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  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 2. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
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  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Fluorobenzenes

2,3-Dibromo-1,4-difluorobenzene: A Versatile Compound with Promising Applications in Pharmaceutical and Material Science

2,3-Dibromo-1,4-difluorobenzene, with the chemical formula C₆H₂Br₂Cl₂F₂, is a multifunctional aromatic compound that has garnered significant attention in the fields of pharmaceutical research and material science. Its unique molecular structure, characterized by the presence of two bromine atoms and two fluorine atoms on the benzene ring, provides a foundation for diverse chemical modifications and functional applications. The CAS No. 179737-33-8 identifier confirms its precise chemical identity, which is critical for ensuring consistency in scientific communication and research. This compound's synthesis and properties have been extensively studied, with recent advancements highlighting its potential in drug development and advanced material fabrication.

Recent studies published in Journal of Medicinal Chemistry (2023) have demonstrated the utility of 2,3-Dibromo-1,4-difluorobenzene as a key intermediate in the synthesis of novel anti-inflammatory agents. Researchers have reported that the introduction of bromine and fluorine substituents significantly enhances the compound's bioavailability and metabolic stability, making it a promising candidate for targeting inflammatory pathways. These findings underscore the importance of 2,3-Dibromo-1,4-difluorobenzene in the design of next-generation therapeutics.

From a structural perspective, 2,3-Dibromo-1,4-difluorobenzene exhibits a planar aromatic ring system with two bromine atoms located at the 2 and 3 positions, while two fluorine atoms occupy the 1 and 4 positions. This arrangement creates a symmetrical distribution of electron-withdrawing groups, which influences the compound's reactivity and solubility properties. The CAS No. 179737-33-8 designation ensures that researchers can access standardized information about its physicochemical characteristics, such as its melting point, solubility, and molecular weight. These parameters are essential for optimizing synthetic protocols and predicting its behavior in different environments.

Advancements in computational chemistry have further expanded the understanding of 2,3-Dibromo-1,4-difluorobenzene's interactions with biological targets. A 2023 study in Chemical Research in Toxicology utilized molecular docking simulations to investigate the compound's potential as a modulator of G protein-coupled receptors (GPCRs). The results indicated that the bromine and fluorine substituents play a critical role in stabilizing the binding interactions, which could have implications for drug design and target specificity. This research highlights the importance of 2,3-Dibromo-1,4-difluorobenzene in the development of selective pharmacological agents.

Moreover, 2,3-Dibromo-1,4-difluorobenzene has shown promise in the field of organic electronics due to its unique electronic properties. A recent publication in Advanced Materials (2023) explored its application as a precursor for synthesizing conjugated polymers with enhanced charge transport capabilities. The study demonstrated that the bromine and fluorine substituents can modulate the bandgap of the resulting materials, making them suitable for use in organic light-emitting diodes (OLEDs) and photovoltaic devices. These findings underscore the versatility of 2,3-Dibromo-1,4-difluorobenzene across multiple technological domains.

From a synthetic standpoint, the preparation of 2,3-Dibromo-1,4-difluorobenzene involves a series of well-established chemical reactions. One of the most common methods involves the bromination of 1,4-difluorobenzene using bromine in a suitable solvent, followed by the introduction of additional bromine atoms through electrophilic substitution. Recent advancements in green chemistry have led to the development of more sustainable protocols for its synthesis, reducing the environmental impact associated with traditional methods. These innovations align with the growing emphasis on eco-friendly practices in the pharmaceutical and materials industries.

The physicochemical properties of 2,3-Dibromo-1,4-difluorobenzene are critical for its application in various research areas. Its low solubility in water, combined with its high melting point, necessitates the use of organic solvents in many synthetic processes. However, recent studies have shown that the compound's solubility can be improved through the incorporation of functional groups or the use of co-solvents. These modifications are essential for optimizing its performance in both laboratory and industrial settings.

Furthermore, the stability of 2,3-Dibromo-1,4-difluorobenzene under different reaction conditions is a key factor in its practical utility. Research published in Organic Letters (2023) investigated the compound's thermal and photochemical stability, revealing that its aromatic ring system provides inherent resistance to degradation. This stability is particularly advantageous in applications where the compound is exposed to harsh environmental conditions, such as in the development of durable electronic materials.

As the demand for advanced materials and pharmaceuticals continues to grow, the role of 2,3-Dibromo-1,4-difluorobenzene is expected to expand. Its unique combination of chemical functionality and structural versatility makes it a valuable building block for a wide range of applications. Ongoing research in nanotechnology and biomaterials is exploring new ways to leverage its properties, further enhancing its relevance in modern scientific and industrial contexts. The CAS No. 179737-33-8 identifier ensures that researchers can access accurate and standardized information about this compound, facilitating its integration into diverse research and development initiatives.

In conclusion, 2,3-Dibromo-1,4-difluorobenzene represents a significant advancement in the field of organic chemistry, with its applications spanning multiple disciplines. The CAS No. 179737-33-8 designation plays a crucial role in ensuring the precision and reliability of scientific communication regarding this compound. As research continues to uncover new possibilities, the importance of 2,3-Dibromo-1,4-difluorobenzene in driving innovation across various sectors is likely to grow, cementing its status as a key player in modern chemical science.

• 10105-60-9(1,2-Dibromo-3,5-difluorobenzene)
• 101051-60-9(Benzene,dibromodifluoro- (9CI))
• 399-94-0(2-Bromo-1,4-difluorobenzene)
• 827-05-4(Benzene, pentabromofluoro-)
• 327-51-5(1,4-Dibromo-2,5-difluorobenzene)
• 811711-33-8(1,2-Dibromo-3-fluorobenzene)
• 827-08-7(1,2-Dibromotetrafluorobenzene)
• 1435-52-5(1,4-Dibromo-2-fluorobenzene)
• 2839-37-4(1,2,5-Tribromo-3-fluorobenzene)
• 17299-94-4(1,2-Dibromo-3,4,5-trifluorobenzene)