• 1. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 2. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 3. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 4. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 5. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropanes

Ibufenac Ethyl Ester (CAS No. 15649-02-2): A Comprehensive Overview

Ibufenac Ethyl Ester, also known by its CAS number 15649-02-2, is a compound that has garnered significant attention in the fields of pharmacology and organic chemistry. This ester derivative of ibufenac is widely studied for its potential applications in drug delivery systems and therapeutic interventions. The compound's structure, properties, and biological activities have been extensively researched, making it a subject of interest for both academic and industrial researchers.

The chemical structure of Ibufenac Ethyl Ester consists of an ibufenac moiety linked to an ethyl group via an ester bond. This structural arrangement imparts unique physicochemical properties to the compound, including enhanced solubility and bioavailability. Recent studies have highlighted the importance of such modifications in improving the pharmacokinetic profiles of drugs, making Ibufenac Ethyl Ester a promising candidate for various therapeutic applications.

One of the key areas of research involving Ibufenac Ethyl Ester is its role in anti-inflammatory and analgesic therapies. Preclinical studies have demonstrated that this compound exhibits potent anti-inflammatory activity, comparable to or even superior to some conventional non-steroidal anti-inflammatory drugs (NSAIDs). Its mechanism of action involves inhibition of cyclooxygenase (COX) enzymes, which are central to the inflammatory response. However, unlike traditional NSAIDs, Ibufenac Ethyl Ester has shown reduced gastrointestinal side effects in experimental models, making it a safer alternative for long-term use.

The synthesis of Ibufenac Ethyl Ester is typically achieved through esterification reactions involving ibufenac and ethanol. This process is optimized to ensure high yields and purity, which are critical for its application in pharmaceutical formulations. Researchers have also explored green chemistry approaches to synthesize this compound, reducing environmental impact while maintaining its quality.

Another significant aspect of Ibufenac Ethyl Ester research is its potential in targeted drug delivery systems. Due to its lipophilic nature, this compound can be incorporated into lipid-based nanoparticles or micelles, enhancing its ability to cross biological barriers such as the blood-brain barrier. Recent advancements in nanotechnology have further expanded its applicability, with studies focusing on its use in treating neuroinflammatory conditions.

In terms of toxicity and safety profiles, Ibufenac Ethyl Ester has been shown to exhibit low acute toxicity in animal models. Chronic toxicity studies are currently underway to assess its long-term safety for human use. Regulatory agencies have expressed interest in this compound due to its potential benefits over existing therapies, provided that ongoing safety evaluations confirm its suitability.

From a commercial perspective, Ibufenac Ethyl Ester is increasingly being considered for inclusion in over-the-counter (OTC) medications due to its efficacy and safety profile. Pharmaceutical companies are exploring formulations that leverage its unique properties to address unmet medical needs, particularly in chronic pain management and inflammatory diseases.

In conclusion, Ibufenac Ethyl Ester (CAS No. 15649-02-2) represents a promising advancement in medicinal chemistry. Its combination of favorable pharmacokinetics, potent anti-inflammatory activity, and improved safety profile positions it as a valuable addition to the arsenal of therapeutic agents. As research continues to uncover new applications and optimize its formulation, this compound is poised to make a significant impact on healthcare outcomes worldwide.

• 42436-07-7(cis-3-hexenyl phenylacetate)
• 102-19-2(Isopentyl 2-phenylacetate)
• 41283-72-1(Ibuprofen Ethyl Ester)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)