Cas no 159635-49-1 (tert-butyl 4-methylidenepiperidine-1-carboxylate)
tert-butyl 4-methylidenepiperidine-1-carboxylate Chemical and Physical Properties
Names and Identifiers
-
- N-Boc-4-Methylenepiperidine
- TERT-BUTYL 4-METHYLENEPIPERIDINE-1-CARBOXYLATE
- 1-N-BOC-4-METHYLENE-PIPERIDINE
- 4-METHYLENE-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- 4-METHYLENEPIPERIDINE, N-BOC PROTECTED
- 1-Boc-4-Methylene-piperidine
- Boc-4-methylenepiperidine
- 1-tert-Butoxycarbonyl-4-methylenepiperidine
- 1-Boc-4-methylenepiperidine
- 1-N-Boc-4-methylenepiperidine,
- 1-Piperidinecarboxylic acid, 4-methylene-, 1,1-dimethylethyl ester
- (BMPS)
- 3-Maleimidopropionic acid NHS
- tert-butyl 4-methylidenepiperidine-1-carboxylate
- 4-Methylenepiperidine-1-carboxylic Acid tert-Butyl Ester
- 1-Boc-4-Methylenepip
- 1-N-BOC-4-METHYLENE-PIPERIDINE 98+%
- 159635-49-1
- 4-Methylenepiperidine, N-BOC protected 97%
- 1,1-Dimethylethyl 4-methylenepiperidine-1-carboxylate
- t-butyl 4-methylenetetrahydropyridine-1(2H)-carboxylate
- tert-butyl 4-methylene-1-piperidinecarboxylate
- 4-methylene-piperdine-1-carboxylic acid tert-butylester
- N-(tert-butoxycarbonyl)-4-methylene piperidine
- AC-6301
- DTXSID90373553
- PB12247
- 4-methylene-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester
- FT-0630002
- t-butyl 4-methylenetetrahydro-pyridine-1(2H)-carboxylate
- MFCD01632522
- A3529
- t-butyl 4-methylenetetrahydropyridine-1(2H)- carboxylate
- 1,1-dimethylethyl 4-methylidenepiperidine-1-carboxylate
- 1-Boc-4-(methylene)piperidine
- 4-Methylene-1-tert-butoxycarbonylpiperidine
- EN300-90343
- 4-methylene piperidine-1-carboxylic acid tert-butyl ester
- AKOS005256797
- 1-Boc-4-methylene piperidine
- B4809
- PDTZMULNKGUIEJ-UHFFFAOYSA-N
- J-523509
- tert-butyl 4-methylenepiperidine-1-carboxylate;1-N-BOC-4-METHYLENE-PIPERIDINE
- 1-N-Boc-4-methylenepiperidine
- CS-W002803
- BCP14857
- SY003909
- tert-butyl 4-methylene-piperidine-1-carboxylate
- tert-butyl 4-methylene-1-piperidine carboxylate
- PS-6156
- AM803276
- SCHEMBL8243744
- BB 0268224
- SCHEMBL137297
- DB-012010
-
- MDL： MFCD01632522
- Inchi： 1S/C11H19NO2/c1-9-5-7-12(8-6-9)10(13)14-11(2,3)4/h1,5-8H2,2-4H3
- InChI Key： PDTZMULNKGUIEJ-UHFFFAOYSA-N
- SMILES： O(C(N1CCC(=C)CC1)=O)C(C)(C)C
Computed Properties
- Exact Mass: 197.14200
- Monoisotopic Mass: 197.142
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 14
- Rotatable Bond Count: 2
- Complexity: 230
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 29.5A^2
- XLogP3: 1.9
Experimental Properties
- Color/Form: Colorless to Yellow Liquid
- Density: 1
- Boiling Point: 80°C/1mmHg(lit.)
- Flash Point: 109.6℃
- Refractive Index: 1.4630 to 1.4670
- PSA: 29.54000
- LogP: 2.51140
tert-butyl 4-methylidenepiperidine-1-carboxylate Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Warning
- Hazard Statement： H315-H319
- Warning Statement： P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
-
Hazardous Material Identification：
- Storage Condition：2-8 °C
tert-butyl 4-methylidenepiperidine-1-carboxylate Customs Data
- HS CODE：2933399090
- Customs Data：
China Customs Code:
2933399090Overview:
2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
tert-butyl 4-methylidenepiperidine-1-carboxylate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 011531-5g |
1-N-Boc-4-Methylene-piperidine |
159635-49-1 | 96% | 5g |
￡26.00 | 2022-03-01 | |
| Fluorochem | 011531-25g |
1-N-Boc-4-Methylene-piperidine |
159635-49-1 | 96% | 25g |
￡61.00 | 2022-03-01 | |
| Fluorochem | 011531-100g |
1-N-Boc-4-Methylene-piperidine |
159635-49-1 | 96% | 100g |
￡145.00 | 2022-03-01 | |
| AstaTech | 56847-5/G |
1-N-BOC-4-METHYLENE-PIPERIDINE |
159635-49-1 | 98% | 5g |
$34 | 2023-09-17 | |
| AstaTech | 56847-50/G |
1-N-BOC-4-METHYLENE-PIPERIDINE |
159635-49-1 | 98% | 50g |
$101 | 2023-09-17 | |
| AstaTech | 56847-250/G |
1-N-BOC-4-METHYLENE-PIPERIDINE |
159635-49-1 | 98% | 250g |
$POA | 2023-09-17 | |
| TRC | B809533-100mg |
tert-Butyl 4-Methylenepiperidine-1-carboxylate |
159635-49-1 | 100mg |
$ 64.00 | 2023-04-18 | ||
| TRC | B809533-1g |
tert-Butyl 4-Methylenepiperidine-1-carboxylate |
159635-49-1 | 1g |
$ 60.00 | 2022-06-06 | ||
| TRC | B809533-5g |
tert-Butyl 4-Methylenepiperidine-1-carboxylate |
159635-49-1 | 5g |
$ 80.00 | 2022-06-06 | ||
| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 60R0984-5g |
4-Methylene-piperidine-1-carboxylic acid tert-butyl ester |
159635-49-1 | 98% | 5g |
212.01CNY | 2021-05-08 |
tert-butyl 4-methylidenepiperidine-1-carboxylate Suppliers
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tert-butyl 4-methylidenepiperidine-1-carboxylate Related Literature
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Mengmeng Zhang,Liming Yang,Chao Tian,Meng Zhou,Guanghui An,Guangming Li Org. Biomol. Chem. 2019 17 2258
-
Runfeng Lin,Zheng Zhang,Shengtian Cao,Wen Yang,Yinglin Zuo,Xinye Yang,Jiancun Zhang,Juan Xu,Jing Li,Xiaojun Wang RSC Med. Chem. 2021 12 1222
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Guido Verniest,Karel Piron,Eva Van Hende,Jan Willem Thuring,Gregor Macdonald,Frederik Deroose,Norbert De Kimpe Org. Biomol. Chem. 2010 8 2509
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Wen-Dao Chu,Chun-Mei Wang,Shu Li,Zhi-Hong Dong,Teng Long,Jia-Xi Jiang,Bo Chen,Cheng-Yu He,Quan-Zhong Liu Org. Chem. Front. 2022 9 6973
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Jifeng Qi,Haibin Tang,Changwei Chen,Sunliang Cui,Gang Xu Org. Chem. Front. 2019 6 2760
Additional information on tert-butyl 4-methylidenepiperidine-1-carboxylate
Comprehensive Overview of tert-butyl 4-methylidenepiperidine-1-carboxylate (CAS No. 159635-49-1): Properties, Applications, and Industry Insights
tert-butyl 4-methylidenepiperidine-1-carboxylate (CAS No. 159635-49-1) is a specialized organic compound widely utilized in pharmaceutical intermediates and fine chemical synthesis. Its molecular structure features a piperidine core modified with a methylidene group and protected by a tert-butyl carboxylate moiety, making it a versatile building block for drug discovery and material science. The compound’s unique reactivity profile has garnered attention in recent years, particularly in the development of bioactive molecules and N-heterocyclic compounds.
In the context of current research trends, tert-butyl 4-methylidenepiperidine-1-carboxylate aligns with growing interest in sustainable synthesis and green chemistry. Researchers frequently explore its potential in catalytic transformations, such as cross-coupling reactions or asymmetric hydrogenation, to minimize waste generation. A 2023 study highlighted its role in streamlining the production of chiral amines, a class of compounds critical for agrochemicals and APIs (Active Pharmaceutical Ingredients).
The compound’s stability under ambient conditions and compatibility with common solvents (e.g., THF, dichloromethane) make it a practical choice for industrial-scale applications. Analytical techniques like HPLC and NMR spectroscopy are typically employed to verify its purity, which often exceeds 98% in commercial batches. Notably, its Boc-protected group allows selective deprotection under mild acidic conditions, a feature highly valued in multistep syntheses.
From an SEO perspective, users frequently search for "tert-butyl 4-methylidenepiperidine-1-carboxylate solubility" or "CAS 159635-49-1 suppliers," reflecting practical concerns about procurement and handling. Emerging queries also include "piperidine derivatives in drug design" and "Boc-protecting group alternatives," indicating broader interest in its chemical functionality. Addressing these topics, recent innovations have explored enzyme-mediated modifications of this compound to enhance stereoselectivity.
Environmental and regulatory considerations further shape discussions around 159635-49-1. While not classified as hazardous under major chemical inventories (e.g., REACH, DSL), proper storage in inert atmospheres is recommended to prevent degradation. Industry best practices emphasize lifecycle assessments to evaluate its ecological footprint, particularly in pharmaceutical waste management.
In conclusion, tert-butyl 4-methylidenepiperidine-1-carboxylate exemplifies the intersection of synthetic utility and modern chemical innovation. Its applications span from small-molecule therapeutics to advanced material precursors, with ongoing research continually expanding its potential. As demand for high-value intermediates grows, this compound remains a focal point for both academic and industrial R&D efforts.
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