Cas no 1804848-55-2 (2-Bromo-4-methoxy-5-(trifluoromethoxy)aniline)
2-Bromo-4-methoxy-5-(trifluoromethoxy)aniline is a halogenated aniline derivative featuring bromo, methoxy, and trifluoromethoxy substituents on the aromatic ring. This compound is primarily utilized as a versatile intermediate in pharmaceutical and agrochemical synthesis, where its electron-withdrawing and electron-donating groups enable selective functionalization. The presence of both bromine and trifluoromethoxy groups enhances its reactivity in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig couplings, facilitating the construction of complex heterocyclic scaffolds. Its stability under standard conditions and compatibility with diverse reaction conditions make it a valuable building block for medicinal chemistry and material science applications. The compound is typically handled under inert conditions to preserve its amine functionality.
1804848-55-2 structure
Product Name:2-Bromo-4-methoxy-5-(trifluoromethoxy)aniline
CAS No:1804848-55-2
MF:C8H7BrF3NO2
MW:286.045892000198
CID:4974150
Update Time:2025-05-27
2-Bromo-4-methoxy-5-(trifluoromethoxy)aniline Chemical and Physical Properties
Names and Identifiers
-
- BrC1=C(N)C=C(C(=C1)OC)OC(F)(F)F
- 2-Bromo-4-methoxy-5-(trifluoromethoxy)aniline
-
- Inchi: 1S/C8H7BrF3NO2/c1-14-6-2-4(9)5(13)3-7(6)15-8(10,11)12/h2-3H,13H2,1H3
- InChI Key: FERVQOJSXHQSBS-UHFFFAOYSA-N
- SMILES: BrC1=CC(=C(C=C1N)OC(F)(F)F)OC
Computed Properties
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 15
- Rotatable Bond Count: 2
- Complexity: 215
- XLogP3: 3.1
- Topological Polar Surface Area: 44.5
2-Bromo-4-methoxy-5-(trifluoromethoxy)aniline Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Alichem | A013020605-250mg |
2-Bromo-4-methoxy-5-(trifluoromethoxy)aniline |
1804848-55-2 | 97% | 250mg |
475.20 USD | 2021-06-24 | |
| Alichem | A013020605-500mg |
2-Bromo-4-methoxy-5-(trifluoromethoxy)aniline |
1804848-55-2 | 97% | 500mg |
815.00 USD | 2021-06-24 | |
| Alichem | A013020605-1g |
2-Bromo-4-methoxy-5-(trifluoromethoxy)aniline |
1804848-55-2 | 97% | 1g |
1,445.30 USD | 2021-06-24 |
2-Bromo-4-methoxy-5-(trifluoromethoxy)aniline Related Literature
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Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
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3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
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Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
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