• 1. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 2. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
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• 3. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Fluorobenzenes

Comprehensive Overview of 1-(3-fluorophenyl)cyclobutane-1-carboxylic acid (CAS No. 179411-84-8)

1-(3-fluorophenyl)cyclobutane-1-carboxylic acid (CAS No. 179411-84-8) is a fluorinated cyclobutane derivative with significant applications in pharmaceutical and chemical research. This compound, characterized by its cyclobutane ring and fluorophenyl moiety, has garnered attention due to its unique structural properties and potential as a building block in drug discovery. Researchers are increasingly exploring its role in the synthesis of bioactive molecules, particularly in the development of small-molecule inhibitors and proteolysis-targeting chimeras (PROTACs), which are currently trending in the field of targeted protein degradation.

The fluorine atom in the 3-fluorophenyl group enhances the compound's metabolic stability and binding affinity, making it a valuable scaffold in medicinal chemistry. Recent studies highlight its utility in optimizing pharmacokinetic properties, a topic frequently searched by professionals in drug development forums. Additionally, its carboxylic acid functionality allows for further derivatization, enabling the creation of amides, esters, and other derivatives with tailored properties. This versatility aligns with the growing demand for custom synthesis and high-value intermediates in the pharmaceutical industry.

From an analytical perspective, 1-(3-fluorophenyl)cyclobutane-1-carboxylic acid is often analyzed using HPLC, NMR, and mass spectrometry, techniques commonly queried in scientific databases. Its purity and stability under various conditions are critical for reproducibility in research, a concern frequently raised in quality control discussions. The compound's logP and solubility data are also of interest to formulators working on drug delivery systems, another hot topic in contemporary research.

In the context of green chemistry, efforts to synthesize 1-(3-fluorophenyl)cyclobutane-1-carboxylic acid via catalytic methods or flow chemistry have gained traction, reflecting the industry's shift toward sustainable practices. Searches for eco-friendly synthesis and waste reduction in organic chemistry underscore the relevance of such advancements. Furthermore, the compound's potential applications in bioconjugation and peptide modification are being explored, addressing the rising interest in chemical biology tools.

As a research chemical, 1-(3-fluorophenyl)cyclobutane-1-carboxylic acid is typically supplied with detailed certificates of analysis (CoA) and technical data sheets (TDS), ensuring compliance with regulatory standards. Its handling and storage recommendations are often searched by laboratory personnel, emphasizing the need for clear safety protocols. While not classified as hazardous, proper personal protective equipment (PPE) is advised during use, a reminder echoed in workplace safety guidelines.

The compound's role in structure-activity relationship (SAR) studies is another area of interest, particularly for researchers investigating GPCR targets or enzyme modulators. Online forums and academic platforms frequently feature discussions on optimizing lead compounds, where 1-(3-fluorophenyl)cyclobutane-1-carboxylic acid serves as a reference. Its compatibility with high-throughput screening (HTS) workflows further enhances its appeal in modern drug discovery pipelines.

In summary, 1-(3-fluorophenyl)cyclobutane-1-carboxylic acid (CAS No. 179411-84-8) is a multifaceted compound with broad applicability in pharmaceutical research, chemical synthesis, and material science. Its alignment with current trends such as targeted therapy, sustainable chemistry, and precision medicine ensures its continued relevance in scientific literature and industrial applications. Researchers and suppliers alike prioritize its availability, underscoring its importance as a high-potential intermediate in the global market.

• 214262-97-2(1-(3-Fluorophenyl)cyclopentanecarboxylic acid)
• 1249568-55-5(1-(3,5-difluorophenyl)cyclobutane-1-carboxylic acid)
• 2091271-08-6(Cyclopropanecarboxylic acid, 1-(3-fluorophenyl)-2,2-dimethyl-)
• 66504-02-7(1,2-Cyclopropanedicarboxylic acid, 1-(3-fluorophenyl)-, (1R,2S)-rel-)
• 151157-46-9(1-(4-Fluorophenyl)cyclobutanecarboxylic acid)
• 1314713-36-4(1-(3-fluoro-5-methylphenyl)cyclobutane-1-carboxylic acid)
• 1486179-53-6(5-(4-fluorophenyl)spiro2.3hexane-5-carboxylic acid)
• 1522124-13-5(1-(4-fluorophenyl)-3,3-dimethylcyclobutane-1-carboxylic acid)
• 633317-58-5(1-(3,4-difluorophenyl)cyclobutane-1-carboxylic acid)
• 214262-98-3(1-(3-Fluorophenyl)cyclohexanecarboxylic acid)