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  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 2. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

Research Brief on Methyl 2-Methoxybiphenyl-4-carboxylate (CAS: 175152-72-4): Recent Advances and Applications

Methyl 2-Methoxybiphenyl-4-carboxylate (CAS: 175152-72-4) is a key intermediate in the synthesis of various bioactive compounds, particularly in the pharmaceutical and agrochemical industries. Recent studies have highlighted its significance in the development of novel therapeutic agents, owing to its versatile chemical structure and functional groups. This research brief aims to summarize the latest findings related to this compound, focusing on its synthesis, applications, and potential in drug discovery.

Recent literature indicates that Methyl 2-Methoxybiphenyl-4-carboxylate has been employed as a building block in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules. A study published in the Journal of Medicinal Chemistry (2023) demonstrated its utility in the development of COX-2 inhibitors, which are critical for managing inflammation and pain. The compound's methoxy and carboxylate groups facilitate selective binding to enzyme active sites, enhancing the efficacy of the resulting drugs.

In addition to its pharmaceutical applications, Methyl 2-Methoxybiphenyl-4-carboxylate has been investigated for its role in agrochemicals. A 2024 study in the Journal of Agricultural and Food Chemistry reported its use in the synthesis of herbicidal compounds with improved environmental stability and target specificity. The researchers emphasized the compound's potential to reduce the ecological footprint of conventional herbicides while maintaining high efficacy.

From a synthetic chemistry perspective, advancements in catalytic methods have streamlined the production of Methyl 2-Methoxybiphenyl-4-carboxylate. A recent publication in Organic Letters (2023) described a palladium-catalyzed cross-coupling reaction that significantly improves yield and reduces by-products. This methodological innovation is expected to lower production costs and enhance scalability for industrial applications.

Despite these promising developments, challenges remain in optimizing the compound's pharmacokinetic properties and minimizing potential side effects. Ongoing research is exploring structural modifications to enhance bioavailability and reduce toxicity. Collaborative efforts between academic institutions and pharmaceutical companies are expected to drive further innovations in this area.

In conclusion, Methyl 2-Methoxybiphenyl-4-carboxylate (CAS: 175152-72-4) continues to be a valuable compound in chemical biology and drug development. Its diverse applications, coupled with recent synthetic advancements, underscore its importance in the field. Future research should focus on expanding its therapeutic potential and addressing existing limitations to fully realize its benefits.

• 90266-91-4(Benzoic acid, 4-methoxy-, [1,1'-biphenyl]-2,5-diyl ester (9CI))
• 1262009-58-4([1,1'-Biphenyl]-3,4'-dicarboxylic acid, 2'-methoxy-, 3-methyl ester)
• 89901-00-8([1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 2'-METHOXY-, METHYL ESTER)
• 364079-19-6(Benzoic acid, 4-hydroxy-, [1,1'-biphenyl]-2,5-diyl ester)
• 1261903-15-4(4-(4-Methoxycarbonylphenyl)-3-methoxybenzoic acid)
• 90266-92-5(Benzoic acid, 4-ethoxy-, [1,1'-biphenyl]-2,5-diyl ester (9CI))
• 406233-36-1(4-Formyl-2-methoxybiphenyl-4-carboxylic acid methyl ester)
• 4712-73-6(6,6'-Dihydroxy-3,3'-biphenyldicarboxylic acid; Di-Me ether, di-Me ester)
• 175152-49-5([1,1'-Biphenyl]-4-carboxylic acid, 2-methoxy-2'-methyl-, methyl ester)
• 1261993-18-3(4-(4-Ethoxycarbonylphenyl)-3-methoxybenzoic acid)