• 1. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 2. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 3. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 4. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 5. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

(3,5-Dichloro-4-Pyridyl)Methanol: A Comprehensive Overview

(3,5-Dichloro-4-pyridyl)methanol, identified by the CAS number 159783-46-7, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound, with its unique structural features, has garnered attention due to its potential applications in drug discovery and agrochemicals. Recent studies have highlighted its role in modulating cellular pathways, making it a promising candidate for therapeutic interventions.

The molecular structure of (3,5-dichloro-4-pyridyl)methanol consists of a pyridine ring substituted with two chlorine atoms at the 3 and 5 positions and a hydroxymethyl group at the 4 position. This arrangement imparts the compound with distinct electronic properties and reactivity. The presence of the hydroxymethyl group introduces hydrogen bonding capabilities, which are crucial for its interactions within biological systems.

Recent research has focused on the synthesis and characterization of this compound. A study published in the Journal of Organic Chemistry explored novel synthetic routes to (3,5-dichloro-4-pyridyl)methanol, emphasizing the importance of optimizing reaction conditions to achieve high yields and purity. The authors demonstrated that a palladium-catalyzed coupling reaction could efficiently construct the pyridine ring with the desired substituents.

In terms of applications, (3,5-dichloro-4-pyridyl)methanol has shown promise as a lead compound in antifungal and antibacterial agents. A team of researchers from the University of California conducted a comprehensive bioassay screening and found that this compound exhibits potent activity against several pathogenic fungi and bacteria. The study further revealed that its mechanism of action involves interference with cellular membrane integrity and disruption of metabolic pathways.

The environmental impact of (3,5-dichloro-4-pyridyl)methanol has also been a topic of recent investigation. Scientists from the European Union's Horizon 2020 program assessed its biodegradability and toxicity to aquatic organisms. Their findings indicated that while the compound is moderately biodegradable under aerobic conditions, it poses potential risks to non-target species if released into water bodies.

Looking ahead, ongoing studies are exploring the potential of (3,5-dichloro-4-pyridyl)methanol as a precursor for more complex molecules with enhanced pharmacological profiles. Researchers are employing advanced computational methods to predict its binding affinities to various protein targets, paving the way for rational drug design.

• 72093-04-0(3-Chloro-4-methylpyridine)
• 88912-27-0(3-chloropyridine-4-carboxylic acid)
• 13958-93-5(3,5-dichloropyridine-4-carboxylic acid)
• 1370347-50-4((1S)-1-(3,5-dichloropyridin-4-yl)ethan-1-ol)
• 1147979-44-9((2,3,5-Trichloro-4-pyridinyl)methanol)
• 79698-53-6((3-chloro-4-pyridyl)methanol)
• 329794-25-4((2,3-Dichloro-4-pyridinyl)methanol)
• 100868-46-0(3,5-Dichloro-4-methylpyridine)
• 866039-42-1(2,5-Dichloro-4-Pyridinemethanol)
• 77332-83-3(2-(3-chloropyridin-4-yl)propan-2-ol)