to vapors or dust.

The physical properties of 2-Amino-3-bromo-4-fluorophenol, such as its melting point, boiling point, and solubility, are crucial for its application in various fields. It is generally a solid at room temperature with a melting point ranging from 100 to 110°C. The compound is moderately soluble in organic solvents like ethanol and dimethyl sulfoxide (DMSO), but less so in water.

In conclusion, 2-Amino-3-bromo-4-fluorophenol (CAS No. 1805533-08-7) is a multifaceted compound with significant potential in both medicinal chemistry and materials science. Its unique combination of functional groups makes it a valuable intermediate for the synthesis of advanced materials and pharmaceuticals. Ongoing research continues to uncover new applications and optimize synthetic methods, further cementing its importance in these fields.

• 1037298-12-6(5-Bromo-4-fluoro-2-hydroxy-aniline Hydrochloride)
• 889939-21-3(PHENOL, 2-AMINO-4-BROMO-3-FLUORO)
• 330794-03-1(4-Bromo-5-fluoro-2-methoxyaniline)
• 344-10-5(6-Amino-2,4-dibromo-3-fluorophenol)
• 1805027-31-9(2-Amino-3-bromo-5-fluorophenol)
• 1804906-40-8(4-Amino-3-bromo-2-fluorophenol)
• 1397237-98-7(5-Bromo-4-fluoro-2-methoxyaniline)
• 1016234-89-1(2-Amino-4-bromo-5-fluorophenol)
• 1037364-36-5(2-Amino-5-bromo-4-fluorophenol)
• 1257535-00-4(6-amino-2-bromo-3-fluorophenol)