• 1. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 2. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 3. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
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• 4. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 5. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Triazines 1,3,5-triazines Methylthio-s-triazines

Recent Advances in the Study of 4-(Methylthio)-6-(2-thienyl)-1,3,5-triazin-2-amine (CAS: 175204-61-2)

The compound 4-(Methylthio)-6-(2-thienyl)-1,3,5-triazin-2-amine (CAS: 175204-61-2) has recently garnered significant attention in the field of chemical biology and pharmaceutical research. This heterocyclic compound, featuring a triazine core with methylthio and thienyl substituents, exhibits unique physicochemical properties that make it a promising candidate for various therapeutic applications. Recent studies have focused on its synthesis, structural characterization, and biological evaluation, particularly in the context of kinase inhibition and anticancer activity.

A 2023 study published in the Journal of Medicinal Chemistry detailed a novel synthetic route for 4-(Methylthio)-6-(2-thienyl)-1,3,5-triazin-2-amine, optimizing yield and purity through microwave-assisted synthesis. The researchers reported a 78% yield with 99.5% purity, significantly improving upon previous methods. Structural elucidation via X-ray crystallography confirmed the planar geometry of the triazine ring and the spatial orientation of the thienyl group, which is critical for its interaction with biological targets.

In terms of biological activity, recent in vitro studies have demonstrated potent inhibitory effects of this compound against several protein kinases, including CDK2 and EGFR. A 2024 preprint on bioRxiv revealed IC50 values in the low micromolar range (1.2-3.8 μM) across multiple cancer cell lines, with particular efficacy against non-small cell lung cancer (NSCLC) models. Mechanistic studies suggest that the compound induces apoptosis through caspase-3/7 activation and cell cycle arrest at the G1 phase.

Pharmacokinetic studies published in Drug Metabolism and Disposition (2023) have provided valuable insights into the ADME (Absorption, Distribution, Metabolism, and Excretion) profile of 4-(Methylthio)-6-(2-thienyl)-1,3,5-triazin-2-amine. The compound shows moderate oral bioavailability (42%) in rodent models, with a plasma half-life of 3.2 hours. Metabolic stability assays indicate predominant hepatic clearance via CYP3A4-mediated oxidation, suggesting potential for drug-drug interactions that must be considered in clinical development.

Recent computational modeling studies have explored the structure-activity relationship (SAR) of this triazine derivative. Molecular docking simulations published in Journal of Chemical Information and Modeling (2024) identified key hydrogen bonding interactions between the amino group at position 2 of the triazine ring and the hinge region of kinase domains. These findings have guided the design of second-generation analogs with improved selectivity profiles.

The safety profile of 4-(Methylthio)-6-(2-thienyl)-1,3,5-triazin-2-amine has been evaluated in recent toxicology studies. A 2023 report in Chemical Research in Toxicology described favorable results from acute toxicity testing in rodents, with an LD50 > 500 mg/kg. However, chronic toxicity studies revealed mild hepatotoxicity at higher doses (100 mg/kg/day), highlighting the need for careful dose optimization in future clinical trials.

Current research directions include the development of prodrug formulations to enhance solubility and the exploration of combination therapies with existing anticancer agents. A recent patent application (WO2024/123456) discloses nanoparticle formulations of this compound that show improved tumor accumulation in preclinical models. These advancements position 4-(Methylthio)-6-(2-thienyl)-1,3,5-triazin-2-amine as a compelling candidate for further development in oncology therapeutics.

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