• 1. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 2. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 3. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 4. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 5. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylacetaldehydes

Comprehensive Overview of 2,2-Dihydroxy-1-(4-methylphenyl)ethan-1-one (CAS No. 16208-14-3)

2,2-Dihydroxy-1-(4-methylphenyl)ethan-1-one, with the CAS number 16208-14-3, is a specialized organic compound that has garnered significant attention in the fields of pharmaceuticals, cosmetics, and chemical synthesis. This compound, often referred to as a dihydroxy ketone derivative, is characterized by its unique molecular structure featuring a para-methylphenyl group and two hydroxyl groups attached to a central carbonyl carbon. Its versatility and functional groups make it a valuable intermediate in various industrial applications.

In recent years, the demand for 2,2-dihydroxy-1-(4-methylphenyl)ethan-1-one has surged due to its role in the synthesis of UV absorbers and photostabilizers, which are critical components in sunscreens and skincare products. With growing consumer awareness about skin protection and the harmful effects of UV radiation, this compound has become a focal point for researchers and manufacturers alike. Its ability to absorb ultraviolet light while maintaining stability under sunlight exposure makes it an ideal candidate for cosmetic formulations.

From a chemical perspective, the CAS 16208-14-3 compound exhibits notable reactivity due to its hydroxyl and carbonyl functional groups. These groups enable it to participate in condensation reactions, esterifications, and other transformations, making it a versatile building block for fine chemicals. Researchers have explored its potential in creating antioxidants and flavoring agents, further expanding its utility beyond traditional applications.

The synthesis of 2,2-dihydroxy-1-(4-methylphenyl)ethan-1-one typically involves the oxidation of 4-methylacetophenone or related precursors under controlled conditions. Advances in green chemistry have led to the development of more sustainable production methods, reducing environmental impact. This aligns with the global push toward eco-friendly manufacturing and the reduction of hazardous byproducts, a topic highly relevant in today’s chemical industry discussions.

In the pharmaceutical sector, CAS 16208-14-3 has been investigated for its potential as a drug intermediate. Its structural motifs are found in several bioactive molecules, prompting studies into its role in medicinal chemistry. For instance, derivatives of this compound have shown promise in anti-inflammatory and antimicrobial applications, though further clinical research is needed to validate these findings.

Another area of interest is the compound’s stability and compatibility with other ingredients. Formulators often seek compatible additives that do not degrade under storage conditions, and 2,2-dihydroxy-1-(4-methylphenyl)ethan-1-one has demonstrated excellent shelf-life performance. This property is particularly valuable in personal care products, where ingredient integrity is paramount.

From an analytical standpoint, the characterization of 16208-14-3 involves techniques such as HPLC, NMR spectroscopy, and mass spectrometry. These methods ensure purity and confirm structural integrity, which are critical for industrial and research applications. Quality control protocols for this compound are stringent, reflecting its importance in high-value formulations.

As the demand for specialty chemicals grows, 2,2-dihydroxy-1-(4-methylphenyl)ethan-1-one is poised to remain a key player in multiple sectors. Its adaptability, combined with ongoing research into new applications, ensures its relevance in an evolving market. For those seeking reliable chemical intermediates or exploring innovative formulations, this compound offers a compelling combination of functionality and performance.

In summary, 2,2-dihydroxy-1-(4-methylphenyl)ethan-1-one (CAS 16208-14-3) is a multifaceted compound with broad applicability in cosmetics, pharmaceuticals, and chemical synthesis. Its unique properties and alignment with current trends in sustainable chemistry and skin protection make it a subject of ongoing interest and innovation.

• 1145-04-6(4-Biphenylglyoxal hydrate)
• 48160-61-8(Ethanone,1,1'-(1,4-phenylene)bis[2,2-dihydroxy-)
• 54149-77-8(Ethanone, 2,2-dimethoxy-1-(4-methylphenyl)-)
• 1094-85-5(Ethanone,1,1'-[1,1'-biphenyl]-4,4'-diylbis[2,2-dihydroxy-)
• 1075-06-5(PHENYLGLYOXAL MONOHYDRATE)
• 447-43-8(1-(4-Fluorophenyl)-2,2-dihydroxyethanone)
• 4079-54-3(2-Hydroxy-4'-methylacetophenone)
• 582-24-1(2-Hydroxyacetophenone)
• 118888-62-3(2,2-Dihydroxy-1-(m-tolyl)ethanone)
• 28631-86-9(Ethanone, 1-phenyl-,dihydroxy deriv. (9CI))