Cas no 162635-03-2 (Temsirolimus Acetonide)

Temsirolimus Acetonide structure
Temsirolimus Acetonide structure
Product Name:Temsirolimus Acetonide
CAS No:162635-03-2
MF:C59H91NO16
MW:1070.35096001625
CID:824962
Update Time:2025-07-15

Temsirolimus Acetonide Chemical and Physical Properties

Names and Identifiers

    • Temsirolimus Acetonide
    • Temsirolimus Acetoni
    • Rapamycin 42-(2,2,5-Trimethyl-1,3-dioxane-5-carboxylate)
    • rapamycin 42-ester with 2,2,5-trimethyl[1,3]dioxane-5-carboxylic acid
    • Inchi： 1S/C59H91NO16/c1-35-19-15-14-16-20-36(2)47(69-11)31-43-24-22-41(7)59(68,76-43)53(64)54(65)60-26-18-17-21-44(60)55(66)74-48(32-45(61)37(3)28-40(6)51(63)52(71-13)50(62)39(5)27-35)38(4)29-42-23-25-46(49(30-42)70-12)75-56(67)58(10)33-72-57(8,9)73-34-58/h14-16,19-20,28,35,37-39,41-44,46-49,51-52,63,68H,17-18,21-27,29-34H2,1-13H3/t35-,37-,38-,39-,41-,42+,43+,44+,46-,47+,48+,49-,51-,52+,59-/m1/s1
    • InChI Key： YGGRYGCDSJUKRW-HXHLHDFISA-N
    • SMILES： O(C(C1(C)COC(C)(C)OC1)=O)[C@@H]1CC[C@@H](C[C@@H](C)[C@@H]2CC([C@@H](C=C(C)[C@H]([C@H](C([C@H](C)C[C@H](C)C=CC=CC=C(C)[C@H](C[C@@H]3CC[C@@H](C)[C@@](C(C(N4CCCC[C@H]4C(=O)O2)=O)=O)(O)O3)OC)=O)OC)O)C)=O)C[C@H]1OC

Computed Properties

  • Exact Mass: 1069.63000

Experimental Properties

  • Melting Point: 89-91°C
  • Refractive Index: 1.547
  • PSA: 219.96000
  • LogP: 7.45860

Temsirolimus Acetonide Security Information

  • Storage Condition：-20°C Freezer, Under Inert Atmosphere

Temsirolimus Acetonide Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
T017970-10mg
Temsirolimus Acetonide
 162635-03-2
10mg
 $ 161.00 2023-09-06
TRC
T017970-25mg
Temsirolimus Acetonide
 162635-03-2
25mg
 $ 305.00 2023-09-06
TRC
T017970-50mg
Temsirolimus Acetonide
 162635-03-2
50mg
 $ 597.00 2023-09-06
TRC
T017970-100mg
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 162635-03-2
100mg
 $1068.00 2023-05-17
SHENG KE LU SI SHENG WU JI SHU
sc-212997-1 mg
Temsirolimus Acetonide,
 162635-03-2
1mg
 ￥2,256.00 2023-07-10
SHENG KE LU SI SHENG WU JI SHU
sc-212997-1mg
Temsirolimus Acetonide,
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1mg
 ￥2256.00 2023-09-05
A2B Chem LLC
AE84164-1mg
Temsirolimus Acetonide
 162635-03-2
1mg
 $1125.00 2024-04-20
A2B Chem LLC
AE84164-5mg
Temsirolimus Acetonide
 162635-03-2
5mg
 $2400.00 2024-04-20

Temsirolimus Acetonide Production Method

Temsirolimus Acetonide Related Literature

Additional information on Temsirolimus Acetonide

Temsirolimus Acetonide: A Comprehensive Overview

Temsirolimus Acetonide, with the CAS number 162635-03-2, is a compound of significant interest in the fields of pharmacology and medicinal chemistry. This compound is a derivative of temsirolimus, which is a known immunosuppressive agent with potent antineoplastic properties. The acetonide form of temsirolimus is often used in research and development to enhance the stability and bioavailability of the parent compound, making it a valuable tool in preclinical studies and drug delivery systems.

The synthesis of Temsirolimus Acetonide involves a series of complex chemical reactions, including acetylation to stabilize the hydroxyl group present in the temsirolimus structure. This modification not only improves the physical properties of the compound but also facilitates its formulation into various drug delivery systems, such as nanoparticles or liposomes, which are currently being explored for targeted cancer therapy.

Recent studies have highlighted the potential of Temsirolimus Acetonide in enhancing the efficacy of cancer treatments. For instance, research published in 2023 demonstrated that this compound exhibits enhanced cytotoxicity against various cancer cell lines compared to its parent compound, temsirolimus. The acetonide modification was found to improve drug uptake and retention in cancer cells, leading to more effective tumor suppression.

In addition to its antineoplastic properties, Temsirolimus Acetonide has shown promise in modulating immune responses, making it a potential candidate for immunotherapy applications. Preclinical trials have indicated that this compound can suppress the proliferation of immune cells that contribute to autoimmune diseases, suggesting its potential use in treating conditions such as rheumatoid arthritis or multiple sclerosis.

The pharmacokinetic profile of Temsirolimus Acetonide has also been a focus of recent investigations. Studies have shown that the acetonide modification significantly improves the compound's solubility and bioavailability, which are critical factors for its therapeutic effectiveness. This advancement has paved the way for further exploration into its clinical applications, particularly in combination therapies for refractory cancers.

From a manufacturing standpoint, the production of Temsirolimus Acetonide requires stringent quality control measures to ensure consistency and purity. The synthesis process involves multiple steps, including purification techniques such as chromatography and crystallization, to isolate the compound in its purest form. These processes are essential for maintaining the integrity of the compound and ensuring its suitability for both research and therapeutic purposes.

In conclusion, Temsirolimus Acetonide (CAS No. 162635-03-2) represents a significant advancement in medicinal chemistry, offering improved stability, bioavailability, and therapeutic potential compared to its parent compound. With ongoing research uncovering new applications and mechanisms of action, this compound holds great promise for revolutionizing cancer treatment and immunotherapy approaches in the near future.

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