• 1. Distribution pattern and allocation of defects in hydrogenated ZnO thin films?
  Vitaly Gurylev,Chung-Yi Su,Tsong-Pyng Perng Phys. Chem. Chem. Phys., 2016,18, 16033-16038
• 2. Estimation of hydrogen sulfide from crude petroleum: a unique invention using a simple chemosensor?
  Shampa Kundu,Prithidipa Sahoo New J. Chem., 2019,43, 12369-12374
• 3. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151
• 5. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

Introduction to 2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine (CAS No. 175277-67-5)

2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine, identified by the Chemical Abstracts Service Number (CAS No.) 175277-67-5, is a significant compound in the realm of pharmaceutical and agrochemical research. This heterocyclic amine features a pyridine core substituted with two chlorine atoms at the 2- and 6-positions, and a trifluoromethyl group at the 4-position, along with an amine functional group at the 3-position. The unique structural arrangement of this molecule imparts distinct chemical properties that make it a valuable intermediate in synthetic chemistry and a promising candidate for developing novel bioactive molecules.

The molecular structure of 2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine contributes to its reactivity and potential applications. The presence of electron-withdrawing groups such as chlorine and trifluoromethyl enhances its interaction with biological targets, making it an attractive scaffold for drug design. In particular, the trifluoromethyl group is known to improve metabolic stability and binding affinity, which are critical factors in pharmaceutical development. This compound’s versatility has been explored in various research settings, including the synthesis of kinase inhibitors, antiviral agents, and herbicides.

Recent advancements in medicinal chemistry have highlighted the importance of pyridine derivatives in drug discovery. A notable application of 2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine is in the development of small-molecule inhibitors targeting protein kinases, which play a crucial role in cell signaling pathways associated with diseases such as cancer. Studies have demonstrated that substituents like chlorine and trifluoromethyl can modulate the binding affinity of kinase inhibitors by influencing electronic distributions and steric interactions. The amine group at the 3-position further provides a site for further functionalization, allowing for the creation of libraries of derivatives with tailored biological activities.

In agrochemical research, 2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine has been investigated as a precursor for herbicidal compounds. The structural features of this molecule contribute to its ability to disrupt essential plant metabolic pathways, offering potential as a selective herbicide. Researchers have leveraged its reactivity to develop novel compounds that exhibit improved efficacy against weeds while maintaining low toxicity to crops. The integration of computational modeling and high-throughput screening has accelerated the discovery process, enabling rapid optimization of lead compounds derived from this scaffold.

The synthesis of 2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine involves multi-step organic reactions that require careful control of reaction conditions to achieve high yields and purity. Common synthetic routes include nucleophilic substitution reactions on halogenated pyridines followed by functional group transformations such as trifluoromethylation and amination. Advances in catalytic systems have improved the efficiency and selectivity of these reactions, making it feasible to produce this compound on scales suitable for industrial applications. The growing demand for high-quality intermediates like 2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine underscores its importance in modern chemical manufacturing.

The pharmacological potential of 2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine has been further explored through preclinical studies. These investigations have revealed promising activities against various therapeutic targets, including enzymes involved in inflammation and infectious diseases. The compound’s ability to interact with biological macromolecules suggests its utility in developing treatments for conditions where modulation of protein function is desired. Collaborative efforts between academic institutions and pharmaceutical companies have facilitated the translation of laboratory findings into clinical candidates, demonstrating the translational relevance of this molecule.

From a computational chemistry perspective, 2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine serves as an excellent model system for studying molecular interactions. Advanced computational methods such as molecular dynamics simulations and quantum mechanical calculations have provided insights into its binding mode with biological targets. These studies not only aid in rational drug design but also contribute to our fundamental understanding of structure-function relationships in drug discovery. The integration of experimental data with computational predictions has become indispensable in modern medicinal chemistry workflows.

The agrochemical applications of 2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine extend beyond herbicides to include fungicides and insecticides. Its structural framework allows for modifications that enhance activity against specific pests or pathogens while minimizing environmental impact. Regulatory considerations play a critical role in ensuring that agrochemicals derived from this compound meet safety standards for both human health and ecological systems. Ongoing research focuses on developing sustainable synthetic routes that align with green chemistry principles.

In conclusion,2,6-Dichloro-4-(trifluoromethyl)pyridin-3-aminesignificant role as an intermediate in pharmaceutical and agrochemical research is well-documented by recent advancements across multiple disciplines. Its unique structural features enable diverse applications ranging from drug development to crop protection strategies, underscoring its versatility as a chemical building block, while ongoing research continues to uncover new possibilities for leveraging its potential, contributing significantly to innovation in chemical sciences.

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