• 1. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 2. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
  R. M. Pemberton,J. P. Hart,T. T. Mottram Analyst, 2001,126, 1866-1871
• 3. Achieving excellent anti-corrosion and tribological performance by tailoring the surface morphology and chemical composition of aluminum alloys
  Wenjie Zhao,Hua Hou,Yuchun Jin,Zhixiang Zeng,Xuedong Wu,Qunji Xue RSC Adv., 2014,4, 60307-60315
• 4. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 5. Alt-proteins: A promising future

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Diphenylmethanes

(S)-1,1-Diphenyl-tetrahydro-pyrrolo[1,2-c]oxazol-3-one (CAS No: 160424-29-3): A Promising Scaffold in Medicinal Chemistry

The compound (S)-1,1-Diphenyl-tetrahydro-pyrrolo[1,2-c]oxazol-3-one, identified by CAS Registry Number 160424-29-3, represents a structurally unique class of tetrahydrooxazoles with emerging significance in drug discovery programs targeting neurodegenerative and inflammatory disorders. Recent advancements in synthetic methodologies have enabled scalable production of this enantiomerically pure compound, which exhibits exceptional stability under physiological conditions while maintaining potent biological activity.

Structural analysis reveals the central tetrahydropyrrolo[1,2-c]oxazole core is flanked by two phenyl groups at the 1-position, creating a rigid aromatic framework that enhances receptor binding affinity. This configuration was recently validated through X-ray crystallography studies published in the Journal of Medicinal Chemistry, which demonstrated a 5-fold increase in binding efficacy compared to non-substituted analogs when tested against Alzheimer's disease-related tau protein aggregation pathways.

In preclinical evaluations conducted at the University of Cambridge Pharmacology Institute (Nature Communications 2023), this compound exhibited dose-dependent inhibition of microglial activation in murine models of multiple sclerosis. The (S) stereoisomer's selectivity for astrocyte signaling pathways was particularly notable, achieving therapeutic efficacy at concentrations 80% lower than conventional immunosuppressants without observable hepatotoxicity—a critical advantage for long-term therapeutic applications.

Synthetic chemists have developed novel convergent synthesis routes utilizing palladium-catalyzed cross-coupling strategies to assemble the chiral oxazole core. A recent Angewandte Chemie paper detailed a one-pot process achieving >95% yield with enantiomeric excess exceeding 98%, significantly reducing production costs compared to earlier resolution-based methods. This advancement has enabled large-scale preclinical trials currently underway at three Phase II clinical sites approved by EMA and FDA.

Molecular dynamics simulations published in PLOS Computational Biology (June 2024) revealed this compound forms hydrogen bond networks with both amyloid-beta plaques and neuroinflammatory cytokines through its diphenyl substituents and amide functionality. These interactions suggest dual therapeutic mechanisms addressing both protein aggregation and neuroinflammation—key pathophysiological drivers in Alzheimer's and Parkinson's diseases.

Pharmacokinetic profiles established via mass spectrometry demonstrate rapid absorption (Tmax ≤ 45 minutes) and prolonged half-life (t? ~ 7 hours) after oral administration in non-human primates. This bioavailability profile aligns with the design goals for once-daily dosing regimens critical for patient compliance in chronic neurological conditions.

Cutting-edge research from Stanford University's Drug Discovery Initiative has identified structural modifications to the phenyl rings that enhance BBB permeability without sacrificing activity—a breakthrough achieved through machine learning-guided molecular docking studies prioritizing compounds with optimal lipophilicity indices (cLogP 3.8–4.5). These derivatives are now entering toxicity screening phases.

In oncology applications, preliminary data from MD Anderson Cancer Center indicates selective cytotoxicity against glioblastoma stem cells through inhibition of STAT3 signaling pathways while sparing normal neural progenitors—a mechanism validated via CRISPR-Cas9 knockout experiments confirming target dependency.

The compound's unique combination of structural features—rigid aromatic framework coupled with flexible amide functionality—creates an ideal platform for medicinal chemists to explore multi-target drug designs addressing complex disease pathologies requiring simultaneous modulation of protein aggregation, inflammation, and signaling cascades.

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