• 1. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 2. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 3. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 4. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
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• 5. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazoles

Comprehensive Overview of 2-(1,3-thiazol-4-yl)acetaldehyde (CAS No. 1592911-14-2): Properties, Applications, and Industry Insights

2-(1,3-thiazol-4-yl)acetaldehyde (CAS No. 1592911-14-2) is a specialized organic compound featuring a thiazole ring linked to an acetaldehyde functional group. This structure imparts unique reactivity, making it valuable in pharmaceutical, agrochemical, and material science research. With the growing demand for heterocyclic building blocks in drug discovery, this compound has garnered attention for its potential in synthesizing bioactive molecules targeting kinase inhibitors and antimicrobial agents.

The compound’s thiazole moiety is a hotspot in modern medicinal chemistry due to its prevalence in FDA-approved drugs like tiazofurin and sulfathiazole. Researchers are exploring 2-(1,3-thiazol-4-yl)acetaldehyde as a precursor for covalent inhibitors, a trending topic in targeted cancer therapies. Its aldehyde group offers versatile derivatization pathways, enabling conjugation with amines or hydrazines for bioconjugation applications—a technique widely used in antibody-drug conjugates (ADCs) development.

In agrochemicals, this compound’s derivatives show promise as plant growth regulators or pesticide intermediates. A 2023 study highlighted its role in synthesizing thiazole-based fungicides, addressing global concerns over crop resistance. The thiazole-acetaldehyde hybrid structure also aligns with green chemistry trends, as it can be functionalized via catalyst-free reactions, reducing environmental impact.

From a technical perspective, CAS No. 1592911-14-2 exhibits moderate stability under inert conditions but requires storage at ≤?20°C to prevent polymerization. Analytical methods like HPLC-MS and NMR are critical for purity verification, especially given its use in high-throughput screening libraries. Suppliers often provide ≥95% purity grades, with custom synthesis options for scaled-up production—a service increasingly sought after by contract research organizations (CROs).

The compound’s structure-activity relationship (SAR) is a focal point in AI-driven drug design. Machine learning models trained on thiazole-containing datasets predict its utility in neurological targets, such as GABA receptor modulators. This intersects with rising searches for neuroprotective compounds and blood-brain barrier penetrants, positioning 2-(1,3-thiazol-4-yl)acetaldehyde as a molecule of interest in CNS drug development.

Regulatory-wise, the compound falls under general laboratory chemicals, but compliance with REACH and GHS labeling standards is essential. Its non-hazardous profile at standard quantities facilitates global shipping, though users should consult SDS documentation for handling specifics. As patent landscapes evolve, several WO2023 applications cite derivatives of this compound for immuno-oncology uses, reflecting its commercial potential.

In material science, the conjugated π-system of the thiazole ring enables applications in organic semiconductors and OLED precursors. Recent breakthroughs in flexible electronics have spurred demand for such small-molecule dopants, with researchers optimizing its electroluminescent efficiency via structural tweaks.

For procurement, keywords like buy 2-(1,3-thiazol-4-yl)acetaldehyde, CAS 1592911-14-2 supplier, and thiazole aldehyde price rank highly in B2B searches. Major platforms like ChemSrc and MolPort list it under scaffold compounds, with prices varying by purity (typically $200–$500/g for lab-scale quantities). Bulk inquiries often reference GMP synthesis or isotope-labeled versions for tracer studies.

Future directions include exploring its click chemistry compatibility for proteolysis-targeting chimeras (PROTACs)—an area with 300% YoY publication growth. As sustainable synthesis gains traction, microwave-assisted routes for this compound are under investigation, potentially reducing reaction times from hours to minutes while improving atom economy.

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