• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Exclusive self-aligned β-phase PVDF films with abnormal piezoelectric coefficient prepared via phase inversion?
  N. Soin,D. Boyer,K. Prashanthi,S. Sharma,A. A. Narasimulu,J. Luo,T. H. Shah,E. Siores,T. Thundat Chem. Commun., 2015,51, 8257-8260
• 3. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 4. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 5. Distinctive size effects of Pt nanoparticles immobilized on Fe3O4@PPy used as an efficient recyclable catalyst for benzylic alcohol aerobic oxidation and hydrogenation reduction of nitroaromatics
  Yu Long,Bing Yuan,Jianrui Niu,Xin Tong,Jiantai Ma New J. Chem., 2015,39, 1179-1185

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Acetals
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Acetals

Comprehensive Guide to 2,2,3,3-Tetramethoxybutane (CAS No. 176798-33-7): Properties, Applications, and Industry Insights

2,2,3,3-Tetramethoxybutane (CAS No. 176798-33-7) is a specialized organic compound widely recognized for its unique molecular structure and versatile applications in industrial and research settings. This tetramethoxy derivative belongs to the class of ether compounds, characterized by four methoxy groups attached to a butane backbone. Its chemical formula, C₈H₁₈O₄, and molecular weight of 178.23 g/mol make it a valuable intermediate in synthetic chemistry. Recent trends in green chemistry and sustainable solvents have sparked renewed interest in this compound due to its potential as a low-toxicity alternative in formulations.

The synthesis of 2,2,3,3-Tetramethoxybutane typically involves the acid-catalyzed reaction of butanedione with methanol, yielding a high-purity product with excellent stability. Analytical techniques such as GC-MS and NMR spectroscopy confirm its structural integrity, with characteristic peaks at 3.3 ppm (methoxy protons) and 1.2 ppm (methylene protons) in ¹H-NMR spectra. Researchers frequently search for "2,2,3,3-Tetramethoxybutane solubility" data, which reveals good miscibility with common organic solvents like ethanol, acetone, and dichloromethane but limited solubility in water (0.5 g/L at 20°C).

In pharmaceutical applications, this compound serves as a protecting group reagent for sensitive functional groups during multi-step syntheses. Its ability to form stable acetal linkages makes it particularly useful in carbohydrate chemistry and nucleoside modifications. Industry professionals often inquire about "2,2,3,3-Tetramethoxybutane price" and "bulk suppliers," reflecting its growing demand in API production. The compound's role in flavor and fragrance formulations has also gained attention, where it acts as a slow-release carrier for volatile aroma compounds.

Material science applications leverage 2,2,3,3-Tetramethoxybutane as a crosslinking agent in polymer chemistry. When combined with epoxy resins or polyurethanes, it enhances thermal stability and mechanical properties of the final products. Recent patents highlight its use in UV-curable coatings, addressing the market need for environmentally friendly alternatives to traditional solvents. Laboratory safety data shows favorable profiles compared to similar compounds, with LD₅₀ values >2000 mg/kg (oral, rat), making it a preferred choice in industrial hygiene-conscious environments.

Emerging research explores the compound's potential in energy storage systems, particularly as an electrolyte additive for lithium-ion batteries. Its ability to stabilize electrode interfaces aligns with the global push for high-performance batteries. Analytical chemists frequently search for "2,2,3,3-Tetramethoxybutane HPLC method" to develop quality control protocols, with reverse-phase C18 columns and acetonitrile/water mobile phases proving most effective. The compound's shelf life (>24 months under nitrogen at 4°C) and compatibility with standard laboratory equipment contribute to its reliability in long-term studies.

Environmental considerations position 2,2,3,3-Tetramethoxybutane favorably in REACH compliance assessments, with biodegradation studies showing >60% mineralization in 28 days (OECD 301B). This characteristic, combined with low bioaccumulation potential (log P_ow = 0.89), makes it attractive for industries transitioning to eco-friendly chemicals. Technical inquiries often focus on "scaling up 2,2,3,3-Tetramethoxybutane production," where continuous flow reactors demonstrate improved yields (>85%) compared to batch processes.

Future applications may exploit the compound's chiral properties (meso-form) in asymmetric catalysis, particularly in pharmaceutical intermediates where enantioselectivity is crucial. The growing fine chemicals market, projected to reach $210 billion by 2027, will likely drive innovation in derivative development. Current research publications emphasize its utility in click chemistry reactions and metal-organic frameworks (MOFs), expanding its relevance in cutting-edge material design.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)