• 1. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 2. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 3. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 4. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 5. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Secondary alcohols
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alcohols and polyols Secondary alcohols

(2R)-4-Methylpentan-2-ol (CAS No. 16404-54-9): An Overview of Its Properties, Applications, and Recent Research

(2R)-4-Methylpentan-2-ol (CAS No. 16404-54-9) is a chiral alcohol that has garnered significant attention in the fields of organic chemistry, pharmaceuticals, and materials science due to its unique properties and potential applications. This compound, also known as (R)-3-methylbutan-2-ol, is a member of the branched-chain alcohols and is characterized by its chiral center, which imparts enantiomeric specificity to its structure and reactivity.

The chemical structure of (2R)-4-methylpentan-2-ol consists of a five-carbon chain with a methyl group attached to the fourth carbon and a hydroxyl group attached to the second carbon. The presence of the chiral center at the second carbon position results in two enantiomers: (R)- and (S)-forms. The (R)-enantiomer, specifically, has been the focus of numerous studies due to its potential in asymmetric synthesis and its biological activity.

In terms of physical properties, (2R)-4-methylpentan-2-ol is a colorless liquid with a characteristic odor. It is soluble in water and many organic solvents, making it versatile for various applications. The compound has a boiling point of approximately 138°C and a melting point of -83°C. Its density is around 0.83 g/cm3 at room temperature.

One of the key areas where (2R)-4-methylpentan-2-ol has shown promise is in pharmaceutical research. Chiral alcohols are essential building blocks in the synthesis of many drugs due to their ability to influence the stereochemistry of target molecules. For instance, recent studies have explored the use of (2R)-4-methylpentan-2-ol as an intermediate in the synthesis of chiral drugs with improved efficacy and reduced side effects. The enantiomeric purity of this compound is crucial for ensuring the desired pharmacological properties.

In addition to its role in drug synthesis, (2R)-4-methylpentan-2-ol has been investigated for its potential as a fragrance component. Its unique odor profile makes it suitable for use in perfumes and other fragrance formulations. The compound's volatility and solubility properties contribute to its effectiveness in these applications.

Recent advancements in asymmetric catalysis have further expanded the utility of (2R)-4-methylpentan-2-ol. Researchers have developed novel catalysts that can efficiently produce this chiral alcohol with high enantiomeric excess (ee). These catalysts often involve transition metals such as ruthenium or iridium, which facilitate stereoselective hydrogenation reactions. The ability to produce large quantities of enantiomerically pure (2R)-4-methylpentan-2-ol at an industrial scale has significant implications for both academic research and commercial applications.

The biological activity of (2R)-4-methylpentan-2-ol has also been a subject of interest. Studies have shown that this compound can exhibit antimicrobial properties, particularly against certain bacteria and fungi. This property makes it a potential candidate for developing new antimicrobial agents or additives in consumer products such as soaps and detergents.

In the field of materials science, (2R)-4-methylpentan-2-ol has been explored as a solvent or modifier in polymer synthesis and processing. Its ability to dissolve various polymers while maintaining good solubility parameters makes it useful in creating tailored polymer blends with specific mechanical or thermal properties. Additionally, the compound's low toxicity profile enhances its suitability for use in materials that come into contact with humans or the environment.

To summarize, (2R)-4-methylpentan-2-ol (CAS No. 16404-54-9) is a versatile chiral alcohol with a wide range of applications in pharmaceuticals, fragrances, catalysis, and materials science. Its unique chemical structure and properties make it an important molecule for both academic research and industrial processes. Ongoing research continues to uncover new uses and optimize existing applications, further solidifying its significance in multiple scientific disciplines.

• 119947-03-4(1,8-Pentadecanediol, 14-methyl-)
• 25564-57-2(4-Decanol, 2-methyl-)
• 26981-98-6(7-Methylnonan-4-ol)
• 40225-75-0(6-Methyloctan-3-ol)
• 62718-02-9(1,5-HEXANEDIOL, 3-METHYL-, (R*,S*)-)
• 174173-57-0
• 726186-25-0(1,5-NONANEDIOL, 3-METHYL-)
• 765304-24-3(2-DECANOL, 7-METHYL-)
• 66576-29-2(2-HEXANOL, 4,5-DIMETHYL-)
• 66576-33-8(4-ethylhexan-2-ol)