• 1. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
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• 3. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
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• 4. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
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• 5. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Research Briefing on Carbamic Acid Derivative (CAS: 177213-61-5) and Its Applications in Chemical Biology and Medicine

The compound with CAS number 177213-61-5, chemically named Carbamic acid, 1,4-butanediylbis[(3-aminopropyl)-,bis(1,1-dimethylethyl) ester, has recently gained attention in chemical biology and pharmaceutical research due to its unique structural properties and potential therapeutic applications. This briefing synthesizes the latest findings on this molecule, focusing on its synthesis, biological activities, and emerging applications in drug development.

Recent studies have highlighted the role of 177213-61-5 as a versatile building block in medicinal chemistry. Its structure features two tert-butyl carbamate-protected amino groups linked by a butylene spacer, making it particularly useful for constructing drug-like molecules with improved pharmacokinetic properties. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its effectiveness as a precursor in the synthesis of novel protease inhibitors, showing promising activity against several viral targets.

In the field of drug delivery, researchers have explored the use of this carbamic acid derivative as a component of pH-sensitive prodrug systems. The tert-butyl protecting groups provide stability under physiological conditions while allowing controlled release of active compounds in acidic environments such as tumor tissues or intracellular compartments. This property was successfully utilized in a recent cancer therapy development project, where the molecule served as a linker between cytotoxic agents and targeting antibodies.

From a synthetic chemistry perspective, several improved preparation methods for 177213-61-5 have been reported in the past two years. A 2024 publication in Organic Process Research & Development described an optimized large-scale synthesis with higher yields (85-90%) and reduced environmental impact compared to previous routes. These advances have made the compound more accessible for both academic research and industrial applications.

Emerging research suggests potential neurological applications for derivatives of this carbamic acid compound. Preliminary in vitro studies indicate that certain structural analogs may modulate neurotransmitter systems, particularly those involving GABAergic signaling. While these findings are still in early stages, they open new avenues for developing treatments for neurological disorders.

The safety profile of 177213-61-5 has been evaluated in several recent toxicological studies. Current data suggest low acute toxicity (LD50 > 2000 mg/kg in rodent models) and minimal genotoxic potential, supporting its use in pharmaceutical development. However, researchers emphasize the need for comprehensive metabolite identification studies, as the breakdown products of this compound in biological systems are not yet fully characterized.

Looking forward, the scientific community anticipates expanded applications of this carbamic acid derivative in areas such as targeted protein degradation and antibody-drug conjugates. Its chemical versatility and favorable properties position it as a valuable tool in modern drug discovery pipelines. Continued research efforts are expected to further elucidate its potential and limitations in various therapeutic contexts.

• 114459-62-0(Tris-Boc-spermine)
• 885268-91-7(Carbamic acid,(3-aminopropyl)butyl-, 1,1-dimethylethyl ester (9CI))
• 99560-07-3(2,6,11,15-Tetraazahexadecanedioic acid,6,11-bis[(1,1-dimethylethoxy)carbonyl]-, bis(1,1-dimethylethyl) ester)
• 196613-57-7(Tert-butyl 4-aminoazepane-1-carboxylate)
• 182576-24-5(Carbamic acid, (4-aminobutyl)(3-aminopropyl)-, 1,1-dimethylethyl ester)
• 1174020-26-8(tert-butyl (4R)-4-aminoazepane-1-carboxylate)
• 878630-84-3(tert-butyl (4S)-4-aminoazepane-1-carboxylate)
• 86953-79-9(tert-Butyl pyrrolidine-1-carboxylate)
• 123387-52-0(tert-Butyl Azepane-1-carboxylate)
• 68076-39-1(N1,N5-Bis-Boc-spermidine)