• 1. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 2. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 3. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 4. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acid methyl esters
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acid esters Fatty acid methyl esters

Comprehensive Overview of Methyl 3-(tert-Butoxycarbonylamino)butanoate (CAS No. 163254-35-1)

Methyl 3-(tert-Butoxycarbonylamino)butanoate (CAS No. 163254-35-1) is a specialized organic compound widely utilized in pharmaceutical synthesis, peptide chemistry, and advanced material research. This ester derivative, featuring a tert-butoxycarbonyl (Boc) protecting group, is highly valued for its stability and versatility in multi-step synthetic processes. Its molecular structure, combining a methyl ester and a Boc-protected amine, makes it a critical intermediate for constructing complex molecules, particularly in drug discovery and bioconjugation applications.

In recent years, the demand for Boc-protected amino acid derivatives like Methyl 3-(tert-Butoxycarbonylamino)butanoate has surged due to their role in developing peptide-based therapeutics and small-molecule inhibitors. Researchers frequently search for "Boc-protecting group applications" or "synthetic routes for amino acid esters," reflecting the compound's relevance in modern organic chemistry. Its compatibility with solid-phase peptide synthesis (SPPS) and mild deprotection conditions further enhances its appeal.

The compound's CAS No. 163254-35-1 is a key identifier in regulatory and commercial databases, ensuring precise tracking in supply chains. Analytical techniques such as HPLC, NMR, and mass spectrometry are routinely employed to verify its purity, a topic often queried in scientific forums. Environmental and safety considerations are also trending topics, with users seeking "green chemistry alternatives for Boc deprotection" or "handling guidelines for lab-scale use."

From an industrial perspective, Methyl 3-(tert-Butoxycarbonylamino)butanoate is synthesized via carbodiimide-mediated coupling or enzymatic esterification, methods frequently discussed in patent literature. Its stability under acidic conditions—unlike other protecting groups—makes it ideal for orthogonal synthesis strategies. This property aligns with the growing interest in "multi-component reactions" and "cascade catalysis," as highlighted in recent publications.

Emerging applications include its use in biodegradable polymers and drug-delivery systems, where the Boc group's controlled removal is advantageous. The compound's role in prodrug design is another hot topic, particularly for enhancing bioavailability of polar active pharmaceutical ingredients (APIs). Such innovations address frequent search queries like "improving drug solubility with ester prodrugs."

In summary, Methyl 3-(tert-Butoxycarbonylamino)butanoate (CAS No. 163254-35-1) exemplifies the intersection of synthetic efficiency and functional diversity. Its adaptability to high-throughput screening and automated synthesis platforms positions it as a staple in both academic and industrial settings, answering the demand for "scalable chiral building blocks"—a phrase increasingly prevalent in chemical procurement databases.

• 158851-30-0((3S)-3-(tert-butoxycarbonylamino)butanoic acid)
• 52815-19-7(Boc-dl-3-aminobutyric acid)
• 129765-95-3(3-{[(tert-butoxy)carbonyl]amino}-3-methylbutanoic acid)
• 132549-43-0(Boc-L-beta-Homoleucine)
• 749208-35-3(Boc-D-beta-Homoserine)
• 83345-44-2(Boc-HoSer-OH)
• 159991-23-8((R)-3-(tert-Butoxycarbonylamino)butanoic Acid)
• 215789-45-0(trans-2-4-(tert-Butoxycarbonyl)aminocyclohexylacetic Acid Methyl Ester)
• 159877-47-1(Methyl (R)-N-boc-3-aminobutyrate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)