• 1. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 2. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 3. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 4. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 5. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932

Introduction to 3-Iodo-1-tosylindole (CAS No. 170456-80-1)

3-Iodo-1-tosylindole, with the CAS number 170456-80-1, is a versatile compound that has gained significant attention in the fields of medicinal chemistry and organic synthesis. This compound is characterized by its unique structural features, which include an indole core, an iodine substituent, and a tosyl group. These functionalities make it a valuable intermediate in the synthesis of various bioactive molecules and pharmaceuticals.

The indole scaffold is a fundamental building block in the development of numerous drugs due to its biological activity and structural diversity. The presence of the iodine substituent in 3-Iodo-1-tosylindole provides a handle for further functionalization through various chemical transformations, such as cross-coupling reactions. The tosyl group, on the other hand, serves as a good leaving group, facilitating nucleophilic substitution reactions and enabling the synthesis of complex molecules with high efficiency.

Recent advancements in synthetic methodologies have further expanded the utility of 3-Iodo-1-tosylindole. For instance, palladium-catalyzed cross-coupling reactions have been widely employed to introduce a variety of functional groups at the iodine position. This has led to the development of novel compounds with potential therapeutic applications in areas such as oncology, neurology, and cardiovascular diseases.

In addition to its role as a synthetic intermediate, 3-Iodo-1-tosylindole has been explored for its biological activities. Studies have shown that derivatives of this compound exhibit potent inhibitory effects on specific enzymes and receptors, making them promising candidates for drug discovery. For example, certain derivatives have demonstrated selective inhibition of protein kinases, which are key targets in cancer therapy.

The pharmacological properties of 3-Iodo-1-tosylindole and its derivatives have also been investigated in preclinical studies. These studies have provided valuable insights into their mechanism of action, pharmacokinetics, and safety profiles. The results have been encouraging, with several compounds showing favorable pharmacological properties and low toxicity.

Beyond its direct applications in drug discovery, 3-Iodo-1-tosylindole has also found use in other areas of chemical research. For instance, it has been utilized as a starting material for the synthesis of fluorescent probes and imaging agents. These probes are essential tools in cellular and molecular biology, enabling researchers to visualize and study various biological processes with high precision.

The versatility of 3-Iodo-1-tosylindole is further highlighted by its application in combinatorial chemistry. High-throughput screening techniques have been employed to rapidly generate large libraries of compounds derived from this scaffold. This approach has accelerated the identification of lead compounds with desired biological activities, streamlining the drug discovery process.

In conclusion, 3-Iodo-1-tosylindole (CAS No. 170456-80-1) is a highly valuable compound with a wide range of applications in medicinal chemistry and organic synthesis. Its unique structural features and functional groups make it an excellent starting material for the synthesis of bioactive molecules and pharmaceuticals. Ongoing research continues to uncover new possibilities for this compound, solidifying its importance in the scientific community.

• 8033-69-0(3-Iodo-1-(phenylsulfonyl)indole)
• 551951-03-2(3,6-diiodo-9-(4-methylphenyl)sulfonylcarbazole)
• 887115-55-1(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine)
• 80360-14-1(3-Iodo-1-(phenylsulfonyl)-1H-indole)
• 1217335-95-9(1H-Indole, 6-iodo-1-[(4-methylphenyl)sulfonyl]-)
• 582305-43-9(5-Bromo-3-iodo-1-(phenylsulfonyl)indole)
• 102855-25-4(1H-Indole, 4-iodo-1-[(4-methylphenyl)sulfonyl]-)
• 142688-28-6(5-bromo-3-iodo-1-tosyl-1H-indole)
• 676273-39-5(3-Iodo-1-tosyl-1H-indole-5-carbonitrile)
• 882562-73-4(3-Iodo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[3,2-c]pyridine)