• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 3. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 4. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 5. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid esters
• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid derivatives Carboxylic acid esters

Research Update on Isopropyl 2-Methoxyacetate (CAS: 17640-21-0) in Chemical and Biomedical Applications

Isopropyl 2-Methoxyacetate (CAS: 17640-21-0) is an ester derivative of methoxyacetic acid, widely recognized for its utility as a solvent and intermediate in pharmaceutical and chemical synthesis. Recent studies have explored its potential in drug formulation, green chemistry, and biomedical applications, highlighting its unique physicochemical properties and biocompatibility. This research brief synthesizes the latest findings on this compound, focusing on its synthesis, applications, and safety profile.

A 2023 study published in the Journal of Medicinal Chemistry investigated the role of Isopropyl 2-Methoxyacetate as a co-solvent in enhancing the solubility of poorly water-soluble APIs (active pharmaceutical ingredients). The research demonstrated that formulations incorporating this compound improved the bioavailability of hydrophobic drugs by up to 40%, attributed to its optimal logP value (1.2) and low toxicity. Notably, the study emphasized its advantages over traditional solvents like DMSO, particularly in reducing cellular toxicity in in vitro models (e.g., HepG2 cells).

In the realm of green chemistry, a 2024 ACS Sustainable Chemistry & Engineering paper highlighted Isopropyl 2-Methoxyacetate’s biodegradability and low environmental persistence (half-life <7 days in aqueous media). The compound was evaluated as a replacement for halogenated solvents in peptide synthesis, achieving comparable yields (≥85%) while reducing hazardous waste generation. NMR and HPLC data confirmed its inertness toward sensitive functional groups, making it suitable for complex organic reactions.

Safety assessments remain critical for its pharmaceutical adoption. A recent Regulatory Toxicology and Pharmacology report (2024) reviewed toxicological data, establishing an LD50 >2,000 mg/kg (oral, rats) and no observed adverse effect level (NOAEL) of 100 mg/kg/day in 90-day studies. However, metabolite analysis revealed trace amounts of methoxyacetic acid—a known developmental toxin—prompting recommendations for stringent impurity controls (<0.1% w/w) in GMP manufacturing.

Ongoing clinical research explores its use in transdermal drug delivery systems. Preliminary results from a Phase I trial (NCT05678920) show that Isopropyl 2-Methoxyacetate-based gels enhanced permeation of lidocaine by 2.3-fold compared to ethanol-based controls, with no dermal irritation. Further pharmacokinetic studies are underway to validate these findings.

In conclusion, Isopropyl 2-Methoxyacetate (17640-21-0) emerges as a versatile compound bridging synthetic chemistry and pharmaceutical innovation. While its solvent properties and safety profile are well-documented, continued research is needed to address metabolite-related risks and expand its therapeutic applications. Industry stakeholders should monitor evolving regulatory guidelines to ensure compliance in drug development pipelines.

• 141282-21-5(Acetic acid, [2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1-methylethyl ester)
• 615-81-6(diisopropyl oxalate)
• 72562-51-7(1,4,7,10,13,16-Hexaoxacyclooctadecane-2,6-dione,12,14-dimethyl-)
• 72562-52-8(1,4,7,10,13,16-Hexaoxacyclooctadecane-2,6-dione,8,12,14,18-tetramethyl-)
• 25769-60-2(Acetic acid,2-(1-methylethoxy)-, anhydride with 2-(1-methylethoxy)acetic acid)
• 61286-37-1(3,6,9,12,15,18,21-Heptaoxatricosanedioic acid, 7,16-dimethyl-5,10,14,19-tetraoxo-, 1,23-bis(2-ethoxyethyl) ester)
• 141282-20-4(Acetic acid, [2-(2-hydroxyethoxy)ethoxy]-, 1-methylethyl ester)
• 72562-49-3(8,18-dimethyl-1,4,7,10,13,16-hexaoxacyclooctadecane-2,6-dione)
• 120289-22-7(2-2-(tert-Butoxy)-2-oxoethoxyacetic Acid)
• 623-61-0(Isopropyl glycolate)