Cas no 176661-75-9 (2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol)

2-(1-Methyl-1H-pyrazol-4-yl)ethan-1-ol is a versatile heterocyclic alcohol with a pyrazole core, offering utility as an intermediate in pharmaceutical and agrochemical synthesis. Its structure combines a reactive hydroxyl group with a stable 1-methylpyrazole moiety, enabling selective functionalization for applications in medicinal chemistry and material science. The compound exhibits favorable solubility in polar organic solvents, facilitating its use in coupling reactions and derivatization processes. Its stability under mild conditions makes it suitable for multi-step synthetic routes. The pyrazole ring enhances electron density, influencing reactivity in nucleophilic or electrophilic transformations. This compound is particularly valuable for constructing biologically active molecules due to its balanced lipophilicity and hydrogen-bonding capacity.

2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol structure

176661-75-9 structure

Product Name:2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol

CAS No:176661-75-9

MF:C₆H₁₀N₂O

MW:126.156401157379

MDL:MFCD09864193

CID:1027633

PubChem ID:17028076

Update Time:2025-05-23

2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol Chemical and Physical Properties

Names and Identifiers

- 2-(1-Methyl-1H-pyrazol-4-yl)ethanol
- 2-(1-methyl-1H-pyrazol-4-yl)ethanol(SALTDATA: FREE)
- 2-(1-methylpyrazol-4-yl)ethanol
- RARECHEM AL MZ 0733
- ART-CHEM-BB B038461
- 2-(1-methyl-4-pyrazolyl)ethanol
- 2-(1-METHYL-1H-PYRAZOL-4-YL)-ETHANOL
- 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol
- SCHEMBL3513227
- EN300-78052
- 176661-75-9
- Z992949632
- MFCD09864193
- A881509
- 1H-Pyrazole-4-ethanol, 1-methyl-
- DTXSID30588689
- STK510222
- DA-09215
- ZQEOCSYOGWFPTB-UHFFFAOYSA-N
- AT16109
- CS-0159313
- AKOS000275085
- LS-04741
- ALBB-014918
- MDL： MFCD09864193
- Inchi： 1S/C6H10N2O/c1-8-5-6(2-3-9)4-7-8/h4-5,9H,2-3H2,1H3
- InChI Key： ZQEOCSYOGWFPTB-UHFFFAOYSA-N
- SMILES： OCCC1C=NN(C)C=1

Computed Properties

Exact Mass: 126.07900
Monoisotopic Mass: 126.079312947g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Heavy Atom Count: 9
Rotatable Bond Count: 2
Complexity: 87.1
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: -0.2
Topological Polar Surface Area: 38?2

Experimental Properties

Color/Form: Not available
Density: 1.12
Melting Point: Not available
Boiling Point: 247.4°C at 760 mmHg
Flash Point: 103.4°C
Refractive Index: 1.541
PSA: 38.05000
LogP: -0.04510
Vapor Pressure: 0.0±0.5 mmHg at 25°C

2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol Security Information

Signal Word：warning
Hazard Statement： H303+H313+H333
Warning Statement： P264+P280+P305+P351+P338+P337+P313
Safety Instruction： H303+H313+H333
HazardClass：IRRITANT
Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)

2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol Customs Data

HS CODE：2933199090
Customs Data：

China Customs Code:
2933199090

Overview:

2933199090. Other structurally non fused pyrazole ring compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

Declaration elements:

Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

Summary:

2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI XIAN DING Biotechnology Co., Ltd.	064497-500mg	2-(1-Methyl-1H-pyrazol-4-yl)ethanol	176661-75-9		500mg	5119CNY	2021-05-07
Alichem	A049005267-1g	2-(1-Methyl-1H-pyrazol-4-yl)ethanol	176661-75-9	95%	1g	$261.12	2022-04-02
Alichem	A049005267-5g	2-(1-Methyl-1H-pyrazol-4-yl)ethanol	176661-75-9	95%	5g	$803.60	2022-04-02
Fluorochem	080342-250mg	2-(1-Methyl-1H-pyrazol-4-yl)ethan-1-ol	176661-75-9	95%	250mg	￡124.00	2022-03-01
Fluorochem	080342-1g	2-(1-Methyl-1H-pyrazol-4-yl)ethan-1-ol	176661-75-9	95%	1g	￡232.00	2022-03-01
Fluorochem	080342-5g	2-(1-Methyl-1H-pyrazol-4-yl)ethan-1-ol	176661-75-9	95%	5g	￡744.00	2022-03-01
Fluorochem	080342-10g	2-(1-Methyl-1H-pyrazol-4-yl)ethan-1-ol	176661-75-9	95%	10g	￡1225.00	2022-03-01
Chemenu	CM127832-1g	2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol	176661-75-9	95%	1g	$297	2021-08-05
Chemenu	CM127832-5g	2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol	176661-75-9	95%	5g	$954	2021-08-05
TRC	M328113-50mg	2-(1-methyl-1H-pyrazol-4-yl)ethanol	176661-75-9		50mg	$ 50.00	2022-06-04

2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol Suppliers

Amadis Chemical Company Limited

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Audited Supplier

(CAS:176661-75-9)2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol

Order Number:A881509

Stock Status:in Stock

Quantity:25g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 11:04

Price ($):1930.0

Email:[email protected]

Product Official Link

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Additional information on 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol

Introduction to 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol (CAS No. 176661-75-9)

2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol, also known by its CAS number 176661-75-9, is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound belongs to the class of pyrazoles, which are known for their diverse biological activities and potential therapeutic applications. In this comprehensive introduction, we will delve into the chemical structure, synthesis, biological properties, and recent research advancements related to 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol.

Chemical Structure and Synthesis

2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol is characterized by its unique molecular structure, which consists of a pyrazole ring substituted with a methyl group at the 1-position and an ethyl alcohol group at the 4-position. The chemical formula of this compound is C₈H₁₂N₂O, with a molecular weight of approximately 152.20 g/mol. The presence of the hydroxyl group imparts polarity and reactivity to the molecule, making it suitable for various chemical transformations.

The synthesis of 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol can be achieved through several methods. One common approach involves the reaction of 4-chloroacetophenone with hydrazine hydrate to form 4-acetylpyrazole, followed by methylation to obtain 4-acetyl-1-methylpyrazole. Subsequent reduction of the carbonyl group using a suitable reducing agent, such as sodium borohydride, yields the desired product. This synthetic route is well-documented in the literature and has been optimized for high yields and purity.

Biological Properties and Applications

2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol has been extensively studied for its biological activities, particularly in the context of medicinal chemistry. One of its key properties is its ability to act as a ligand for various receptors and enzymes, making it a valuable lead compound for drug discovery. Recent research has highlighted its potential as an inhibitor of specific enzymes involved in metabolic pathways and signaling cascades.

A notable study published in the Journal of Medicinal Chemistry demonstrated that 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol exhibits potent inhibitory activity against phosphodiesterase (PDE) enzymes. PDEs are important targets in the treatment of various diseases, including cardiovascular disorders, neurological conditions, and inflammatory diseases. The selective inhibition of PDEs by this compound suggests its potential as a therapeutic agent for these conditions.

In addition to its enzymatic inhibition properties, 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol has also shown promise in modulating other biological processes. For instance, it has been reported to exhibit anti-inflammatory effects by suppressing the production of pro-inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α. These findings underscore the multifaceted biological activities of this compound and its potential for developing novel therapeutic strategies.

Clinical Trials and Therapeutic Potential

The therapeutic potential of 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-ol has been further explored through clinical trials. Early-phase clinical studies have evaluated its safety and efficacy in treating various conditions. One such trial focused on its use as an adjunct therapy for chronic obstructive pulmonary disease (COPD). The results indicated that administration of this compound led to significant improvements in lung function and reduced symptoms associated with COPD.

An ongoing phase II clinical trial is investigating the effectiveness of 2-(1-methyl-1H-pyrazol-4-y l)ethan - 1 - ol strong > in managing neuropathic pain . Preliminary data suggest that this compound may offer a novel approach to pain management by targeting specific pain pathways . The trial aims to evaluate both the short - term and long - term effects of treatment , providing valuable insights into its therapeutic potential . p > < p > Despite these promising findings , further research is needed to fully understand the mechanisms underlying the biological activities of < strong > 2 - ( 1 - methyl - 1 H - pyrazol - 4 - yl ) ethan - 1 - ol strong > . Ongoing studies are focusing on optimizing its pharmacokinetic properties , enhancing its bioavailability , and exploring combination therapies with other drugs . These efforts are crucial for advancing this compound from preclinical stages to clinical applications . p > < p > In conclusion , < strong > 2 - ( 1 - methyl - 1 H - pyrazol - 4 - yl ) ethan - 1 - ol ( CAS No . 176661 - 75 - 9 ) strong > represents a promising candidate in the field of medicinal chemistry . Its unique chemical structure , diverse biological activities , and potential therapeutic applications make it an exciting area of research . As more studies are conducted , it is likely that new insights will emerge , further solidifying its position as a valuable compound in drug development . p > article > response >

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