Cas no 16339-07-4 (N-Methyl-N’-nitrosopiperazine)

N-Methyl-N’-nitrosopiperazine (MNP) is a nitrosamine compound primarily used in research and industrial applications, particularly in the study of nitrosamine chemistry and carcinogenicity. Its well-defined structure and reactivity make it a valuable reference standard for analytical methods, such as HPLC and GC-MS, in detecting and quantifying nitrosamine impurities in pharmaceuticals and other products. MNP’s stability under controlled conditions ensures reliable performance in laboratory settings. Due to its potential hazards, proper handling and storage are essential. Researchers utilize MNP to investigate nitrosamine formation mechanisms, contributing to improved safety protocols in chemical synthesis and quality control processes.
N-Methyl-N’-nitrosopiperazine structure
N-Methyl-N’-nitrosopiperazine structure
Product Name:N-Methyl-N’-nitrosopiperazine
CAS No:16339-07-4
MF:C5H11N3O
MW:129.160340547562
MDL:MFCD01702457
CID:150885
PubChem ID:27826
Update Time:2025-09-18

N-Methyl-N’-nitrosopiperazine Chemical and Physical Properties

Names and Identifiers

    • Piperazine,1-methyl-4-nitroso-
    • (6AR)-TERT-BUTYL 6A-PHENYL-HEXAHYDROPYRROLO[3,4-C]PYRROLE-2(1H)-CARBOXYLATE
    • 1-METHYL-4-NITROSOPIPERAZINE
    • N-Methyl-N’-nitrosopiperazine
    • 1-methyl-4-nitroso-piperazine
    • 1-Nitroso-4-methylpiperazine
    • Methylnitrosopiperidine
    • Methylpiperazinenitrosamine
    • N-Methylnitrosopiperazine
    • N-Methyl-npz
    • N-Nitrosomethylpiperazine
    • N-Nitroso-N'-methylpiperazin
    • N-Nitroso-N'-methylpiperazine
    • PIPERAZINE,1-METHYL-4-NITROSO
    • PIPERAZINE, 1-METHYL-4-NITROSO-
    • N'-Methyl-N-nitrosopiperazine
    • N-Nitroso-N'-methylpiperazin [German]
    • N-Methyl-N'-nitrosopiperazine
    • 5584MPJ7F2
    • NSC 523886
    • DTXSID30167574
    • NSC523886
    • NS00025333
    • CCRIS 1151
    • N-Methyl-N'-nitrosopiperazine (100mg/L in Methanol)
    • Q27261293
    • CHEMBL164193
    • WLN: T6N DNTJ ANO D1
    • EINECS 240-409-3
    • AS-60418
    • UNII-5584MPJ7F2
    • BRN 0117135
    • A937115
    • 5-23-03-00220 (Beilstein Handbook Reference)
    • EN300-25386041
    • NSC-523886
    • SCHEMBL11623926
    • Z1198157883
    • AKOS006276505
    • 16339-07-4
    • CEAIOKFZXJMDAS-UHFFFAOYSA-N
    • D92907
    • METHYL-4-NITROSOPIPERAZINE, 1-
    • 1-Methyl-4-nitrosopiperazine; 1-Nitroso-4-methylpiperazine; N-Nitroso-N'-methylpiperazine; NSC 523886;
    • DTXCID8090065
    • NNitrosomethylpiperazine
    • Piperazine, 1methyl4nitroso
    • N'MethylNnitrosopiperazine
    • NNitrosoN'methylpiperazin
    • 1Methyl4nitrosopiperazine
    • NMethylnitrosopiperazine
    • A1-88864
    • 1-Methyl-4-nitrosopiperazine; 1-Nitroso-4-methylpiperazine; N-Nitroso-N'-methylpiperazine; NSC 523886
    • NMethylnpz
    • 1Nitroso4methylpiperazine
    • MDL: MFCD01702457
    • Inchi: 1S/C5H11N3O/c1-7-2-4-8(6-9)5-3-7/h2-5H2,1H3
    • InChI Key: CEAIOKFZXJMDAS-UHFFFAOYSA-N
    • SMILES: O=NN1CCN(C)CC1
    • BRN: 0117135

Computed Properties

  • Exact Mass: 129.09000
  • Monoisotopic Mass: 129.09
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 9
  • Rotatable Bond Count: 0
  • Complexity: 98.4
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.2
  • Topological Polar Surface Area: 35.9

Experimental Properties

  • Density: 1.1508 (rough estimate)
  • Boiling Point: 239.23°C (rough estimate)
  • Flash Point: 97.1°C
  • Refractive Index: 1.5070 (estimate)
  • PSA: 35.91000
  • LogP: -0.20900

N-Methyl-N’-nitrosopiperazine Customs Data

  • HS CODE:2933599090
  • Customs Data:

    China Customs Code:

    2933599090

    Overview:

    2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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N-Methyl-N’-nitrosopiperazine Suppliers

Amadis Chemical Company Limited
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(CAS:16339-07-4)N-Methyl-N’-nitrosopiperazine
Order Number:A937115
Stock Status:in Stock
Quantity:5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 15:22
Price ($):326.0

N-Methyl-N’-nitrosopiperazine Related Literature

Additional information on N-Methyl-N’-nitrosopiperazine

Introduction to N-Methyl-N’-nitrosopiperazine (CAS No. 16339-07-4)

N-Methyl-N’-nitrosopiperazine, with the chemical formula C?H?N?O and a CAS number of 16339-07-4, is a significant compound in the field of chemical and pharmaceutical research. This compound has garnered considerable attention due to its unique structural properties and potential applications in various scientific domains. Understanding its characteristics, synthesis methods, and emerging research applications is essential for researchers and professionals in the industry.

The molecular structure of N-Methyl-N’-nitrosopiperazine consists of a piperazine ring substituted with a methyl group at one nitrogen atom and a nitroso group at the other. This arrangement imparts distinct reactivity and functionality, making it a valuable intermediate in organic synthesis. The nitroso group, in particular, is known for its ability to participate in various chemical transformations, which has opened up numerous possibilities for its use in drug development and material science.

In recent years, N-Methyl-N’-nitrosopiperazine has been studied extensively for its potential role in medicinal chemistry. Researchers have been exploring its derivatives as candidates for treating neurological disorders, cancer, and other diseases. The compound's ability to interact with biological targets has made it a focal point in the development of novel therapeutic agents. For instance, studies have shown that certain derivatives of this compound exhibit potent inhibitory effects on specific enzymes implicated in neurodegenerative diseases.

The synthesis of N-Methyl-N’-nitrosopiperazine is another area of active research. Traditional methods often involve the nitrosation of piperazine derivatives, but recent advancements have focused on more efficient and environmentally friendly approaches. Catalytic processes and green chemistry principles have been employed to optimize the synthesis, reducing waste and improving yields. These innovations are crucial for ensuring the sustainable production of this compound for industrial applications.

One of the most intriguing aspects of N-Methyl-N’-nitrosopiperazine is its role as a precursor in the synthesis of more complex molecules. Its structural framework allows for modifications that can lead to the development of new pharmacophores. Researchers have utilized this compound to create libraries of derivatives, which are then screened for biological activity. This approach has led to the discovery of several compounds with promising therapeutic properties.

The pharmacological properties of N-Methyl-N’-nitrosopiperazine have been investigated in various preclinical models. Studies have demonstrated its potential as an antitumor agent by interfering with key signaling pathways involved in cancer cell proliferation. Additionally, its interactions with neurotransmitter systems have suggested possible applications in treating conditions such as depression and anxiety. These findings underscore the importance of continued research into this compound's therapeutic potential.

Advances in computational chemistry have also played a significant role in understanding the behavior of N-Methyl-N’-nitrosopiperazine. Molecular modeling techniques allow researchers to predict how this compound interacts with biological targets at an atomic level. This information is invaluable for designing more effective derivatives with enhanced specificity and reduced side effects. The integration of computational methods with experimental approaches has accelerated the pace of discovery in this field.

The future prospects for N-Methyl-N’-nitrosopiperazine are promising, with ongoing research aiming to unlock its full potential. Collaborative efforts between academia and industry are essential for translating laboratory findings into clinical applications. As our understanding of this compound grows, so does the likelihood of developing novel treatments that could benefit patients worldwide.

In conclusion, N-Methyl-N’-nitrosopiperazine (CAS No. 16339-07-4) represents a fascinating compound with diverse applications in pharmaceuticals and chemical research. Its unique structure, reactivity, and potential therapeutic benefits make it a cornerstone in modern drug discovery efforts. Continued exploration into its properties and applications will undoubtedly lead to groundbreaking advancements in medicine and science.

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Amadis Chemical Company Limited
(CAS:16339-07-4)N-Methyl-N’-nitrosopiperazine
A937115
Purity:99%
Quantity:5g
Price ($):326.0
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