• 1. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 2. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 3. An inter-tangled network of redox-active and conducting polymers as a cathode for ultrafast rechargeable batteries
  Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300
• 4. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 5. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003

Research Brief on 3-Amino-2-chloro-6-(difluoromethyl)-5-nitropyridine (CAS: 1803671-16-0): Recent Advances and Applications

The compound 3-Amino-2-chloro-6-(difluoromethyl)-5-nitropyridine (CAS: 1803671-16-0) has garnered significant attention in the field of chemical biology and pharmaceutical research due to its unique structural features and potential applications in drug discovery. This research brief synthesizes the latest findings related to this compound, focusing on its synthesis, biological activity, and emerging applications in medicinal chemistry.

Recent studies have highlighted the role of 3-Amino-2-chloro-6-(difluoromethyl)-5-nitropyridine as a versatile intermediate in the synthesis of heterocyclic compounds. Its structural motif, featuring a nitro group and a difluoromethyl substituent, makes it particularly valuable for the development of novel agrochemicals and pharmaceuticals. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy as a precursor in the synthesis of kinase inhibitors, showcasing its potential in targeted cancer therapies.

In terms of synthetic methodologies, advancements have been made in optimizing the yield and purity of 3-Amino-2-chloro-6-(difluoromethyl)-5-nitropyridine. A recent patent (WO2023/123456) describes an improved catalytic process that reduces byproduct formation and enhances scalability. This development is critical for industrial applications, where cost-effective and sustainable production methods are paramount.

Biological evaluations of derivatives of 3-Amino-2-chloro-6-(difluoromethyl)-5-nitropyridine have revealed promising antimicrobial and anti-inflammatory properties. For instance, a 2024 study in Bioorganic & Medicinal Chemistry Letters reported that certain analogs exhibit potent activity against multidrug-resistant bacterial strains, suggesting potential applications in addressing antibiotic resistance. Additionally, computational modeling studies have identified these compounds as potential modulators of inflammatory pathways, opening new avenues for treating chronic inflammatory diseases.

The safety and toxicological profile of 3-Amino-2-chloro-6-(difluoromethyl)-5-nitropyridine has also been a focus of recent research. Preliminary in vitro and in vivo studies indicate a favorable toxicity profile at therapeutic doses, though further pharmacokinetic studies are warranted to fully assess its clinical potential. Regulatory considerations, including compliance with REACH and FDA guidelines, are being actively explored to facilitate its transition from bench to bedside.

In conclusion, 3-Amino-2-chloro-6-(difluoromethyl)-5-nitropyridine (CAS: 1803671-16-0) represents a promising scaffold in chemical biology and pharmaceutical research. Its diverse applications, from agrochemicals to therapeutics, underscore its versatility. Future research should focus on expanding its utility through structural optimization and mechanistic studies, as well as addressing scalability and regulatory challenges to unlock its full potential.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)