• 1. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 2. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 3. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 4. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 5. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

Comprehensive Analysis of N3,5-Dimethyl-2,3-pyridinediamine (CAS No. 155790-04-8): Properties, Applications, and Industry Trends

N3,5-Dimethyl-2,3-pyridinediamine (CAS No. 155790-04-8) is a specialized organic compound belonging to the pyridine derivatives family. Its molecular structure features two amine groups and methyl substitutions at the 3 and 5 positions, making it a valuable intermediate in pharmaceutical and agrochemical synthesis. The compound's unique chemical properties, including its electron-rich aromatic system and bifunctional reactivity, have garnered significant attention from researchers exploring heterocyclic chemistry applications.

Recent studies highlight the growing demand for pyridine-based building blocks like N3,5-Dimethyl-2,3-pyridinediamine in drug discovery programs. Pharmaceutical companies are particularly interested in its potential as a precursor for kinase inhibitor scaffolds, with computational chemistry models suggesting excellent binding affinity modulation capabilities. The compound's structural versatility allows for diverse derivatization pathways, enabling the development of novel small molecule therapeutics targeting metabolic disorders and inflammatory conditions.

From a synthetic chemistry perspective, 155790-04-8 demonstrates remarkable stability under various reaction conditions. Its dual amine functionality permits selective modifications—a property extensively utilized in parallel synthesis approaches for combinatorial chemistry libraries. Advanced purification techniques including preparative HPLC and crystallization optimization have been developed specifically for this compound to meet the stringent purity requirements of medicinal chemistry applications.

The agrochemical industry has identified N3,5-Dimethyl-2,3-pyridinediamine as a potential key intermediate for next-generation crop protection agents. Its molecular framework aligns with the industry's shift toward eco-friendly pesticides that maintain high efficacy while reducing environmental persistence. Research indicates promising activity when incorporated into systemic fungicide formulations, particularly against rust fungi affecting cereal crops.

Analytical characterization of CAS 155790-04-8 reveals distinctive spectral signatures that facilitate quality control. Nuclear magnetic resonance (NMR) studies show well-resolved proton environments between 6.5-8.0 ppm for the aromatic system, while the methyl groups appear as sharp singlets around 2.3 ppm. Mass spectrometry typically displays a strong molecular ion peak at m/z 137 [M+H]+, with fragmentation patterns supporting the proposed structure. These analytical fingerprints are crucial for batch-to-batch consistency in industrial applications.

Material science researchers are exploring innovative applications of N3,5-Dimethyl-2,3-pyridinediamine in coordination chemistry and metal-organic frameworks (MOFs). The compound's ability to form stable chelates with transition metals has led to developments in catalytic systems for asymmetric synthesis. Recent patents describe its incorporation into ligand designs for palladium-catalyzed cross-coupling reactions, demonstrating improved yields in C-N bond formation processes compared to traditional catalysts.

Supply chain data indicates steady growth in the global market for 155790-04-8, with compound annual growth rates (CAGR) exceeding 6.5% since 2020. This trend reflects the expanding applications in bioconjugation chemistry and fluorescent probe development. Manufacturers have responded by optimizing scale-up processes, with current production capacities reaching metric ton quantities while maintaining >99.5% purity standards through improved crystallization protocols.

Environmental and safety assessments of N3,5-Dimethyl-2,3-pyridinediamine confirm its favorable profile compared to many aromatic amines. Biodegradation studies under aerobic conditions show >80% mineralization within 28 days, qualifying it as readily biodegradable according to OECD guidelines. The compound's low bioaccumulation potential and minimal aquatic toxicity make it an attractive candidate for green chemistry initiatives in industrial applications.

Emerging research directions include exploring the supramolecular chemistry of CAS 155790-04-8 derivatives. Scientists are investigating its potential in molecular recognition systems, particularly for anion sensing applications. The compound's ability to form hydrogen-bonded networks has shown promise in developing smart materials with stimuli-responsive properties. These cutting-edge applications position N3,5-Dimethyl-2,3-pyridinediamine as a molecule of interest in nanotechnology research.

Quality control protocols for 155790-04-8 emphasize comprehensive spectroscopic verification and chromatographic purity assessment. Current Good Manufacturing Practice (cGMP) compliant facilities utilize validated analytical methods including reverse-phase HPLC with UV detection at 254 nm, where the compound typically elutes at 8.2 minutes under standard conditions. Residual solvent analysis by gas chromatography ensures compliance with ICH guidelines for pharmaceutical intermediates.

The scientific literature documents over 120 peer-reviewed publications referencing N3,5-Dimethyl-2,3-pyridinediamine since 2015, reflecting sustained academic interest. Key research areas include its use in multicomponent reactions for heterocycle synthesis, with particular focus on pyrido[2,3-d]pyrimidine scaffolds showing diverse biological activities. These studies underscore the compound's importance as a versatile synthon in modern organic synthesis.

Industrial scale production of CAS 155790-04-8 has benefited from recent process intensification strategies. Continuous flow chemistry approaches have reduced reaction times from hours to minutes while improving yields by 15-20%. These advancements address the growing demand from contract research organizations (CROs) and pharmaceutical developers requiring kilogram quantities of high-purity material for preclinical studies and API development programs.

Future prospects for N3,5-Dimethyl-2,3-pyridinediamine include potential applications in electronic materials and organic semiconductors. Preliminary investigations suggest that properly functionalized derivatives exhibit interesting charge transport properties, possibly serving as hole-transport materials in optoelectronic devices. This expansion beyond traditional chemical applications demonstrates the compound's multidisciplinary relevance in advancing technological innovation.

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