• 1. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 2. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 3. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 4. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 5. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Toluenes Nitrotoluenes
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Professional Introduction to 3,5-Dinitro-4-methylbenzoic Acid (CAS No: 16533-71-4)

3,5-Dinitro-4-methylbenzoic acid, with the chemical formula C?H?NO?, is a significant compound in the field of organic chemistry and pharmaceutical research. Its unique structural properties, characterized by the presence of nitro and carboxylic acid functional groups, make it a valuable intermediate in the synthesis of various bioactive molecules. This introduction delves into the compound's chemical properties, synthetic pathways, and its emerging applications in medicinal chemistry and material science.

The molecular structure of 3,5-Dinitro-4-methylbenzoic acid consists of a benzene ring substituted with a methyl group at the 4-position and nitro groups at the 3- and 5-positions. This arrangement imparts distinct reactivity and electronic characteristics to the molecule. The nitro groups are electron-withdrawing, which influences the molecule's acidity and its interaction with other functional groups. The carboxylic acid moiety further enhances its utility as a synthetic precursor, allowing for various transformations such as esterification, amidation, and reduction.

In recent years, 3,5-Dinitro-4-methylbenzoic acid has garnered attention in the development of pharmaceutical agents due to its potential as a building block for more complex molecules. Researchers have explored its role in synthesizing heterocyclic compounds, which are known for their broad spectrum of biological activities. For instance, derivatives of this compound have been investigated for their antimicrobial and anti-inflammatory properties. The nitro groups can be selectively reduced to amino groups, enabling the introduction of amine functionalities that are crucial in drug design.

The synthesis of 3,5-Dinitro-4-methylbenzoic acid typically involves nitration of methylbenzoic acid precursors. Advanced synthetic techniques have refined this process to achieve higher yields and purity. Modern methods often employ catalytic processes or green chemistry principles to minimize waste and energy consumption. The compound's stability under various conditions makes it suitable for large-scale production without significant degradation.

One of the most compelling aspects of 3,5-Dinitro-4-methylbenzoic acid is its versatility in medicinal chemistry applications. It serves as a key intermediate in the preparation of drugs targeting neurological disorders. For example, researchers have utilized this compound to develop novel compounds with potential neuroprotective effects. The ability to modify its structure allows chemists to fine-tune biological activity, making it a valuable tool in drug discovery pipelines.

The compound's role extends beyond pharmaceuticals into material science. Its aromatic structure and functional groups make it suitable for applications in organic electronics and polymer chemistry. In these fields, derivatives of 3,5-Dinitro-4-methylbenzoic acid have been used to create materials with specific electronic properties. These materials are essential in developing advanced technologies such as organic light-emitting diodes (OLEDs) and conductive polymers.

The latest research highlights several innovative uses of 3,5-Dinitro-4-methylbenzoic acid. A notable study demonstrated its application in catalysis, where it acts as a ligand in transition metal-catalyzed reactions. This finding opens new avenues for developing more efficient synthetic routes for complex molecules. Additionally, studies have explored its potential in environmental science, where it aids in the degradation of persistent organic pollutants through photochemical processes.

The future prospects for 3,5-Dinitro-4-methylbenzoic acid are promising, with ongoing research uncovering new applications and synthetic methodologies. As our understanding of molecular interactions deepens, so does the potential for this compound to contribute to advancements in medicine and materials science. Collaborative efforts between chemists, biologists, and engineers will likely drive further innovation.

In conclusion, 3,5-Dinitro-4-methylbenzoic acid (CAS No: 16533-71-4) is a multifaceted compound with significant implications across multiple scientific disciplines. Its unique structural features and reactivity make it an indispensable tool in pharmaceutical research and material development. As new methodologies emerge and our understanding evolves，this compound will continue to play a pivotal role in scientific advancements.

• 3113-71-1(3-Methyl-4-nitrobenzoic acid)
• 610-36-6(4-Amino-2-nitrobenzoic acid)
• 140380-55-8(2-Amino-4,6-dinitrobenzoic acid)
• 114168-48-8(Benzoic acid,4-amino-2,6-dinitro-)
• 96-98-0(4-Methyl-3-nitrobenzoic acid)
• 610-29-7(2-nitrobenzene-1,4-dicarboxylic acid)
• 28169-46-2(3,5-Dinitro-o-toluic Acid)
• 50573-74-5(2-Amino-6-nitrobenzoic acid)
• 1975-50-4(2-Methyl-3-nitrobenzoic acid)
• 3095-38-3(3,5-Dimethyl-4-nitrobenzoic acid)