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Comprehensive Overview of 3-Chloro-4-methylthiophene-2-carbohydrazide (CAS No. 175137-12-9): Properties, Applications, and Industry Insights

3-Chloro-4-methylthiophene-2-carbohydrazide (CAS No. 175137-12-9) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. This thiophene derivative combines a chloro substituent at the 3-position and a methyl group at the 4-position, along with a reactive carbohydrazide functional group, making it a versatile intermediate for synthesizing biologically active molecules.

Recent trends in drug discovery highlight the growing demand for thiophene-based scaffolds, as they exhibit remarkable pharmacological properties. Researchers are particularly interested in 3-Chloro-4-methylthiophene-2-carbohydrazide for its potential role in developing antimicrobial agents and anticancer compounds. A 2023 study published in the Journal of Medicinal Chemistry emphasized how such derivatives could address antibiotic resistance—a top-priority global health challenge.

From a synthetic chemistry perspective, the carbohydrazide moiety in this compound enables diverse transformations, including condensation reactions to form hydrazones or azole heterocycles. These reactions are critical for creating molecular libraries in high-throughput screening programs. Industry reports indicate a 15% annual growth in the market for fine chemical intermediates like CAS No. 175137-12-9, driven by innovations in precision agriculture and personalized medicine.

Environmental considerations also shape the discourse around this compound. Regulatory agencies increasingly favor green chemistry approaches for synthesizing halogenated thiophenes. Manufacturers now optimize processes to minimize waste, leveraging catalytic methodologies and solvent-free conditions—topics frequently searched in ACS Sustainable Chemistry forums.

Analytical characterization of 3-Chloro-4-methylthiophene-2-carbohydrazide typically involves HPLC purity testing (≥98%) and spectroscopic techniques (FT-IR, NMR). Its crystalline form has been studied via X-ray diffraction, revealing intermolecular hydrogen bonding patterns that influence solubility—a key parameter for formulation scientists.

Emerging applications include its use as a ligand precursor in metal-organic frameworks (MOFs) for gas storage—a hot topic in materials science communities. Patent databases show a 40% increase in filings related to thiophene-carbohydrazide hybrids since 2020, underscoring their commercial relevance.

For procurement specialists, understanding supply chain dynamics is crucial. Major producers of CAS No. 175137-12-9 are concentrated in Asia-Pacific regions, with stringent GMP compliance requirements. Quality control documents should always specify residual solvent levels and heavy metal content—common concerns raised in pharmaceutical QA/QC discussions.

Future research directions may explore computational modeling of this compound’s ADMET properties (Absorption, Distribution, Metabolism, Excretion, Toxicity) using AI-driven platforms—a trending search term in cheminformatics circles. Such studies could accelerate its adoption in targeted therapy development.

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