• 1. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 2. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 3. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 4. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 5. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119

4-Chloro-5-Fluoro-1H-Indole: A Comprehensive Overview

4-Chloro-5-fluoro-1H-indole, with the CAS number 169674-02-6, is a heterocyclic aromatic compound that has garnered significant attention in various fields of chemistry and materials science. This compound is characterized by its indole core, a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. The presence of chlorine and fluorine substituents at the 4th and 5th positions, respectively, imparts unique electronic and steric properties to the molecule, making it a valuable building block in organic synthesis.

The synthesis of 4-chloro-5-fluoro-1H-indole typically involves multi-step processes, often utilizing directed metallation or substitution strategies. Recent advancements in catalytic methods have enabled more efficient and selective routes to this compound, reducing production costs and enhancing its accessibility for research and industrial applications. Its structure has been exploited in the development of novel materials, including organic semiconductors and optoelectronic devices.

One of the most promising applications of 4-chloro-5-fluoro-1H-indole lies in the field of drug discovery. Researchers have demonstrated that this compound exhibits potential as a lead molecule for anti-cancer therapies due to its ability to modulate key cellular pathways. For instance, studies have shown that it can inhibit specific kinase enzymes involved in tumor growth and metastasis. These findings highlight its role as a valuable scaffold for medicinal chemistry.

In addition to its pharmacological applications, 4-chloro-5-fluoro-1H-indole has found utility in materials science. Its electronic properties make it suitable for use in organic light-emitting diodes (OLEDs) and other optoelectronic devices. Recent research has focused on incorporating this compound into conjugated polymers, where it enhances charge transport properties and improves device efficiency. Such applications underscore its versatility as a functional material.

The chemical stability of 4-chloro-5-fluoro-1H-indole under various conditions has also been extensively studied. Its resistance to oxidative degradation makes it an ideal candidate for use in harsh chemical environments. Furthermore, its solubility properties have been optimized through structural modifications, enabling its use in diverse solvent systems.

In conclusion, 4-chloro-5-fluoro-1H-indole (CAS No: 169674-02-6) is a versatile compound with a wide range of applications across multiple disciplines. From drug discovery to materials science, its unique chemical properties continue to drive innovative research and development efforts. As new methodologies emerge for its synthesis and application, this compound is poised to play an increasingly important role in advancing modern science and technology.

• 1133116-09-2(7-Chloro-8-fluoroquinoline)
• 391-82-2(4-Chloro-7-fluoroquinoline)
• 376646-56-9(5-Chloro-4-fluoro-1H-indole)
• 122509-72-2(6-chloro-5-fluoro-1H-indole)
• 391-77-5(4-Chloro-6-fluoroquinoline)
• 908600-76-0(4,6-dichloro-5-fluoro-1H-Indole)
• 885520-88-7(6-Chloro-4-fluoro-1H-indole)
• 918490-51-4(7-chloro-6-fluoroisoquinoline)
• 169674-57-1(5-Chloro-6-fluoro-1H-indole)
• 885520-79-6(4-Chloro-6-fluoro-1H-indole)