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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Quaternary ammonium salts

Comprehensive Overview of (1S,2S)-2-fluorocyclopropan-1-amine hydrochloride (CAS No. 1638744-20-3)

The compound (1S,2S)-2-fluorocyclopropan-1-amine hydrochloride (CAS No. 1638744-20-3) is a chiral fluorinated cyclopropane derivative with significant potential in pharmaceutical and agrochemical applications. Its unique structural features, including the fluorine substitution and the cyclopropane ring, make it a valuable intermediate in the synthesis of bioactive molecules. Researchers and industry professionals are increasingly interested in this compound due to its role in drug discovery and development, particularly in the design of enzyme inhibitors and receptor modulators.

One of the most searched questions related to (1S,2S)-2-fluorocyclopropan-1-amine hydrochloride is its synthetic route and stereoselective preparation. The compound's stereochemistry is critical for its biological activity, and methods to achieve high enantiomeric purity are a hot topic in organic chemistry. Recent advancements in asymmetric synthesis, such as chiral auxiliary-assisted reactions or catalytic enantioselective fluorination, have been explored to produce this compound efficiently. These techniques align with the growing demand for green chemistry and sustainable synthetic practices.

Another area of interest is the pharmacological applications of (1S,2S)-2-fluorocyclopropan-1-amine hydrochloride. Fluorinated compounds are known for their enhanced metabolic stability and bioavailability, making them attractive candidates for drug development. This compound, in particular, has been investigated for its potential in central nervous system (CNS) therapeutics, owing to the ability of fluorine to influence blood-brain barrier penetration. Researchers are also exploring its use in proteolysis-targeting chimeras (PROTACs), a cutting-edge technology in targeted protein degradation.

The physical and chemical properties of (1S,2S)-2-fluorocyclopropan-1-amine hydrochloride are frequently queried in scientific databases. The compound typically appears as a white to off-white crystalline powder, soluble in polar solvents like water and methanol. Its stability under various conditions (e.g., pH, temperature) is crucial for storage and handling, which is a common concern for laboratory technicians and process chemists. Analytical methods such as HPLC, NMR, and mass spectrometry are routinely employed to characterize and quantify this compound.

In the context of market trends, the demand for fluorinated building blocks like (1S,2S)-2-fluorocyclopropan-1-amine hydrochloride is rising, driven by the expanding pharmaceutical and agrochemical sectors. Companies specializing in custom synthesis and contract research are actively offering this compound to support drug discovery programs. Additionally, the compound's relevance in bioconjugation and click chemistry applications has garnered attention, as these techniques are widely used in biopharmaceutical development and diagnostics.

Safety and regulatory aspects are also a focus for users researching (1S,2S)-2-fluorocyclopropan-1-amine hydrochloride. While the compound is not classified as hazardous under standard regulations, proper laboratory practices, including the use of personal protective equipment (PPE) and adequate ventilation, are recommended. Regulatory compliance, such as REACH and GMP standards, is essential for its use in commercial applications, particularly in the pharmaceutical industry.

In summary, (1S,2S)-2-fluorocyclopropan-1-amine hydrochloride (CAS No. 1638744-20-3) is a versatile and valuable compound with broad applications in medicinal chemistry and beyond. Its synthesis, properties, and potential uses continue to be areas of active research, reflecting the compound's importance in modern science. As the field of fluorinated compounds evolves, this molecule is likely to remain a key player in innovative therapeutic and agrochemical solutions.

• 114152-96-4(trans-2-fluorocyclopropanamine;hydrochloride)
• 105919-28-6(cis-2-Fluorocyclopropaneamine)
• 105919-31-1(Cyclopropanamine, 2-fluoro-)
• 1086372-16-8((1R,2S)-2-Fluorocyclopropanamine)
• 143062-74-2(Cyclopropanamine, 2-fluoro-, hydrochloride, trans-(±)-)
• 105614-25-3(2,2-difluorocyclopropan-1-amine hydrochloride)
• 141042-21-9((1R,2S)-2-fluorocyclopropan-1-amine hydrochloride)
• 143062-83-3((1R,2S)-2-fluorocyclopropan-1-amine)
• 143062-71-9(Cyclopropanamine, 2-fluoro-, hydrochloride, cis-(±)-)
• 114152-95-3(cis-2-fluorocyclopropanamine;hydrochloride)