Cas no 166744-78-1 (4-Benzyloxy-2-fluorophenylboronic acid)
4-Benzyloxy-2-fluorophenylboronic acid is a versatile boronic acid derivative widely used in Suzuki-Miyaura cross-coupling reactions, a key method for forming carbon-carbon bonds in organic synthesis. The benzyloxy group at the 4-position enhances solubility in organic solvents, while the fluorine atom at the 2-position introduces electronic effects that can influence reactivity and regioselectivity. This compound is particularly valuable in pharmaceutical and materials science research due to its stability and compatibility with diverse reaction conditions. Its boronic acid moiety allows for efficient transmetalation with palladium catalysts, enabling the synthesis of complex biaryl structures. The product is typically supplied as a white to off-white crystalline solid with high purity, ensuring reliable performance in demanding synthetic applications.
166744-78-1 structure
Product Name:4-Benzyloxy-2-fluorophenylboronic acid
CAS No:166744-78-1
MF:C13H12BFO3
MW:246.041987419128
MDL:MFCD02093064
CID:65758
PubChem ID:2737786
Update Time:2025-07-02
4-Benzyloxy-2-fluorophenylboronic acid Chemical and Physical Properties
Names and Identifiers
-
- 4-Benzyloxy-2-fluorophenylboronic acid
- 4-Benzyloxy-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- 4-(Benzyloxy)-2-fluorophenylboronic acid
- (4-(Benzyloxy)-2-fluorophenyl)boronic acid
- (2-fluoro-4-phenylmethoxyphenyl)boronic acid
- 4-Benzyloxy-2-Fluorobenzeneboronic Acid
- 4-Benzyloxy-2-fluorobenzeneboronic Acid (contains varying amounts of Anhydride)
- AKOS BRN-0077
- 4-Benzyloxy-2-fluorophenylboro
- 166744-78-1
- 4-Benzyloxy-2-fluorobenzeneboronicacid97%
- 4-Benzyloxy-2-fluorobenzeneboronic acid 97%
- 4-(Benzyloxy)-2-fluorophenylboronic acid, 97%, anhydride present
- 4-(Benzyloxy)-2-fluorophenylboronic acid, May contain varying amounts of anhydride, 97%
- Boronic acid, [2-fluoro-4-(phenylmethoxy)phenyl]-
- PubChem7760
- KSC489M1H
- Boronic acid, B-[2-fluoro-4-(phenylmethox
- Boronic acid, B-[2-fluoro-4-(phenylmethoxy)phenyl]-
- PS-9564
- (4-benzyloxy-2-fluoro-phenyl)boronic acid
- AC-30999
- B4638
- MFCD02093064
- PQWKGFALWCOVTC-UHFFFAOYSA-N
- J-514496
- [4-(benzyloxy)-2-fluorophenyl]boronic acid
- DTXSID70372241
- EN300-832856
- 4-(benzyloxy)-2-fluorophenylboronic acid, AldrichCPR
- CS-W012704
- A810766
- SY034274
- 2-fluoro-4-benzyloxyphenylboronic acid
- 4-(benzoxy)-2-fluorophenylboronic acid
- AB10746
- 4-Benzyloxy-2-fluorophenylboronicacid
- (4-benzyloxy-2-fluoro-phenyl)boronic acid;4-(Benzyloxy)-2-fluorophenylboronic Acid
- AKOS004113766
- Z1258926902
- SCHEMBL1711426
- FT-0617649
- 4-benzyloxy-2-fluoro-phenylboronic acid
- DB-010649
-
- MDL： MFCD02093064
- Inchi： 1S/C13H12BFO3/c15-13-8-11(6-7-12(13)14(16)17)18-9-10-4-2-1-3-5-10/h1-8,16-17H,9H2
- InChI Key： PQWKGFALWCOVTC-UHFFFAOYSA-N
- SMILES： FC1C=C(C=CC=1B(O)O)OCC1C=CC=CC=1
Computed Properties
- Exact Mass: 246.08600
- Monoisotopic Mass: 246.086
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 18
- Rotatable Bond Count: 4
- Complexity: 246
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: nothing
- Topological Polar Surface Area: 49.7
Experimental Properties
- Color/Form: White solid
- Density: 1.2600
- Melting Point: 151 °C
- Boiling Point: 406.8℃/760mmHg
- Flash Point: 199.8 oC
- Refractive Index: 1.577
- Solubility: Soluble in methanol
- PSA: 49.69000
- LogP: 1.08450
- Solubility: Insoluble in water
- pka: 8.50±0.58(Predicted)
4-Benzyloxy-2-fluorophenylboronic acid Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Warning
- Hazard Statement： H315,H319,H335
- Warning Statement： P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
- Hazard Category Code： 36/37/38
- Safety Instruction： S26-S36/37/39
-
Hazardous Material Identification：
- Safety Term：S26;S36
- Risk Phrases：R36/37/38
- HazardClass：IRRITANT, KEEP COLD
- Storage Condition：Keep cold
4-Benzyloxy-2-fluorophenylboronic acid Customs Data
- HS CODE：2931900090
- Customs Data：
China Customs Code:
2931900090Overview:
2931900090. Other organic-Inorganic compound. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:AB(Customs clearance form for Inbound Goods,Customs clearance form for outbound goods). MFN tariff:6.5%. general tariff:30.0%
Summary:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%
4-Benzyloxy-2-fluorophenylboronic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBEB0366-1 G |
4-benzyloxy-2-fluorophenylboronic acid |
166744-78-1 | 95% | 1g |
￥ 363.00 | 2021-05-07 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBEB0366-5 G |
4-benzyloxy-2-fluorophenylboronic acid |
166744-78-1 | 95% | 5g |
￥ 1,089.00 | 2021-05-07 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBEB0366-10 G |
4-benzyloxy-2-fluorophenylboronic acid |
166744-78-1 | 95% | 10g |
￥ 1,815.00 | 2021-05-07 | |
| Alichem | A019113155-5g |
(4-(Benzyloxy)-2-fluorophenyl)boronic acid |
166744-78-1 | 96% | 5g |
208.00 USD | 2021-06-17 | |
| Alichem | A019113155-10g |
(4-(Benzyloxy)-2-fluorophenyl)boronic acid |
166744-78-1 | 96% | 10g |
291.50 USD | 2021-06-17 | |
| Alichem | A019113155-25g |
(4-(Benzyloxy)-2-fluorophenyl)boronic acid |
166744-78-1 | 96% | 25g |
686.00 USD | 2021-06-17 | |
| Fluorochem | 016103-250mg |
4-Benzyloxy-2-fluorophenylboronic acid |
166744-78-1 | 96% | 250mg |
￡14.00 | 2022-02-28 | |
| Fluorochem | 016103-10g |
4-Benzyloxy-2-fluorophenylboronic acid |
166744-78-1 | 96% | 10g |
￡218.00 | 2022-02-28 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | B102149-1g |
4-Benzyloxy-2-fluorophenylboronic acid |
166744-78-1 | 96% | 1g |
￥229.90 | 2023-09-04 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | B102149-200mg |
4-Benzyloxy-2-fluorophenylboronic acid |
166744-78-1 | 96% | 200mg |
￥70.90 | 2023-09-04 |
4-Benzyloxy-2-fluorophenylboronic acid Related Literature
-
Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
-
Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
-
Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
-
Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
166744-78-1 (4-Benzyloxy-2-fluorophenylboronic acid) Related Products
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- 871125-82-5((4-((4-Fluorobenzyl)oxy)phenyl)boronic acid)
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