Cas no 174469-04-6 ((7-chloro-2,3-dihydrofuro2,3-cpyridin-3-yl)methanol)

(7-Chloro-2,3-dihydrofuro[2,3-c]pyridin-3-yl)methanol is a heterocyclic compound featuring a fused furan-pyridine core with a hydroxymethyl substituent at the 3-position and a chlorine atom at the 7-position. This structure imparts versatility as a synthetic intermediate in pharmaceutical and agrochemical applications. The presence of both chloro and hydroxymethyl functional groups allows for further derivatization, enabling the synthesis of more complex molecules. Its rigid bicyclic framework may contribute to enhanced binding affinity in biologically active compounds. The compound is typically handled under controlled conditions due to its reactive sites. Suitable purification methods, such as chromatography or recrystallization, ensure high purity for research and industrial use.
(7-chloro-2,3-dihydrofuro2,3-cpyridin-3-yl)methanol structure
174469-04-6 structure
Product Name:(7-chloro-2,3-dihydrofuro2,3-cpyridin-3-yl)methanol
CAS No:174469-04-6
MF:C8H8ClNO2
MW:185.607621192932
MDL:MFCD17012758
CID:1367727
PubChem ID:19703002
Update Time:2025-11-02

(7-chloro-2,3-dihydrofuro2,3-cpyridin-3-yl)methanol Chemical and Physical Properties

Names and Identifiers

    • Furo[2,3-c]pyridine-3-methanol, 7-chloro-2,3-dihydro-
    • (7-CHLORO-2,3-DIHYDROFURO[2,3-C]PYRIDIN-3-YL)METHANOL
    • 7-chloro-2,3-dihydro-Furo[2,3-c]pyridine-3-methanol
    • {7-chloro-2H,3H-furo[2,3-c]pyridin-3-yl}methanol
    • 174469-04-6
    • SCHEMBL6701988
    • DTXSID90599337
    • F12592
    • MFCD17012758
    • DA-09270
    • CS-0139723
    • (7-chloro-2,3-dihydrofuro2,3-cpyridin-3-yl)methanol
    • MDL: MFCD17012758
    • Inchi: 1S/C8H8ClNO2/c9-8-7-6(1-2-10-8)5(3-11)4-12-7/h1-2,5,11H,3-4H2
    • InChI Key: REMOMHARFSPPEX-UHFFFAOYSA-N
    • SMILES: ClC1C2=C(C=CN=1)C(CO)CO2

Computed Properties

  • Exact Mass: 185.02444
  • Monoisotopic Mass: 185.0243562g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 1
  • Complexity: 167
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.9
  • Topological Polar Surface Area: 42.4?2

Experimental Properties

  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 304.2±42.0 °C at 760 mmHg
  • Flash Point: 137.8±27.9 °C
  • PSA: 42.35
  • Vapor Pressure: 0.0±0.7 mmHg at 25°C

(7-chloro-2,3-dihydrofuro2,3-cpyridin-3-yl)methanol Security Information

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Additional information on (7-chloro-2,3-dihydrofuro2,3-cpyridin-3-yl)methanol

Comprehensive Overview of (7-Chloro-2,3-dihydrofuro[2,3-c]pyridin-3-yl)methanol (CAS No. 174469-04-6)

(7-Chloro-2,3-dihydrofuro[2,3-c]pyridin-3-yl)methanol (CAS No. 174469-04-6) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research. This compound, characterized by its unique furopyridine backbone, plays a pivotal role in the development of novel therapeutic agents. Its molecular structure, featuring a chloro-substituted ring and a hydroxymethyl functional group, makes it a versatile intermediate in synthetic chemistry.

The growing interest in heterocyclic compounds like (7-chloro-2,3-dihydrofuro[2,3-c]pyridin-3-yl)methanol is driven by their potential applications in drug discovery. Researchers are particularly intrigued by its ability to serve as a building block for bioactive molecules, especially in the fields of central nervous system (CNS) therapeutics and anti-inflammatory agents. Recent studies have explored its utility in designing inhibitors for specific enzymes, aligning with the current trend of targeted drug development.

One of the most frequently asked questions about CAS No. 174469-04-6 is its solubility and stability under various conditions. This compound exhibits moderate solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) and methanol, which is crucial for its handling in laboratory settings. Stability studies indicate that it remains intact at room temperature, though prolonged exposure to light or moisture should be avoided to prevent degradation.

In the context of green chemistry, (7-chloro-2,3-dihydrofuro[2,3-c]pyridin-3-yl)methanol has been evaluated for its environmental impact. Modern synthetic routes aim to minimize waste and utilize catalytic processes, reflecting the industry's shift toward sustainable practices. This aligns with the increasing demand for eco-friendly chemical synthesis, a hot topic among researchers and manufacturers alike.

The pharmaceutical industry's focus on small-molecule therapeutics has further elevated the importance of this compound. Its furopyridine scaffold is a key motif in several drug candidates undergoing clinical trials. For instance, derivatives of (7-chloro-2,3-dihydrofuro[2,3-c]pyridin-3-yl)methanol have shown promise in modulating neurotransmitter activity, addressing conditions like anxiety and depression—a trending area in mental health research.

From a commercial perspective, the global market for fine chemicals and pharmaceutical intermediates is expanding, with CAS No. 174469-04-6 being no exception. Suppliers and manufacturers are increasingly listing this compound in their catalogs, catering to the rising demand from academic and industrial laboratories. Its pricing and availability are often discussed in forums dedicated to chemical sourcing, highlighting its relevance in the supply chain.

Analytical techniques such as nuclear magnetic resonance (NMR) and high-performance liquid chromatography (HPLC) are commonly employed to characterize (7-chloro-2,3-dihydrofuro[2,3-c]pyridin-3-yl)methanol. These methods ensure purity and confirm structural integrity, which are critical for its application in high-stakes research. The compound's spectral data is often shared in scientific databases, aiding reproducibility—a cornerstone of modern open science initiatives.

Looking ahead, the versatility of (7-chloro-2,3-dihydrofuro[2,3-c]pyridin-3-yl)methanol positions it as a valuable asset in medicinal chemistry. Its potential to yield new derivatives with enhanced bioactivity continues to inspire innovation. As the scientific community delves deeper into structure-activity relationships (SAR), this compound is likely to remain a focal point in the quest for next-generation therapeutics.

In summary, (7-chloro-2,3-dihydrofuro[2,3-c]pyridin-3-yl)methanol (CAS No. 174469-04-6) exemplifies the intersection of chemistry and pharmacology. Its unique properties, coupled with its applicability in cutting-edge research, make it a compound worth watching. Whether you're a synthetic chemist, a pharmaceutical researcher, or a supplier in the chemical industry, understanding this molecule's potential can open doors to exciting opportunities.

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