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• 2. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

3-Amino-5-hydroxy-4,4-dimethylpentanoic Acid (CAS 161064-82-0): A Comprehensive Guide

3-Amino-5-hydroxy-4,4-dimethylpentanoic acid (CAS 161064-82-0) is a specialized organic compound that has garnered significant attention in pharmaceutical and biochemical research. This branched-chain amino acid derivative exhibits unique structural features, making it valuable for various applications in drug development and metabolic studies. The compound's molecular formula is C7H15NO3, with a molecular weight of 161.20 g/mol. Its distinct 4,4-dimethylpentanoic acid backbone combined with amino and hydroxy functional groups contributes to its versatile chemical behavior.

In recent years, the demand for custom amino acid derivatives like 3-amino-5-hydroxy-4,4-dimethylpentanoic acid has surged, particularly in the field of peptide synthesis and small molecule drug discovery. Researchers are increasingly exploring its potential as a building block for novel therapeutics, especially in targeting metabolic disorders and neurological conditions. The compound's chiral centers and functional group diversity make it particularly interesting for structure-activity relationship studies in medicinal chemistry.

The synthesis of 3-amino-5-hydroxy-4,4-dimethylpentanoic acid typically involves multi-step organic transformations, often starting from readily available precursors. Modern synthetic approaches emphasize green chemistry principles, reflecting the growing industry focus on sustainable pharmaceutical manufacturing. Analytical characterization of this compound typically employs techniques such as HPLC, NMR spectroscopy, and mass spectrometry to ensure purity and confirm structural identity.

From a biochemical perspective, the 3-amino-5-hydroxy-4,4-dimethylpentanoic acid structure presents interesting possibilities for enzyme inhibition studies. The dimethyl substitution at the 4-position creates steric effects that can influence molecular recognition processes. This property has led to investigations of its potential as a metabolic pathway modulator, particularly in studies related to amino acid metabolism and biosynthetic pathways.

The pharmaceutical industry has shown particular interest in CAS 161064-82-0 for its potential in prodrug development. The presence of both amino and hydroxy groups allows for various derivatization strategies, enabling improved drug delivery characteristics. Recent patent literature reveals growing intellectual property activity surrounding 3-amino-5-hydroxy-4,4-dimethylpentanoic acid derivatives, particularly in applications related to CNS-targeted therapeutics and metabolic disease treatments.

In the context of current research trends, 3-amino-5-hydroxy-4,4-dimethylpentanoic acid aligns with several hot topics in medicinal chemistry. These include the search for new antibiotic scaffolds, development of neuroprotective agents, and exploration of metabotropic glutamate receptor modulators. The compound's structural features make it a candidate for addressing these research needs while offering opportunities for intellectual property generation in competitive pharmaceutical markets.

Quality control of 3-amino-5-hydroxy-4,4-dimethylpentanoic acid follows stringent pharmaceutical standards, with specifications typically including ≥98% purity by HPLC analysis. Storage recommendations generally suggest 2-8°C under inert atmosphere to maintain stability. These handling requirements reflect the compound's sensitivity to oxidation and moisture, common considerations for amino acid derivatives with multiple functional groups.

The market for specialty amino acids like CAS 161064-82-0 has grown steadily, driven by increasing R&D investments in targeted therapies and personalized medicine. Current pricing trends reflect the compound's status as a research-grade chemical, with costs varying based on purity levels and order quantities. Supply chain considerations have become particularly important in the post-pandemic era, emphasizing the need for reliable sourcing of such specialized building blocks.

From a regulatory standpoint, 3-amino-5-hydroxy-4,4-dimethylpentanoic acid is generally classified as a research chemical rather than a therapeutic agent itself. However, researchers working with this compound should consult current Good Laboratory Practice (GLP) guidelines and local regulations regarding chemical handling and waste disposal. Proper documentation of Material Safety Data Sheets (MSDS) remains essential for laboratory use.

Future prospects for 3-amino-5-hydroxy-4,4-dimethylpentanoic acid appear promising, particularly as drug discovery efforts increasingly focus on novel molecular scaffolds. The compound's unique combination of steric hindrance and functional group accessibility positions it as a valuable tool for addressing current challenges in medicinal chemistry and chemical biology. Ongoing research will likely uncover additional applications for this interesting amino acid derivative in both academic and industrial settings.

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