• 1. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 2. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
  JaideepRay,PatrickBlonigan,EricT.Phipps,KathrynMaupin
• 3. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 4. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 5. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170

Comprehensive Overview of (2R)-4-methylpentan-2-amine (CAS No. 15761-50-9)

(2R)-4-methylpentan-2-amine, with the CAS number 15761-50-9, is a chiral amine compound that has garnered significant attention in recent years due to its potential applications in various fields, including pharmaceuticals, chemical synthesis, and materials science. This compound is characterized by its unique stereochemistry and chemical properties, making it a valuable intermediate and building block in the development of novel compounds and materials.

The structure of (2R)-4-methylpentan-2-amine consists of a five-carbon chain with a methyl group at the fourth position and an amine group at the second position. The (R) configuration at the chiral center imparts specific stereoselective properties to the molecule, which are crucial for its applications in asymmetric synthesis and drug development. The chiral nature of this compound allows for the selective synthesis of enantiomerically pure products, which is essential in pharmaceuticals where the biological activity often depends on the specific enantiomer.

Recent research has highlighted the importance of (2R)-4-methylpentan-2-amine in the synthesis of bioactive molecules. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that this compound can serve as a key intermediate in the synthesis of novel antiviral agents. The researchers utilized (2R)-4-methylpentan-2-amine to construct a series of derivatives that exhibited potent antiviral activity against several RNA viruses, including influenza and coronaviruses. This finding underscores the potential of (2R)-4-methylpentan-2-amine as a versatile platform for developing new therapeutic agents.

In addition to its pharmaceutical applications, (2R)-4-methylpentan-2-amine has also been explored for its use in catalysis. A study published in Catalysis Science & Technology reported that this compound can act as an efficient ligand in palladium-catalyzed cross-coupling reactions. The researchers found that (2R)-4-methylpentan-2-amine-based ligands significantly enhanced the catalytic efficiency and selectivity of these reactions, leading to higher yields and improved product purity. This application highlights the compound's potential in industrial-scale chemical synthesis.

The physical and chemical properties of (2R)-4-methylpentan-2-amine have been extensively studied. It is a colorless liquid with a characteristic amine odor. The compound has a boiling point of approximately 100°C at atmospheric pressure and is soluble in common organic solvents such as ethanol, methanol, and acetone. Its solubility in water is limited but can be enhanced by adjusting the pH or using co-solvents. These properties make it suitable for use in various chemical processes and reactions.

Safety considerations are an important aspect when handling (2R)-4-methylpentan-2-amine. While it is not classified as a hazardous material under most regulations, proper handling and storage practices should be followed to ensure safety. It is recommended to store the compound in tightly sealed containers away from heat sources and incompatible materials. Personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn when handling this compound to minimize exposure risks.

The environmental impact of (2R)-4-methylpentan-2-amine has also been evaluated. Studies have shown that it has low toxicity to aquatic organisms and does not bioaccumulate significantly in the environment. However, it is important to follow best practices for waste disposal to minimize any potential environmental impact.

In conclusion, (2R)-4-methylpentan-2-amine (CAS No. 15761-50-9) is a versatile chiral amine with significant potential applications in pharmaceuticals, chemical synthesis, and materials science. Its unique stereochemistry and chemical properties make it an attractive candidate for developing novel compounds and materials. Ongoing research continues to uncover new uses for this compound, further solidifying its importance in various scientific disciplines.

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