Cas no 159383-94-5 (2-Debenzoyl-7,10-bisO-(triethylsilyl)-10-deacetyl-13-O-trimethylsilyl Baccatin III)

2-Debenzoyl-7,10-bisO-(triethylsilyl)-10-deacetyl-13-O-trimethylsilyl Baccatin III is a key intermediate in the semisynthesis of taxane derivatives, particularly paclitaxel and docetaxel. Its selectively protected hydroxyl groups enhance reactivity and yield in subsequent acylation and coupling reactions. The triethylsilyl and trimethylsilyl ether groups provide steric protection, improving stability during synthetic processes. This compound is valued for its high purity and consistent performance in complex organic transformations, facilitating efficient scale-up in pharmaceutical production. Its structural modifications allow precise control over functionalization, making it a versatile building block for advanced taxane-based therapeutics. Suitable for research and industrial applications, it meets stringent quality standards for synthetic intermediates.
2-Debenzoyl-7,10-bisO-(triethylsilyl)-10-deacetyl-13-O-trimethylsilyl Baccatin III structure
159383-94-5 structure
Product Name:2-Debenzoyl-7,10-bisO-(triethylsilyl)-10-deacetyl-13-O-trimethylsilyl Baccatin III
CAS No:159383-94-5
MF:C37H68O9Si3
MW:741.186935424805
CID:109197
Update Time:2025-06-09

2-Debenzoyl-7,10-bisO-(triethylsilyl)-10-deacetyl-13-O-trimethylsilyl Baccatin III Chemical and Physical Properties

Names and Identifiers

    • 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one,12b-(acetyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-11,12-dihydroxy-4a,8,13,13-tetramethyl-4,6-bis[(triethylsilyl)oxy]-9-[(trimethylsilyl)oxy]-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-
    • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-11,12-dihydroxy-4a,8,13,13-tet
    • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-11,12-dihydroxy-4a,8,13,13-tetramethyl-4,6-bis[(triethylsilyl)oxy]-9-[(trimethylsilyl)oxy]-7,11-methan
    • 2-Debenzoyl-7,10-bis[O-(triethylsilyl)]-10-deacetyl-13-O-trimethylsilyl Baccatin III
    • 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one,12b-(acetyloxy)-1,2a,3,4,4a,6,9,10,11,12,1...
    • 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one,12b-(acetyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-11,12-dihydr
    • 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one,12b-(acetyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-11,12-dihydroxy-4a,8,13,13-tetramethyl-4,6-bis[(triethylsilyl)oxy]-9-[(trimethylsilyl)o
    • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-11,12-dihydroxy-4a,8,13,13-tetramethyl-4,6-bis[(triethylsilyl)oxy]-9-[(trimethylsilyl)oxy]-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one
    • 13-O-trimethylsilyl-7,10-bis-O-triethylsilyl-2-debenzoyl-10-deacetyl baccatin (III)
    • 2-Debenzoyl-7,10-bisO-(triethylsilyl)-10-deacetyl-13-O-trimethylsilyl Baccatin III
    • Inchi： 1S/C37H68O9Si3/c1-15-48(16-2,17-3)45-27-21-28-36(23-42-28,43-25(8)38)31-33(40)37(41)22-26(44-47(12,13)14)24(7)29(34(37,9)10)30(32(39)35(27,31)11)46-49(18-4,19-5)20-6/h26-28,30-31,33,40-41H,15-23H2,1-14H3/t26-,27-,28+,30+,31-,33-,35+,36-,37+/m0/s1
    • InChI Key： OPJUXNZWUHWYAM-YFTSZZTPSA-N
    • SMILES： [Si](CC)(CC)(CC)O[C@H]1C[C@@H]2[C@@](CO2)([C@H]2[C@@H]([C@@]3(C[C@@H](C(C)=C([C@H](C([C@@]21C)=O)O[Si](CC)(CC)CC)C3(C)C)O[Si](C)(C)C)O)O)OC(C)=O

Computed Properties

  • Exact Mass: 740.41700

Experimental Properties

  • PSA: 120.75000
  • LogP: 7.13530

2-Debenzoyl-7,10-bisO-(triethylsilyl)-10-deacetyl-13-O-trimethylsilyl Baccatin III Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
D204100-1mg
2-Debenzoyl-7,10-bis[O-(triethylsilyl)]-10-deacetyl-13-O-trimethylsilyl Baccatin III
 159383-94-5
1mg
 $ 201.00 2023-09-08
TRC
D204100-2mg
2-Debenzoyl-7,10-bis[O-(triethylsilyl)]-10-deacetyl-13-O-trimethylsilyl Baccatin III
 159383-94-5
2mg
 $ 385.00 2023-09-08
TRC
D204100-5mg
2-Debenzoyl-7,10-bis[O-(triethylsilyl)]-10-deacetyl-13-O-trimethylsilyl Baccatin III
 159383-94-5
5mg
 $ 873.00 2023-09-08
TRC
D204100-10mg
2-Debenzoyl-7,10-bis[O-(triethylsilyl)]-10-deacetyl-13-O-trimethylsilyl Baccatin III
 159383-94-5
10mg
 $1608.00 2023-05-18

2-Debenzoyl-7,10-bisO-(triethylsilyl)-10-deacetyl-13-O-trimethylsilyl Baccatin III Production Method

2-Debenzoyl-7,10-bisO-(triethylsilyl)-10-deacetyl-13-O-trimethylsilyl Baccatin III Related Literature

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159383-94-5 (2-Debenzoyl-7,10-bisO-(triethylsilyl)-10-deacetyl-13-O-trimethylsilyl Baccatin III) Related Products

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