• 1. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 2. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
• 3. Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires?
  Daniel Messmer,Stefan Salentinig,Jakob Heier Nanoscale, 2019,11, 6929-6938
• 4. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 5. Enantiopure 2,6-disubstituted piperidines bearing one alkene- or alkyne-containing substituent: preparation and application to total syntheses of indolizidine-alkaloids?
  Hui Liu,Deyong Su,Guolin Cheng,Jimin Xu,Xinyan Wang,Yuefei Hu Org. Biomol. Chem., 2010,8, 1899-1904

2,6-Diiodo-3-fluorotoluene (CAS No. 1803815-34-0): A Versatile Halogenated Aromatic Compound for Advanced Applications

2,6-Diiodo-3-fluorotoluene (CAS No. 1803815-34-0) is a halogenated aromatic compound that has gained significant attention in recent years due to its unique chemical properties and wide range of applications. As a derivative of toluene, this compound features two iodine atoms and one fluorine atom strategically positioned on the aromatic ring, making it an excellent building block for various synthetic transformations. The molecular formula of 2,6-diiodo-3-fluorotoluene is C7H5FI2, with a molecular weight of 361.92 g/mol.

The growing interest in fluorinated and iodinated aromatic compounds has been driven by their importance in pharmaceutical development, materials science, and organic synthesis. Researchers are particularly interested in how the electronic effects of fluorine and iodine substituents influence the reactivity of the aromatic ring. The 2,6-diiodo-3-fluorotoluene structure offers unique opportunities for selective functionalization, making it valuable for creating complex molecular architectures.

One of the most significant applications of 2,6-diiodo-3-fluorotoluene is in the field of pharmaceutical intermediates. The compound serves as a precursor for various active pharmaceutical ingredients (APIs), particularly those targeting central nervous system disorders and inflammatory conditions. The presence of both fluorine and iodine atoms allows for subsequent transformations through modern coupling reactions like Suzuki-Miyaura or Buchwald-Hartwig cross-couplings, which are frequently searched topics in organic chemistry forums and academic databases.

In materials science, 2,6-diiodo-3-fluorotoluene derivatives have shown promise in the development of organic electronic materials. The heavy iodine atoms contribute to enhanced spin-orbit coupling, making these compounds interesting candidates for organic light-emitting diodes (OLEDs) and other optoelectronic applications. Recent studies have explored how the fluorine substitution pattern affects the photophysical properties of resulting materials, a topic that has generated considerable discussion in materials science conferences.

The synthesis of 2,6-diiodo-3-fluorotoluene typically involves the selective iodination of 3-fluorotoluene under controlled conditions. This process requires careful optimization to achieve high regioselectivity and yield, which has been the subject of several recent publications in synthetic chemistry journals. The compound's crystalline structure and physical properties have been thoroughly characterized, with data available in major chemical databases that are frequently accessed by researchers worldwide.

From a commercial perspective, the demand for high-purity 2,6-diiodo-3-fluorotoluene has been steadily increasing, particularly from pharmaceutical and specialty chemical manufacturers. Suppliers have responded by developing improved purification methods to meet the stringent quality requirements of these industries. The global market for halogenated aromatic building blocks like this compound is expected to grow significantly in the coming years, driven by advancements in drug discovery and materials development.

Environmental and safety considerations for 2,6-diiodo-3-fluorotoluene handling have also been a focus of recent research. While the compound is stable under normal conditions, proper storage and handling procedures are essential to maintain its quality and prevent decomposition. These aspects are particularly important for researchers searching for safe handling practices for halogenated compounds, a common query in chemical safety databases.

The future outlook for 2,6-diiodo-3-fluorotoluene applications appears promising, with ongoing research exploring its potential in new areas such as catalysis and supramolecular chemistry. The compound's versatility as a synthetic intermediate continues to attract interest from both academic and industrial researchers, making it a valuable addition to the toolkit of modern organic chemistry.

For researchers working with polyhalogenated aromatic compounds, understanding the unique reactivity patterns of 2,6-diiodo-3-fluorotoluene is crucial. The compound's behavior in various reaction conditions has been the subject of detailed mechanistic studies, providing valuable insights that are frequently cited in advanced organic chemistry textbooks and review articles.

In analytical chemistry, methods for the precise quantification of 2,6-diiodo-3-fluorotoluene in complex mixtures have been developed using techniques such as HPLC and GC-MS. These analytical methods are important quality control tools for manufacturers and are often searched by quality assurance professionals in the chemical industry.

The patent landscape surrounding 2,6-diiodo-3-fluorotoluene derivatives has expanded significantly in recent years, particularly in the areas of medicinal chemistry and functional materials. This growth reflects the compound's importance as a key intermediate in innovative technologies, a trend that is expected to continue as new applications are discovered.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)