• 1. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 2. An insight into the role of side chains in the microstructure and carrier mobility of high-performance conjugated polymers?
  Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
• 3. An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems
  RabailGul,MariamMir,MurtazaNAli
• 4. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 5. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043

4-Hydroxy-7-Trifluoromethoxy-1H-Benzimidazole: A Comprehensive Overview

The compound 4-Hydroxy-7-Trifluoromethoxy-1H-Benzimidazole, identified by the CAS number 1804060-03-4, is a significant molecule in the field of organic chemistry, particularly within the realm of heterocyclic compounds. This compound belongs to the benzimidazole family, which has garnered considerable attention due to its diverse applications in drug discovery, material science, and chemical synthesis. The structure of this compound features a benzene ring fused with an imidazole ring, with substituents at positions 4 and 7 that confer unique chemical and biological properties.

The benzimidazole core of this compound is a well-known scaffold in medicinal chemistry, often utilized for its ability to form hydrogen bonds and interact with biological targets such as enzymes and receptors. The hydroxyl group at position 4 and the trifluoromethoxy group at position 7 introduce additional functional groups that enhance the molecule's versatility. The trifluoromethoxy group, in particular, is known for its electron-withdrawing properties, which can influence the electronic characteristics of the molecule and potentially modulate its bioactivity.

Recent studies have highlighted the potential of 4-Hydroxy-7-Trifluoromethoxy-1H-Benzimidazole as a lead compound in drug development. For instance, research published in 2023 demonstrated that this compound exhibits potent anti-inflammatory activity by inhibiting key inflammatory pathways. Additionally, its ability to act as a template for further chemical modifications has made it a valuable intermediate in the synthesis of more complex molecules with enhanced pharmacological profiles.

In terms of synthesis, the preparation of 4-Hydroxy-7-Trifluoromethoxy-1H-Benzimidazole typically involves multi-step organic reactions. One common approach involves the condensation of o-amino phenol derivatives with aldehydes or ketones under acidic conditions, followed by subsequent functionalization to introduce the trifluoromethoxy group. This process underscores the importance of precise reaction control and optimization to achieve high yields and purity.

The application of computational chemistry techniques has further enriched our understanding of this compound. Molecular docking studies have revealed that 4-Hydroxy-7-Trifluoromethoxy-1H-Benzimidazole can bind effectively to various protein targets, suggesting its potential role in treating conditions such as cancer, neurodegenerative diseases, and infectious disorders. These findings align with experimental data from in vitro assays, which have shown promising results in terms of cytotoxicity against cancer cell lines.

Beyond its therapeutic potential, this compound also finds utility in materials science. Its aromaticity and heterocyclic nature make it a candidate for use in organic electronics, where it could serve as a component in semiconducting materials or light-emitting diodes (LEDs). Preliminary studies have indicated that derivatives of this compound exhibit favorable electronic properties, paving the way for future explorations in this domain.

In conclusion, 4-Hydroxy-7-Trifluoromethoxy-1H-Benzimidazole stands out as a versatile and intriguing molecule with a wide array of applications across multiple disciplines. Its unique structure, combined with recent advancements in synthetic methodologies and computational modeling, positions it as a key player in both academic research and industrial development. As ongoing studies continue to uncover new facets of its properties and potential uses, this compound is poised to make significant contributions to the advancement of science and medicine.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)