• 1. Bis-porphyrin arrays. Part 1. The synthesis of meso-halophenyl porphyrin-α-diones
  Richard Beavington,Paul L. Burn J. Chem. Soc. Perkin Trans. 1 1999 583
• 2. Synthesis, characterization, and structures of oxovanadium(v) complexes of Schiff bases of β-amino alcohols as tunable catalysts for the asymmetric oxidation of organic sulfides and asymmetric alkynylation of aldehydes
  Sheng-Hsiung Hsieh,Ya-Pei Kuo,Han-Mou Gau Dalton Trans. 2007 97
• 3. Sterically hindered selenoether ligands: palladium(ii) complexes as catalytic activators for Suzuki–Miyaura coupling
  Umesh Kumar,Pooja Dubey,Ved Vati Singh,Om Prakash,Ajai K. Singh RSC Adv. 2014 4 41659
• 4. Photoluminescence properties of tetrahedral zinc(ii) complexes supported by calix[4]arene-based salicylaldiminato ligands
  Steve Ullmann,René Schnorr,Christian Laube,Bernd Abel,Berthold Kersting Dalton Trans. 2018 47 5801
• 5. Mechanosynthesis and photophysics of colour-tunable photoluminescent group 13 metal complexes with sterically demanding salen and salophen ligands
  Felix Leon,Chenfei Li,Javier F. Reynes,Varun K. Singh,Xiao Lian,How Chee Ong,Gavin Hum,Handong Sun,Felipe García Faraday Discuss. 2023 241 63

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropanes

Introduction to 3,5-Di-tert-butylbenzaldehyde (CAS No. 17610-00-3) and Its Applications in Modern Chemical Research

3,5-Di-tert-butylbenzaldehyde, with the chemical formula C??H??O and CAS number 17610-00-3, is a prominent aromatic aldehyde that has garnered significant attention in the field of organic synthesis and pharmaceutical chemistry. This compound, characterized by its bulky tert-butyl groups at the 3rd and 5th positions of the benzene ring, exhibits unique electronic and steric properties that make it a valuable intermediate in the development of various chemical entities. The presence of these electron-withdrawing groups enhances its reactivity, making it a versatile building block for synthesizing more complex molecules.

The synthesis of 3,5-Di-tert-butylbenzaldehyde typically involves the oxidation of corresponding methyl derivatives or the Friedel-Crafts acylation followed by reduction. Its stability under a range of reaction conditions further underscores its utility in multi-step synthetic pathways. Recent advancements in catalytic methods have enabled more efficient and environmentally benign routes to this compound, aligning with the growing emphasis on sustainable chemistry practices.

In the realm of pharmaceutical research, 3,5-Di-tert-butylbenzaldehyde has been explored as a precursor for biologically active molecules. Its structural motif is reminiscent of several pharmacophores found in therapeutic agents, particularly those targeting neurological and inflammatory disorders. For instance, derivatives of this compound have shown promise in modulating enzyme activity and receptor binding interactions. Studies have demonstrated its potential in developing novel antioxidant and anti-inflammatory agents, leveraging its ability to scavenge reactive oxygen species due to the phenolic character introduced by aldehyde functionality.

Moreover, the application of 3,5-Di-tert-butylbenzaldehyde extends beyond pharmaceuticals into materials science. Its aromatic structure and rigidity make it a candidate for designing liquid crystals and organic semiconductors. Researchers have investigated its incorporation into polymer matrices to enhance thermal stability and mechanical strength. The bulky tert-butyl groups contribute to steric hindrance, which can be exploited to fine-tune material properties such as crystallinity and melting points.

Recent publications highlight the role of 3,5-Di-tert-butylbenzaldehyde in medicinal chemistry through its use as a scaffold for drug discovery. Computational modeling studies have identified its derivatives as candidates for inhibiting protein-protein interactions involved in cancer progression. The aldehyde group provides a reactive site for further functionalization, allowing chemists to tailor molecular properties such as solubility and bioavailability. This flexibility has led to the development of novel protease inhibitors and kinase inhibitors, which are critical targets in oncology research.

The compound's unique electronic distribution also makes it an interesting candidate for photophysical studies. Its fluorescence properties have been explored in developing sensors for detecting metal ions and other small molecules. The high quantum yield of certain derivatives makes them suitable for bioimaging applications, where precise molecular recognition is essential for diagnostic purposes.

In conclusion, 3,5-Di-tert-butylbenzaldehyde (CAS No. 17610-00-3) stands as a multifaceted compound with broad utility across multiple scientific disciplines. Its synthesis continues to be refined through innovative methodologies, while its applications in drug development, materials science, and analytical chemistry are being increasingly recognized. As research progresses, the full potential of this versatile intermediate is likely to be further unlocked, contributing significantly to advancements in chemical science.

• 939-97-9(4-Tert-Butylbenzaldehyde)
• 94464-94-5(Benzaldehyde, 4-(diphenylmethyl)-)
• 122-03-2(4-Isopropylbenzaldehyde)
• 180740-69-6(1,3-Benzenedicarboxaldehyde, 5-(1,1-dimethylethyl)-)
• 23039-28-3(3-tert-Butylbenzaldehyde)
• 943-27-1(4′-tert-Butylacetophenone)
• 34246-57-6(3-Isopropylbenzaldehyde)
• 1756-31-6(Ethanone, 1-[3,5-bis(1,1-dimethylethyl)phenyl]-)
• 6136-71-6(1-(3-tert-butylphenyl)ethan-1-one)
• 112538-48-4(3,5-Diisopropylbenzaldehyde)