• 1. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 2. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 4. An apparatus for testing water by measurement of its electrical conductivity
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• 5. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aniline and substituted anilines

2-Chloro-5-Iodoaniline: A Comprehensive Overview

2-Chloro-5-Iodoaniline, also known by its CAS registry number CAS No. 16604-98-1, is a significant compound in the field of organic chemistry. This compound has garnered attention due to its unique properties and potential applications in various industries. In this article, we will delve into the structural characteristics, chemical properties, synthesis methods, and recent advancements in its applications.

The molecular structure of 2-Chloro-5-Iodoaniline consists of an aniline backbone with a chlorine atom at the second position and an iodine atom at the fifth position. This substitution pattern imparts distinct electronic and steric properties to the molecule, making it versatile for different chemical reactions. Recent studies have highlighted its role as an intermediate in the synthesis of complex aromatic compounds, particularly in the pharmaceutical and agrochemical sectors.

One of the most notable aspects of 2-Chloro-5-Iodoaniline is its reactivity under various conditions. Research conducted in 2023 has shown that this compound can undergo nucleophilic aromatic substitution efficiently when activated by appropriate directing groups. This property has been exploited in the development of novel drug delivery systems, where controlled release mechanisms are critical. Additionally, its ability to act as a precursor for bioactive molecules has positioned it as a key player in medicinal chemistry.

The synthesis of 2-Chloro-5-Iodoaniline typically involves multi-step processes, including chlorination and iodination reactions. Recent advancements have focused on optimizing these steps to enhance yield and reduce environmental impact. For instance, catalytic methods using transition metal catalysts have been reported to significantly improve reaction efficiency while minimizing by-products.

In terms of applications, 2-Chloro-5-Iodoaniline has found utility in the production of advanced materials such as conductive polymers and high-performance composites. Its role as a building block for these materials is supported by its ability to form stable covalent bonds under thermal or photochemical conditions. Furthermore, ongoing research is exploring its potential in energy storage technologies, where its electronic properties could contribute to more efficient battery systems.

Safety considerations are paramount when handling 2-Chloro-5-Iodoaniline. While it is not classified as a hazardous material under standard conditions, proper precautions should be taken to avoid exposure during synthesis and handling. Recent guidelines emphasize the importance of using personal protective equipment and ensuring adequate ventilation in laboratory settings.

In conclusion, 2-Chloro-5-Iodoaniline, with its CAS number CAS No. 16604-98-1, continues to be a focal point in chemical research due to its unique properties and diverse applications. As new discoveries emerge, this compound is expected to play an even more pivotal role in advancing various scientific fields.

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