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Comprehensive Overview of 1-(2-Bromopyridin-3-yl)-1-phenylethan-1-ol (CAS No. 1642544-74-8)

1-(2-Bromopyridin-3-yl)-1-phenylethan-1-ol (CAS No. 1642544-74-8) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its unique bromopyridine and phenylethan-1-ol moieties, serves as a critical intermediate in the synthesis of various bioactive molecules. Its molecular structure, which combines a 2-bromopyridine ring with a phenyl-ethanol group, offers versatile reactivity, making it valuable for cross-coupling reactions and chiral synthesis.

In recent years, the demand for 1-(2-Bromopyridin-3-yl)-1-phenylethan-1-ol has surged due to its applications in drug discovery and material science. Researchers are particularly interested in its role as a building block for heterocyclic compounds, which are pivotal in developing kinase inhibitors and antiviral agents. The compound's bromine substituent facilitates further functionalization, enabling the creation of complex molecular architectures. This aligns with the growing trend of fragment-based drug design, where small molecules like this are used to optimize lead compounds.

From an industrial perspective, CAS No. 1642544-74-8 is synthesized through controlled Grignard reactions or palladium-catalyzed couplings, ensuring high purity and yield. Its stability under standard conditions makes it suitable for large-scale production. Environmental and safety considerations are also addressed, as modern synthetic protocols emphasize green chemistry principles, such as reducing solvent waste and using catalytic methods. This resonates with the global push toward sustainable chemical manufacturing, a topic frequently searched by professionals in the field.

The compound's relevance extends to academic research, where it is employed to study structure-activity relationships (SAR) and molecular recognition. Its chiral center at the ethanol moiety opens avenues for enantioselective synthesis, a hot topic in asymmetric catalysis. Questions like "How to optimize chiral purity in 1-(2-Bromopyridin-3-yl)-1-phenylethan-1-ol derivatives?" are commonly explored in forums and publications, reflecting its practical challenges.

Analytical techniques such as HPLC, NMR, and mass spectrometry are routinely used to characterize 1-(2-Bromopyridin-3-yl)-1-phenylethan-1-ol, ensuring compliance with regulatory standards. The compound's spectral data and physicochemical properties are well-documented, aiding in its identification and quality control. This transparency supports its adoption in GMP-compliant processes, a key concern for pharmaceutical manufacturers.

In summary, 1-(2-Bromopyridin-3-yl)-1-phenylethan-1-ol (CAS No. 1642544-74-8) stands out as a multifaceted compound with broad applications. Its integration into drug development pipelines and material innovation underscores its importance. As research continues to uncover new uses, this compound will likely remain a focal point in organic synthesis and industrial chemistry.

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