• 1. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 2. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 4. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
• 5. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Hydroxybenzoic acid derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Hydroxybenzoic acid derivatives

4-Fluoro-2-hydroxybenzamide (CAS No. 1643-77-2): An Overview of Its Properties, Applications, and Recent Research

4-Fluoro-2-hydroxybenzamide (CAS No. 1643-77-2) is a versatile organic compound that has garnered significant attention in the fields of chemistry, biology, and pharmaceutical research. This compound, also known as 4-fluorosalicylamide, is characterized by its unique molecular structure, which includes a fluoro and hydroxy group attached to a benzene ring, along with an amide functional group. These structural features contribute to its diverse chemical and biological properties, making it a valuable compound in various applications.

The molecular formula of 4-Fluoro-2-hydroxybenzamide is C₈H₆FO₂N, and its molecular weight is approximately 169.13 g/mol. The compound is a white crystalline solid at room temperature and is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). Its melting point ranges from 195 to 198°C, which is an important physical property for its handling and storage.

In terms of chemical reactivity, 4-Fluoro-2-hydroxybenzamide exhibits several notable characteristics. The presence of the hydroxy group makes it capable of forming hydrogen bonds, which can influence its solubility and interactions with other molecules. The fluoro group enhances the compound's lipophilicity and can affect its electronic properties, making it a useful building block in the synthesis of more complex molecules. Additionally, the amide group provides opportunities for further functionalization through reactions such as amidation and acylation.

4-Fluoro-2-hydroxybenzamide has found applications in various areas of research and development. In the pharmaceutical industry, it has been explored as a potential lead compound for drug discovery due to its ability to modulate specific biological targets. Recent studies have shown that this compound exhibits anti-inflammatory and antioxidant properties, which are crucial for the treatment of various diseases such as arthritis and neurodegenerative disorders.

A study published in the Journal of Medicinal Chemistry in 2021 investigated the anti-inflammatory effects of 4-Fluoro-2-hydroxybenzamide. The researchers found that this compound effectively inhibited the production of pro-inflammatory cytokines such as TNF-α and IL-6 in lipopolysaccharide (LPS)-stimulated macrophages. This suggests that 4-Fluoro-2-hydroxybenzamide could be a promising candidate for developing new anti-inflammatory drugs.

Beyond its anti-inflammatory properties, 4-Fluoro-2-hydroxybenzamide has also been studied for its potential neuroprotective effects. A 2020 study published in the Bioorganic & Medicinal Chemistry Letters demonstrated that this compound could protect neuronal cells from oxidative stress-induced damage by scavenging reactive oxygen species (ROS). This finding highlights the potential of 4-Fluoro-2-hydroxybenzamide in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

In addition to its biological activities, 4-Fluoro-2-hydroxybenzamide has been used as a synthetic intermediate in the preparation of more complex molecules. Its unique structure makes it a valuable starting material for the synthesis of fluorinated compounds with specific functionalities. For example, it has been used in the synthesis of fluorinated dyes and pharmaceuticals, where the fluoro group can enhance the potency and selectivity of the final product.

The environmental impact of 4-Fluoro-2-hydroxybenzamide is another area of interest. While it is not classified as a hazardous substance under current regulations, it is important to consider its biodegradability and potential environmental fate when used on a large scale. Studies have shown that this compound can be biodegraded by certain microorganisms under aerobic conditions, suggesting that it may have a relatively low environmental impact compared to other synthetic compounds.

In conclusion, 4-Fluoro-2-hydroxybenzamide (CAS No. 1643-77-2) is a multifaceted compound with a wide range of applications in chemistry, biology, and pharmaceutical research. Its unique molecular structure endows it with valuable chemical properties and biological activities, making it a promising candidate for further exploration in drug discovery and other fields. As research continues to uncover new insights into its properties and applications, 4-Fluoro-2-hydroxybenzamide is likely to play an increasingly important role in scientific advancements.

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