• 1. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 2. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 3. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 4. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
  Chem. Commun., 1997, 767-768
• 5. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991

• Solvents and Organic Chemicals Organic Compounds Organometallic compounds Organometalloid compounds Organosilicon compounds Alkylsilanes

Comprehensive Guide to 2-(cyclohexen-1-yl)ethynyl-trimethyl-silane (CAS No. 17988-44-2): Properties, Applications, and Industry Insights

2-(cyclohexen-1-yl)ethynyl-trimethyl-silane (CAS No. 17988-44-2) is a specialized organosilicon compound that has garnered significant attention in organic synthesis and material science. This compound, featuring a cyclohexenyl group linked to an ethynyl-trimethyl-silane moiety, is valued for its unique reactivity and versatility. Researchers and industry professionals frequently search for terms like "silylacetylene derivatives," "cyclohexenyl silane applications," and "CAS 17988-44-2 synthesis," reflecting its growing relevance in advanced chemical workflows.

The molecular structure of 2-(cyclohexen-1-yl)ethynyl-trimethyl-silane combines a cyclohexene ring with a terminal alkyne protected by a trimethylsilyl (TMS) group. This design enables selective transformations, making it a pivotal intermediate in cross-coupling reactions, click chemistry, and polymer modifications. Recent trends in sustainable chemistry have amplified interest in such silicon-based building blocks, as they often reduce waste and improve atom economy compared to traditional reagents.

One of the most searched questions about this compound revolves around its "role in pharmaceutical intermediates." Studies highlight its utility in constructing biologically active scaffolds, particularly in heterocycle synthesis for drug discovery. The TMS-ethynyl moiety acts as a masked alkyne, allowing controlled release under mild conditions—a feature critical for high-throughput screening and combinatorial chemistry. Additionally, its stability under various pH conditions makes it suitable for prodrug development.

In material science, 2-(cyclohexen-1-yl)ethynyl-trimethyl-silane is explored for surface functionalization and nanomaterial coatings. Its ability to form self-assembled monolayers (SAMs) on metal oxides aligns with the demand for anti-corrosive coatings and conductive polymers. Searches for "silane coupling agents" and "alkyne-surface modification" often cite this compound as a case study due to its balanced hydrophobicity and reactivity.

Environmental considerations are another hot topic tied to this chemical. Unlike heavier metal catalysts, silicon-based reagents like 17988-44-2 are increasingly favored for their lower ecological footprint. Queries such as "green chemistry alternatives for alkynes" and "non-toxic silane reagents" underscore this shift. The compound’s compatibility with solvent-free reactions and microwave-assisted synthesis further enhances its sustainability profile.

From a commercial perspective, suppliers and buyers often seek information on "scalable synthesis of 2-(cyclohexen-1-yl)ethynyl-trimethyl-silane" and "storage stability of TMS-alkynes." Proper handling under inert atmospheres and avoidance of protic solvents are key to maintaining its shelf life. The compound’s liquid state at room temperature and moderate viscosity facilitate precise dispensing in industrial settings.

Emerging applications in optoelectronics and organic LEDs (OLEDs) have also been linked to 17988-44-2. Its conjugated system potential enables energy-level tuning in semiconducting polymers, a topic frequently searched alongside "organic electronic materials." Researchers are investigating its incorporation into π-conjugated backbones to enhance charge transport properties.

In summary, 2-(cyclohexen-1-yl)ethynyl-trimethyl-silane (CAS No. 17988-44-2) bridges multiple disciplines—from medicinal chemistry to advanced materials. Its adaptability to modern catalytic systems and alignment with green chemistry principles ensure its continued prominence. For those exploring "functionalized alkynes" or "silicon-mediated transformations," this compound offers a compelling avenue for innovation.

• 56904-79-1(Silane, [(3E)-4-ethyl-3-octen-1-ynyl]trimethyl-)
• 851042-53-0(SILANE, [[2-(CYCLOPROPYLIDENEMETHYL)-1-CYCLOHEXEN-1-YL]ETHYNYL]TRIMETHYL-)
• 851042-55-2(SILANE, [[2-(CYCLOPENTYLIDENEMETHYL)-1-CYCLOHEXEN-1-YL]ETHYNYL]TRIMETHYL-)
• 2750-73-4(Silane, (4-ethyl-3-octen-1-ynyl)trimethyl- (7CI,8CI))
• 849799-70-8(2-NONENAL, 3-[(TRIMETHYLSILYL)ETHYNYL]-, (2Z)-)
• 849799-72-0(SILANE, [(3Z)-3-(2-BUTYNYLIDENE)-1-NONYNYL]TRIMETHYL-)
• 90753-22-3(Trimethyl(3-methylidenehept-1-yn-1-yl)silane)
• 2750-72-3(Silane, (4-ethyl-3-hepten-1-ynyl)trimethyl- (7CI,8CI))
• 110223-96-6(Silane, (4-methyl-3-decen-1-ynyl)trimethyl-, (E)-)
• 874439-58-4(Silane, trimethyl(3-methylene-1-dodecynyl)-)