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• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Pyrimidine nucleotides 2',3'-cyclic pyrimidine nucleotides
• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Pyrimidine nucleotides Cyclic pyrimidine nucleotides 2',3'-cyclic pyrimidine nucleotides

Comprehensive Guide to Cytidine 2':3'-cyclic Monophosphate Monosodium Salt (CAS 15718-51-1): Properties, Applications, and Research Insights

Cytidine 2':3'-cyclic Monophosphate Monosodium Salt (CAS 15718-51-1), often abbreviated as 2':3'-cCMP Na, is a biologically significant nucleotide derivative that has garnered substantial attention in biochemical and pharmaceutical research. This cyclic phosphate ester of cytidine plays crucial roles in RNA metabolism, cellular signaling, and enzymatic processes. With the growing interest in nucleotide-based therapeutics and RNA research tools, this compound has become increasingly relevant in modern life sciences.

The molecular structure of Cytidine 2':3'-cyclic Monophosphate Monosodium Salt features a cyclic phosphate bridge between the 2' and 3' positions of the ribose sugar, distinguishing it from linear nucleotides. This unique configuration contributes to its stability and specific interactions with ribonucleases and other RNA-processing enzymes. Researchers particularly value its application in studying RNA degradation pathways and enzyme mechanisms, especially in the context of emerging RNA interference technologies and mRNA vaccine development.

From a biochemical perspective, 2':3'-cCMP Na salt serves as both a substrate and inhibitor for various enzymes involved in nucleic acid metabolism. Its monosodium form enhances water solubility, making it particularly suitable for in vitro studies and biochemical assays. Recent studies have explored its potential role in cellular signaling pathways, with some evidence suggesting involvement in stress responses and gene regulation mechanisms that are currently hot topics in epigenetics research.

The pharmaceutical industry has shown growing interest in cyclic nucleotide analogs like Cytidine 2':3'-cyclic Monophosphate for their potential therapeutic applications. While not directly used as drugs, these compounds serve as valuable research tools for developing nucleotide-based medications, particularly in areas such as antiviral drug discovery and cancer therapeutics. The COVID-19 pandemic has further highlighted the importance of understanding RNA biology, making compounds like this essential for virology research and vaccine development platforms.

In the laboratory setting, CAS 15718-51-1 is frequently employed as a standard or reference compound in HPLC analysis of nucleic acid derivatives and for calibrating instruments used in nucleotide quantification. Its well-defined spectral properties make it particularly useful for UV detection methods and mass spectrometry studies. Researchers working on RNA sequencing technologies or transcriptomics often utilize this compound to understand artifacts that may occur during RNA sample preparation.

The market for research-grade nucleotides including 2':3'-cyclic CMP sodium salt has expanded significantly with advancements in genomic technologies and personalized medicine. Suppliers typically offer this compound with high purity levels (>98%) suitable for sensitive biochemical applications. Proper storage conditions (typically -20°C in dry form) are essential to maintain stability, as with most nucleotide derivatives.

Recent innovations in RNA-based therapeutics have created new opportunities for compounds like Cytidine 2':3'-cyclic Monophosphate Monosodium Salt. Its applications extend to CRISPR technology research, where understanding RNA processing is crucial for improving gene-editing efficiency. Additionally, the compound's role in studying ribozyme activity contributes to fundamental research in origin of life studies and catalytic RNA - areas receiving increased attention in astrobiology and biochemistry.

Quality control of CAS 15718-51-1 material typically involves multiple analytical techniques including NMR spectroscopy, HPLC purity analysis, and mass spectrometry. These rigorous quality standards ensure reliability for research applications, particularly in enzymology studies where precise molecular interactions are being investigated. The monosodium salt form provides consistent solubility characteristics important for kinetic experiments and enzyme assays.

Future research directions for 2':3'-cyclic CMP derivatives may explore their potential in biomarker development and diagnostic applications, particularly in conditions involving altered RNA metabolism. The compound's relevance continues to grow alongside advancements in RNA nanotechnology and therapeutic oligonucleotides, positioning it as an important tool in both basic research and applied biotechnology sectors.

For researchers seeking high-purity nucleotide standards or enzyme substrates, Cytidine 2':3'-cyclic Monophosphate Monosodium Salt remains an essential biochemical reagent. Its applications span from fundamental studies of RNA structure and function to cutting-edge research in RNA therapeutics and vaccine development, making it a versatile compound in contemporary molecular biology and pharmaceutical sciences.

• 27552-98-3(Cytidine, cytidylyl-(3'®5')-, monoammonium salt (8CI,9CI))
• 2536-99-4(Cytidine, cytidylyl-(3'®5')-)
• 15466-01-0(2(1H)-Pyrimidinone,4-amino-1-(2,5-O-phosphinico-b-D-arabinofuranosyl)- (9CI))
• 73532-83-9(Fosteabine)
• 633-90-9(Cytidine, cyclic2',3'-(hydrogen phosphate))
• 3616-08-8(Cytidine, cyclic3',5'-(hydrogen phosphate))
• 14433-47-7(2(1H)-Pyrimidinone,4-amino-1-(3-O-phosphono-b-D-arabinofuranosyl)-)
• 74263-38-0(Cytidine, cyclic2',3'-(hydrogen phosphate), barium salt (2:1) (9CI))
• 65093-40-5(2(1H)-Pyrimidinone,4-amino-1-[5-O-[hydroxy(octadecyloxy)phosphinyl]-b-D-arabinofuranosyl]-, sodium salt (1:1))
• 54925-33-6(Cytidine 3',5'-Cyclic Monophosphate Monosodium Salt)