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Comprehensive Overview of 4-Amino-2-(ethylthio)-5-pyrimidinecarbonitrile (CAS No. 16462-29-6)

4-Amino-2-(ethylthio)-5-pyrimidinecarbonitrile (CAS No. 16462-29-6) is a specialized pyrimidine derivative with significant applications in pharmaceutical and agrochemical research. This compound, characterized by its unique amino and ethylthio functional groups, has garnered attention for its potential role in drug discovery and material science. Researchers are increasingly exploring its synthetic pathways and biological activity, particularly in the context of heterocyclic chemistry and small-molecule inhibitors.

The molecular structure of 4-Amino-2-(ethylthio)-5-pyrimidinecarbonitrile features a pyrimidine core substituted with a cyano group at the 5-position and an ethylthio moiety at the 2-position. This configuration contributes to its reactivity and versatility in organic synthesis. Recent studies highlight its utility as a building block for more complex molecules, especially in the development of kinase inhibitors and antimicrobial agents. The compound’s solubility and stability under various conditions make it a valuable candidate for high-throughput screening.

In the context of current trends, 4-Amino-2-(ethylthio)-5-pyrimidinecarbonitrile aligns with the growing demand for sustainable chemistry and green synthesis methods. Researchers are investigating eco-friendly catalytic systems to optimize its production, addressing concerns about waste reduction and energy efficiency. Additionally, its potential applications in cancer therapeutics and neurodegenerative disease research have sparked interest, as evidenced by rising searches for "pyrimidine-based drug candidates" and "nitrile-containing bioactive compounds."

From an industrial perspective, CAS No. 16462-29-6 is often discussed in forums focusing on custom synthesis and scalable manufacturing. Companies specializing in fine chemicals emphasize its role in intermediate production, particularly for APIs (Active Pharmaceutical Ingredients). The compound’s purity standards and analytical characterization (e.g., HPLC, NMR) are critical topics for quality control professionals, reflecting its importance in regulatory compliance.

Emerging technologies like AI-driven molecular design and computational chemistry are also shaping the future of 4-Amino-2-(ethylthio)-5-pyrimidinecarbonitrile research. Predictive modeling tools are being used to explore its structure-activity relationships (SAR), accelerating the discovery of novel analogs. This aligns with frequent user queries such as "how to modify pyrimidine scaffolds for enhanced bioactivity" and "best practices for nitrile group functionalization."

In summary, 4-Amino-2-(ethylthio)-5-pyrimidinecarbonitrile represents a multifaceted compound with broad scientific relevance. Its integration into cutting-edge research and industrial workflows underscores its value as a key intermediate in modern chemistry. As innovation continues, this compound is poised to play a pivotal role in advancing precision medicine and sustainable chemical processes.

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• 770-30-9(4-amino-2-(methylsulfanyl)pyrimidine-5-carbonitrile)
• 185040-27-1(4-(Methylamino)-2-(methylthio)pyrimidine-5-carbonitrile)
• 54410-87-6(4-Pyrimidinamine, 2-(ethylthio)-5-methyl-)
• 664994-02-9(4-amino-2-(prop-2-en-1-ylsulfanyl)pyrimidine-5-carbonitrile)
• 933949-26-9(4-Amino-2-(propylthio)-5-pyrimidinecarbonitrile)
• 500341-46-8(2-(4-Amino-5-cyanopyrimidin-2-yl)sulfanylacetic acid)
• 149034-23-1(4-amino-2-[2-(4-amino-5-cyanopyrimidin-2-yl)disulfanyl]-pyrimidine-5-carbonitrile)
• 54308-64-4(5-methyl-2-(methylsulfanyl)pyrimidin-4-amine)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)