• 1. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 2. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 4. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 5. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Aminoquinolines and derivatives

Comprehensive Overview of 3-Isoquinolinamine, N-methyl-(9CI) (CAS No. 171861-48-6): Properties, Applications, and Research Insights

3-Isoquinolinamine, N-methyl-(9CI) (CAS No. 171861-48-6) is a specialized organic compound belonging to the isoquinoline family, a class of heterocyclic aromatic compounds with significant relevance in pharmaceutical and material science research. This compound, characterized by its methyl-substituted amine group at the 3-position of the isoquinoline backbone, has garnered attention for its potential applications in drug discovery, agrochemical development, and advanced material synthesis. Its molecular structure, C₁₀H₁₀N₂, offers a versatile scaffold for further chemical modifications, making it a valuable intermediate in synthetic chemistry.

In recent years, the demand for isoquinoline derivatives like N-methyl-3-isoquinolinamine has surged due to their role in designing bioactive molecules. Researchers are particularly interested in its potential as a pharmacophore in central nervous system (CNS) therapeutics, given the structural similarities to other neurologically active compounds. The compound’s CAS number 171861-48-6 serves as a critical identifier in chemical databases, ensuring precise tracking in global supply chains and regulatory documentation.

The synthesis of 3-Isoquinolinamine, N-methyl-(9CI) typically involves multi-step organic reactions, including cyclization and methylation processes. Advanced techniques such as microwave-assisted synthesis and catalytic hydrogenation have been explored to improve yield and purity. Analytical methods like HPLC and NMR spectroscopy are routinely employed to verify its structural integrity, with purity grades often exceeding 98% for research applications.

From an industrial perspective, this compound aligns with the growing trend of green chemistry and sustainable synthesis. Companies are increasingly adopting solvent-free reactions and biocatalysts to produce such intermediates, addressing environmental concerns while maintaining cost efficiency. Its stability under standard storage conditions (room temperature, inert atmosphere) further enhances its practicality for large-scale use.

Emerging studies highlight the role of CAS 171861-48-6 in developing fluorescent probes for biochemical assays, leveraging its inherent photophysical properties. Additionally, computational chemistry models predict its utility in metal-organic frameworks (MOFs), a hot topic in materials science for gas storage and catalysis applications. These interdisciplinary connections make it a compound of interest in both academic and industrial R&D sectors.

For researchers sourcing N-methyl-3-isoquinolinamine, key considerations include supplier reliability, batch-to-batch consistency, and compliance with REACH or FDA guidelines. FAQs in scientific forums often address its solubility profile (e.g., in DMSO or ethanol) and compatibility with common coupling reagents like EDCI or HOBt. Such practical insights are critical for experimental success.

In summary, 3-Isoquinolinamine, N-methyl-(9CI) (CAS No. 171861-48-6) represents a dynamic intersection of chemistry and innovation. Its adaptability across multiple domains—from medicinal chemistry to smart materials—positions it as a compound worthy of continued exploration. As synthetic methodologies evolve and applications expand, this isoquinoline derivative is poised to play a pivotal role in addressing contemporary scientific challenges.

• 52430-43-0(N-Methylquinolin-2-amine)
• 5683-33-0(N,N-Dimethylpyridin-2-amine)
• 4597-87-9(2-(methylamino)pyridine)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)