• 1. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 2. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 3. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 4. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 5. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers

Comprehensive Guide to 6-Ethoxy-2,3-difluorobenzaldehyde (CAS No. 167684-02-8): Properties, Applications, and Industry Insights

6-Ethoxy-2,3-difluorobenzaldehyde (CAS No. 167684-02-8) is a specialized organic compound gaining attention in pharmaceutical and agrochemical research. This fluorinated benzaldehyde derivative features a unique molecular structure with an ethoxy group at the 6-position and fluorine atoms at the 2- and 3-positions, making it a valuable intermediate for synthesizing complex molecules. Its high purity grade (>98%) and thermal stability (decomposition point: 210°C) cater to demanding applications in drug discovery and material science.

Recent studies highlight the compound's role in developing next-generation antimicrobial agents, aligning with global concerns about antibiotic resistance. Researchers are exploring its potential as a building block for non-steroidal anti-inflammatory drugs (NSAIDs), leveraging its fluorine atoms to enhance bioavailability. The electron-withdrawing effects of the fluorine substituents also make it attractive for designing OLED materials, responding to the booming demand for flexible displays.

From a synthetic chemistry perspective, 6-Ethoxy-2,3-difluorobenzaldehyde demonstrates remarkable reactivity in Pd-catalyzed cross-coupling reactions, a hot topic in green chemistry forums. Its low ecotoxicity profile (OECD 301D ready biodegradability tests ongoing) addresses growing environmental regulations, while the ethoxy-difluoro combination shows promise in modulating lipophilicity for CNS-targeting pharmaceuticals – a frequent search term in medicinal chemistry databases.

Analytical data reveals distinctive characteristics: 1H NMR (400 MHz, CDCl3) shows aldehydic proton at δ 10.25 ppm and aromatic protons between δ 7.15-7.45 ppm, while 19F NMR displays two distinct fluorines at δ -112.3 and -118.6 ppm. These spectral fingerprints aid in quality control during scale-up production, a critical concern for contract manufacturing organizations (CMOs). The compound's crystallinity (melting point 78-81°C) facilitates purification, meeting stringent ICH Q3D elemental impurity requirements for pharmaceutical intermediates.

Market intelligence indicates rising demand for custom fluorination services utilizing this aldehyde, particularly in Asia-Pacific regions. Patent analysis shows a 40% increase in filings referencing difluorobenzaldehyde derivatives since 2020, driven by their utility in proteolysis-targeting chimeras (PROTACs) – a trending topic in drug discovery circles. Storage recommendations (2-8°C under nitrogen) and compatibility with continuous flow chemistry systems make it suitable for modern Industry 4.0 manufacturing setups.

Ongoing research explores its use in metal-organic frameworks (MOFs) for gas storage applications, capitalizing on the aldehyde group's coordinative properties. The compound's Hansen solubility parameters (δD=18.5, δP=6.2, δH=4.8 MPa^1/2) enable precise solvent selection for nanoparticle coating processes, addressing formulation challenges in advanced material science. These multifaceted applications position CAS 167684-02-8 as a versatile tool for interdisciplinary innovation.

Quality assurance protocols for 6-Ethoxy-2,3-difluorobenzaldehyde emphasize residual solvent monitoring by GC-MS and chiral purity verification via HPLC (Chiralpak AD-H column), reflecting industry's focus on quality-by-design principles. Its stability under photolytic stress (ICH Q1B compliant testing) makes it suitable for light-sensitive formulations, while the Structure-Activity Relationship (SAR) studies benefit from computational chemistry approaches using Gaussian 16 software.

Emerging applications include its use as a precursor for bioorthogonal chemistry probes, particularly in developing PET radiopharmaceuticals – a rapidly growing market segment. The compound's vapor pressure (0.12 mmHg at 25°C) and logP (2.1) values optimize its performance in high-throughput screening assays, meeting pharmaceutical industry needs for fragment-based drug discovery platforms. These attributes explain its inclusion in major building block catalogues from leading chemical suppliers.

• 146137-74-8(2-Fluoro-6-methoxybenzaldehyde)
• 214492-73-6(2-Fluoro-4,6-dimethoxybenzaldehyde)
• 947279-31-4(2,3-Difluoro-6-phenylmethoxybenzaldehyde)
• 902836-68-4(2-Fluoro-6-phenoxybenzaldehyde)
• 1431329-81-5(6-Ethoxy-2,3-difluorobenzoic acid)
• 1706430-72-9(2,3-Difluoro-5-methoxy-4-methylbenzaldehyde)
• 187543-87-9(2,3-Difluoro-6-methoxybenzaldehyde)
• 82129-45-1(BENZALDEHYDE, 2-ETHOXY-6-FLUORO-)
• 139008-21-2(Benzaldehyde, 4-fluoro-2-methoxy-5-methyl-)
• 608515-57-7(2,4-difluoro-6-methoxybenzaldehyde)