• 1. An investigation of new infrared nonlinear optical material: BaCdSnSe4, and three new related centrosymmetric compounds: Ba2SnSe4, Mg2GeSe4, and Ba2Ge2S6?
  Kui Wu,Zhihua Yang,Shilie Pan Dalton Trans., 2015,44, 19856-19864
• 2. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 3. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 4. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 5. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034

Methyl 2-Fluoro-6-methoxybenzoate (CAS No: 178747-79-0)

Methyl 2-Fluoro-6-methoxybenzoate, with the CAS number 178747-79-0, is a versatile organic compound that has garnered significant attention in the fields of pharmaceutical chemistry, material science, and organic synthesis. This compound is characterized by its unique structure, which includes a methyl ester group attached to a benzoate ring substituted with a fluoro and methoxy group at the 2 and 6 positions, respectively. The combination of these substituents imparts distinctive chemical properties, making it a valuable building block in various synthetic pathways.

Methyl 2-Fluoro-6-methoxybenzoate is widely recognized for its role in the synthesis of biologically active compounds. Recent studies have highlighted its potential as an intermediate in the development of novel pharmaceutical agents, particularly in the areas of anti-inflammatory and anti-cancer drug discovery. The fluoro group at the 2-position contributes to the compound's lipophilicity, enhancing its ability to cross biological membranes, while the methoxy group at the 6-position introduces electronic effects that can modulate the compound's reactivity and bioavailability.

The synthesis of Methyl 2-Fluoro-6-methoxybenzoate typically involves multi-step organic reactions, often starting from readily available aromatic precursors. One common approach involves the Friedel-Crafts acylation followed by esterification or methylation steps. Researchers have also explored alternative methods, such as microwave-assisted synthesis and catalytic processes, to optimize yield and purity. These advancements have significantly streamlined the production of this compound, making it more accessible for large-scale applications.

In terms of applications, Methyl 2-Fluoro-6-methoxybenzoate has found utility in diverse industries. In pharmaceuticals, it serves as a key intermediate in the synthesis of complex molecules with therapeutic potential. For instance, recent studies have demonstrated its role in the development of selective inhibitors for kinases involved in cancer progression. Additionally, this compound has been employed in agrochemical research to design novel pesticides with enhanced efficacy and reduced environmental impact.

The physical properties of Methyl 2-Fluoro-6-methoxybenzoate are well-documented, including its melting point, boiling point, and solubility characteristics. These properties are critical in determining its suitability for various synthetic transformations and industrial applications. For example, its high solubility in organic solvents facilitates its use in solution-phase reactions, while its thermal stability ensures compatibility with high-temperature processes.

From an environmental perspective, Methyl 2-Fluoro-6-methoxybenzoate has been evaluated for its biodegradability and ecological impact. Studies indicate that it undergoes efficient microbial degradation under aerobic conditions, minimizing its persistence in aquatic environments. This makes it a more sustainable choice compared to other synthetic intermediates that may pose long-term environmental risks.

In conclusion, Methyl 2-Fluoro-6-methoxybenzoate (CAS No: 178747-79-0) stands out as a pivotal compound in modern organic chemistry due to its unique structure and versatile applications. Its role as an intermediate in drug discovery and material science continues to expand with advancements in synthetic methodologies and an increased focus on sustainability. As research progresses, this compound is expected to unlock new possibilities across various industries, solidifying its position as a cornerstone in contemporary chemical innovation.

• 355809-52-8(2-methyl-1,3-phenylene bis(2-fluorobenzoate))
• 926025-95-8(Benzoic acid, 2-[(2,4-difluorophenyl)methoxy]-, methyl ester)
• 1534389-85-9(Methyl 2,4-difluoro-6-methoxybenzoate)
• 622849-28-9(BENZOIC ACID, 2-(3-FLUORO-2-FORMYLPHENOXY)-5-METHOXY-, METHYL ESTER)
• 816454-65-6(Benzoic acid, 2-fluoro-6-phenoxy-, methyl ester)
• 1806533-02-7(Ethyl 2,4-dimethoxy-6-fluorobenzoate)
• 773136-55-3(Ethyl 2-Fluoro-6-methoxybenzoate)
• 941608-36-2(2-Benzyloxy-6-Fluoro-Benzoic Acid)
• 72373-81-0(Methyl 2-fluoro-6-hydroxybenzoate)
• 773876-05-4(2,3-Difluoro-6-methoxybenzoic acid methyl ester)